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MARINA D’ANGELO, PHD
Department of Bio-Medical Sciences - PCOM
Professor of Anatomy


Dr. D’Angelo has served as course director for the cellular anatomy portion of SPOM in the DO curriculum since 2005 and participant in the histology course for the M.S. in Biomedical Sciences program since 2001. In addition, Dr. D’Angelo participates in the gross anatomy courses for the MS in Biomedical Sciences, the Physician Assistant Studies program and the PhD in Physical Therapy program from Widener University. Her responsibilities include organization and presentation of lectures in a team-taught program and assistance of the students in the laboratory portion of the courses.

Co-Founder and Chief Science Officer, ProteaPex Therapeutics, LLC

ProteaPex Therapeutics, LLC has developed an innovative disease modifying therapeutic technology to treat post-traumatic osteoarthritis (PTOA). This new class of therapeutic, Extracellular Matrix Protection Factor™ (ECPF) is a novel, safe and effective intra-joint injection that reduces the pain and damage caused by PTOA. According to the World Health Organization, over 10% of the world’s population aged 60 or older has been diagnosed with osteoarthritis (OA), with 80% of the population aged 65 and older exhibiting radiographic evidence of OA. Unfortunately, the current standard of care is directed at later stages of the disease with the only attainable goal being relief from pain and improvement of joint function. A critical research goal for our group is the development of disease modifying OA drugs (DMOADs) that would target the early stages of OA. The company is currently focused on developing therapeutics for the veterinary market and has a broad base of products for treatment of orthopedic, dental and wound healing in both the veterinary and human markets. The co-founders of ProteaPex Therapeutics have over 30 years combined experience in the fields of skeletal biology, osteoarthritis and peptide design. In April 2014, ProteaPex Therapeutics was issued a patent on the "Compositions and Methods for Inhibition of MMP13:MMP-Substrate Interactions” by the US Patent Office.

Matrix Metalloprotease Production in the Dentin/Resin Hybrid Layer:
Bacterial and enzymatic degradation of adhesive bonding agents at adhesive/tooth interfaces compromises the long-term inhibition of bacterial leakage and prevention of secondary caries around composite resin restorations. It can be expected that blocking enzymatic degradation at the interface coupled with the elimination of invading bacteria will prolong the life expectancy of resin restorations. However, conclusive clinical evidence for a relationship between gap formation following enzymatic degradation and bacterial involvement at resin/tooth interfaces does not exist. The overarching hypothesis of the project is that endogenous MMPs, released and activated by adhesive procedures, hydrolyse collagen fibrils at resin/dentin interfaces compromising bond durability. In order to test this hypothesis, we must first demonstrate that endogenous MMPs can be measured in the dentin from the cavity wall of a single tooth, and which MMPs are the major players to be inhibited clinically.

Education

PhD, Developmental Biology/Teratology Thomas Jefferson University, July 1992

BS, Biology Drexel University, 1986

Associate Scientist (2000-2001) Department of Anatomy and Cell Biology, Steven Popoff, PhD – Advisor – Temple University School of Medicine, Philadelphia, Pa.

Lecturer/Postdoctoral Fellow (1998-2000) Biochemistry Department, Phoebe Leboy, PhD – Advisor – University of Pennsylvania School of Dental Medicine, Philadelphia, Pa.

NRSA Postdoctoral Researcher (1994-1998) Anatomy and Histology Department, Maurizio Pacifici, PhD--Advisor-- University of Pennsylvania School of Dental Medicine, Philadelphia, Pa.

Assistant Research Scientist (1992-1994) Pathology Department, Leslie Gold, PhD --Advisor -- NYU Medical Center, NYC, NY.

Awards

National Catholic Education Association Distinguished Graduate Award 2014: recognition of alumni for their achievements in professional and civic life.

People’s Choice Award 2012, Wharton Business Plan Competition: Consultant/Advisor for ChondroPro team.

Visiting Scholar (10/11-9/12) Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA

University City Science Center QED Proof-of-Concept Program Top Ten Finalist 2010: “Metalloprotease peptide derivative therapeutics for osteoarthritis.”

East Coast Connective Tissue Society Young Investigator Award 1999: “MMP-13 expression during chondrocyte maturation.”

Orthopaedic Research Society New Investigator Recognition Award 1997: “Changes in TGFß activation and isoform profiles accompany endochondral ossification.”

Orthopaedic Research Society New Investigator Recognition Award Semi-Finalist 1996: “Endogenously produced articular chondrocyte factors inhibit growth plate chondrocyte maturation.”

Grants

Commonwealth Universal Research Enhancement (CURE) Program 1/2011-12/2014 “Effect of Liposuction Technique on the Viability and Differentiation of Adipose Derived Stem Cells”

CCDA Grant 7/2013-6/2014 “Development of an in vitro, whole tooth model to study effects of endogenous matrix metalloprotease activity on resin restorations.”

Schoenleber Pilot Grant 12/2013-11/2015 “Inactivation of Matrix Metalloproteinase-8 by Extracellular Matrix Protection Factor -2 in Dentin Cavity Walls

NIDDK 5/2005 to 4/2009 “MPS VI and I feline model”- collaborator

NIDDK 2/2002 to 1/2007 “MPS VII canine model” – collaborator

National MPS Society Grant 7/2005 to 6/2007 “Biomarkers and treatments for joint pathology in MPS VI” -collaborator

National MPS Society Grant 7/2003 to 6/2005 “Joint pathology in MPS VI “ – collaborator

 

Other

Volunteer and Leadership Activities

Start-Up Company: Co-Founder and Chief Science Officer, ProteaPex Therapeutics, Inc (March 2011-Present) Innovations in Animal Health; www.proteapextherapeutics.com

Patent: “Compositions and methods for inhibition of MMP:MMP-substrate interactions” USPTO #61/391,446 docket number: P224717.US.02 (issued April 29, 2014)

Course Director, SPOM: Cellular Anatomy 2008-Present

President, PCOM Chapter, Sigma Xi Research Society 2005-2006

Vice President, PCOM Chapter, Sigma Xi Research Society 2003-2005

Faculty Forum Co-Chair 2013-Present

Chair Research Committee 2008-2013

Chair- Adhoc Committee on Research Personnel 2005-2006

Development and Launch of D.O/PhD program 2005-Present

Faculty-at-large Representative to Executive Faculty 2006-2007

Chair of Anatomy Department Faculty Search Committee 2007-2010

Chair of Anatomy Department Technician Search Committee 2008-2009

Moderator Small Group PCOM Research Retreat 2009

Secretary, PCOM Faculty Senate 2003-2007

Organizer for the Sigma Xi Annual Research Forum 2003-Present

Organizer for the PCOM Annual Research Day 2011-2013

Anatomy Program Organizer “National Youth Leadership Forum” Summer 2007- Present

Anatomy Program Organizer “Take Your Daughters and Sons to Work Day” 2010-Present

Journal Reviewer
  • Journal of Biological Chemistry, 2007-Present
  • Journal of Cellular Physiology, 2007-Present
  • The Open Endocrinology Journal, 2008-Present
  • Cytokines, 2009-Present
  • Cell Transplantation, 2010-Present
Study Section

Department of Defense PRMRP 9/2011; 10/2011; 5/2012: 9/2012; 10/2012

 

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