Wound Healing and Tissue Regeneration

Restoration of normal architecture and function following acute and chronic injury is a complex and self-limiting process involving recruitment of cells that clear dead tissue and facilitate wound healing, the differentiation of stem and progenitor cells, and in some organs such as the liver, activation and proliferation of mature cells. Impaired tissue regeneration that occurs in diseases such as diabetes may lead to the deposition of fibrotic tissue that impedes function.

PCOM researchers dissect the events leading to normal and abnormal wound healing and tissue regeneration in the liver, skin, heart, nervous system and eyes, with the purpose of developing treatments that promote the restoration of function.