Dr. Ruth Borghaei is a professor in the Department of Bio-Medical Sciences.
Dr. Borghaei received her PhD in Microbiology and Immunology from Temple University School of Medicine in 1992 and her BS, (with highest distinction) in Microbiology from the University of Maine in 1987. She completed her postdoctoral studies at the Institute for Cancer Research of the Fox Chase Cancer Center in Philadelphia.
Dr. Borghaei is director of the Molecular Basis of Medicine course in the Masters in Biomedical Sciences program and also teaches molecular biology and genetics to those students and to first-year DO students.
Dr. Borghaei's research interest is in transcriptional regulation of gene expression, particularly in response to inflammation. In addition, her lab is also interested in studying mechanisms behind epigenetic changes that occur in chronic inflammation, and may be involved in increased risk of carcinogenesis.
Chambers, M, Kirkpatrick, G, Evans, M, Gorski, G, Foster, S and Borghaei, RC (2013) IL-4 inhibition of IL-1 induced Matrix Metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal Kinase (JNK) Exp. Cell Res. 319:1398. NIHMS ID 470770
Borghaei, R.C. and Chambers, M. (2009) Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines. Pathol. Lab. Med. Int. 1:7.
Borghaei, R.C., Gorski, G., Javadi, M. and Chambers, M. (2009) NF-ƙB and ZBP-89 regulate MMP-3 expression via a polymorphic site. Biochem. Biophys. Res. Comm. 382(2009):269. NIHMSID 171948
Stewart, DK, Javadi, M., Chambers, M, Gunsolly, C, Gorski, G and Borghaei, RC (2007) Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARγ activation in human gingival fibroblasts. BMC Molecular Biology 8:12 PMC1810308
Borghaei, R.C., Rawlings, P.L. Jr., Javadi, M. and Woloshin, J. (2004) NF-B binds to a polymorphic repressor element in the MMP-3 promoter. Biochem. Biophys. Res. Comm. 316:182-188. PMC1595538
Jenkins, K, Javadi, M., and Borghaei, R.C. (2004) Interleukin-4 suppresses interleukin-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts. J. Periodontol. 75:267-275. PMC1595536
Daghigh, F., Borghaei, R.C., Thornton, R.D. and Bee. J.H. (2001) Human gingival fibroblasts produce nitric oxide in response to pro-inflammatory cytokines. J. Periodontol. 73:392-400.
Thornton, R.D., Lane, P., Borghaei, R.C., Pease, E.A., Caro, J., and Mochan, E. (2000) Interleukin-1 induces hypoxia inducible factor-1 in human gingival and synovial fibroblasts. Biochem. J. 350:307-312.
Gorski, G.K., Paul, M., SooHoo, H., Borghaei, R.C., Mochan, E., Thornton, R. and Pease, E. (1999) Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display. Inflamm Res. 48:S122-123
Borghaei, R.C., Sullivan, C. and Mochan, E. (1999) Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3). J. Biol. Chem. 274:2126-2131. PMC1595537
Borghaei, R.C., Sinai, R.S., Mochan, E. and Pease, E.A. (1998) Mitogen-inducible nuclear orphan receptor (MINOR) is induced by interleukin 1 in human synovial and gingival fibroblasts. Biochem. Biophys. Res. Comm., 251:334-338.
Fowler, M.J. Jr., Neff, M.S., Borghaei, R.C., Pease, E.A., Mochan, E. and Thornton, R.D. (1998) Induction of bone morphogenetic protien-1 by interleukin 1 in human fibroblasts. Biochem. Biophys. Res. Comm., 248:450-453.
Borghaei, R.C., Rawlings P.L., Jr. and Mochan, E. (1998) Interleukin 4 suppression of interleukin 1 induced transcription of collagenase (MMP-1) and stromelysin (MMP-3) in human synovial fibroblasts. Arthritis and Rheum., 41:1398-1406. PMC1602062
Ni, X., Borghaei, H., Borghaei, R.C., Thornton, R.D., Pease, E. and Mochan, E. (1997) DGLA discoordinately supresses IL-1 induced metalloproteinase mRNA levels in human synovial fibroblasts. Inflamm. Res. 46: S124-126.
Borghaei, H, Borghaei, R.C., Ni, X., Pease, E., Thornton, R. and Mochan, E. (1997) Inhibition of IL-1 induced Collagenase expression by dihomo-Ɣ-linolenic acid (DGLA) may be mediated by inhibition of NFƙB binding. Inflamm Res. 46:S177-178.
Soprano, D.R., Chen, L.X., Wu, S., Donigan, A.M., Borghaei, R.C. and Soprano, K.J. (1996) Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition. Oncogene 12:577-584
Carter, R., Yumet, G., Pena, A. Soprano, D.R. and Soprano, K.J. (1994) Transcriptional regulation of c-jun expression during late G1/S in normal human cells is lost in human tumor cells. Oncogene 9:2675-2682.
Carter, R., Cosenza, S., Pena, A., Lipson, K. Soprano, D.R. and Soprano, K.J. (1991) A potential role for c-jun in cell cycle progression through late G1 and S. Oncogene 6:229-235.
Holthius, J., Owen, T.A., van Wijnen, A., Wright, K.L., Ramsey-Ewing, A., Kennedy, M.B., Carter, R., Cosenza, S.C., Soprano, K.J., Lian, J.B., Stein, J.L. and Stein, G.S. (1990) Tumor cells exhibit deregulation of the cell cycle controlled proliferation specific histone gene promoter factor hinf-D. Science 247:1454-1457.
Dr. Borghaei is a member of the PCOM chapter of Sigma Xi, the American Society for Biochemistry and Molecular Biology and the American Society of Genetics.
6/25/15 NIH-NIDCR, Principal Investigator
Regulation of DNA methylation and demethylation by inflammatory cytokines
7/1/10 to 6/30/11 CCDA, PCOM Principal Investigator
Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells.
9/1/04 to 8/31/10 NIH R15 DE16277 Principal Investigator
Transcriptional regulation of matrix metalloproteinase 3
[Research Supplement to Promote Diversity in Health-related Research, 2005-2006]
8/1/97 to 5/31/03 NIH R29 DE12096-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
[Supplement for Underrepresented Minorities, 2000-2001]
9/15/95 to 7/14/97 NIH RO3 DE11577-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts