Ruth C. Borghaei, PhD | Biomedical Sciences | PCOM Faculty
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Professor of Biochemistry and Molecular Biology

Dr. Ruth Borghaei is a professor in the Department of Bio-Medical Sciences.


Dr. Borghaei  received her PhD in Microbiology and Immunology from Temple University School of Medicine in 1992 and her BS, (with highest distinction) in Microbiology from the University of Maine in 1987. She completed her postdoctoral studies at the Institute for Cancer Research of the Fox Chase Cancer Center in Philadelphia.


Dr. Borghaei is director of the Molecular Basis of Medicine course in the Masters in Biomedical Sciences program and also teaches molecular biology and genetics to those students and to first-year DO students.


Dr. Borghaei's research interest is in transcriptional regulation of gene expression, particularly in response to inflammation. In addition, her lab is also interested in studying mechanisms behind epigenetic changes that occur in chronic inflammation, and may be involved in increased risk of carcinogenesis.


Dr. Borghaei is a member of the PCOM chapter of Sigma Xi, the American Society for Biochemistry and Molecular Biology and the American Society of Genetics.


Previous grant funding and current application:

6/25/15 NIH-NIDCR, Principal Investigator
Regulation of DNA methylation and demethylation by inflammatory cytokines

7/1/10 to 6/30/11 CCDA, PCOM Principal Investigator
Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells.

9/1/04 to 8/31/10 NIH R15 DE16277 Principal Investigator
Transcriptional regulation of matrix metalloproteinase 3
[Research Supplement to Promote Diversity in Health-related Research, 2005-2006]

8/1/97 to 5/31/03 NIH R29 DE12096-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
[Supplement for Underrepresented Minorities, 2000-2001]

9/15/95 to 7/14/97 NIH RO3 DE11577-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts