Legacy of Healing: Honoring Generations Through Life and Loss January 30, 2024
Dr. Crenshaw Discusses Kidney Disease
President and CEO Jay S. Feldstein, DO '81, was joined recently by Daryl O. Crenshaw, MD, FACP, FASN, FASH, an adjunct faculty member at PCOM South Georgia, a practicing nephrologist, and an avid supporter of medical education. On the PCOM
Perspectives podcast, they discuss kidney concerns impacting Georgia's population
and how new technology can help.
Play PCOM Perspectives: Legacy of Healing
Growing up in rural Selma, Alabama, Crenshaw witnessed his family members struggle
with kidney disease. He specifically recalls the 1970s, when his uncle required dialysis
and received a transplant. Later on, he'd lose his grandmother to end-stage kidney
“I really did not like it,” he said. “My uncle actually died at the age of 39.”
Through the losses, Crenshaw was able to develop a special relationship and fondness
for the kidney throughout his time in medical school. He connected his own experiences
to what others were facing and moved towards a full-time career in nephrology.
“All throughout the South, I recognized that there was a tremendous burden of kidney
disease. I think this propelled me to pursue my aspirations of becoming a nephrologist,”
As Crenshaw trained in Atlanta, he saw the impact of the disease in his training.
In Georgia, the mortality rate of kidney disease is 30-40% higher than the national
He then decided to move somewhere that was endemic to kidney disease. Now living in
South Georgia, Crenshaw is working with new technology to help identify patients likely
to develop kidney failure.
“The two most common causes of kidney disease are diabetes and hypertension. When
you look at the combination of diabetes and hypertension, that comprises about 75%
of all people with the disease,” he said. “What has been revealed within the last
few years is the genetic component that’s affiliated with kidney disease.”
This genetic component, known as APOL-1, is identified in African Americans as a high-risk
allele variant in sub-Saharan Africa. This means that the variant is not expected
to directly cause a genetic condition on its own, but it can lead to an increased
risk or predisposition to develop kidney disease, if two high risk alleles are present.
Crenshaw notes that many of the ancestors who had this particular variant allele passed
it to their descendants.
“There's a large percentage of African Americans who carry this high-risk allele of
APOL-1,” he said. “Perhaps there's been a misattribution to hypertension when they
actually have this genetic component causing kidney disease.”
Thanks to the new research, doctors can now test for the gene with a swab of the cheek.
Because of this progress, Crenshaw believes there's a chance for treatments to come
down the pipeline that can target and mitigate the risk of kidney disease, particularly
in African Americans and those with African ancestry. An effort that will help many.
To hear the full conversation or listen to past episodes of PCOM Perspectives, visit
the College's Spotify page or search “Philadelphia College of Osteopathic Medicine” anywhere you get your podcasts.
Continuing What His Parents StartedLessons From Mom Combine With Medical School KnowledgeMed Student Selected as Research Scholar for Myeloma Health Equity Program
About Philadelphia College of Osteopathic Medicine
For the past 125 years, Philadelphia College of Osteopathic Medicine (PCOM) has trained
thousands of highly competent, caring physicians, health practitioners and behavioral
scientists who practice a “whole person” approach to care—treating people, not just
symptoms. PCOM, a private, not-for-profit accredited institution of higher education,
operates three campuses (PCOM, PCOM Georgia and PCOM South Georgia) and offers doctoral degrees in clinical psychology, educational psychology, osteopathic
medicine, pharmacy, physical therapy, and school psychology. The college also offers
graduate degrees in applied behavior analysis, applied positive psychology, biomedical
sciences, forensic medicine, medical laboratory science, mental health counseling,
physician assistant studies, and school psychology. PCOM students learn the importance
of health promotion, research, education and service to the community. Through its
community-based Healthcare Centers, PCOM provides care to medically underserved populations.
For more information, visit pcom.edu or call 215-871-6100.
Public Relations Manager
Office: 215-871-6325 | Cell:
Connect with PCOM