Myo/Nog cells, also known as MyoD-negative/Noggin-positive cells, are a specific type
of stem cells that have been identified in skeletal muscle tissue. They are critical
for normal development of the human brain, eyes, heart and muscles. Furthermore, in
adults, Myo/Nog cells assist in wound healing and protect neurons. In other tissues—like
the lens of the eye—they contribute to a vision-impairing disease called posterior
capsule opacification (PCO), which may develop after cataract surgery.
These cells are characterized by their ability to differentiate into various cell
types, including muscle cells (myocytes) and bone cells (osteoblasts). The name "Myo/Nog"
comes from the combination of two factors expressed by these cells: MyoD, a muscle-specific
transcription factor, and Noggin, a secreted protein that plays a role in skeletal