Department of Bio-Medical Sciences - Philadelphia
Professor of Clinical Pharmacology

Frederick J. Goldstein, PhD, FCP


Office: 215-871-6859
Research Page

Dr. Goldstein is professor of clinical pharmacology, Department of Bio-Medical Sciences. He joined the PCOM faculty in 1993. Prior to that time he served on the staff of the University of the Sciences in Philadelphia (USP). At PCOM he serves as coordinator of pharmacology for the medical school. In this capacity he has an extensive level of teaching in the first and second years of this curriculum, covering many topics in neuropharmacology (e.g., antidepressants, antipsychotics, opioids, drugs of abuse {e.g., LSD}). Dr. Goldstein also lectures in the PCOM graduate program in Biomedical Sciences. In addition, he also gives presentations in clinical pharmacology at the University of Pennsylvania School of Dental Medicine.

Dr. Goldstein conducts clinical investigations to increase analgesia in non-cancer non-terminal patients who are on long-term opioid medication for their chronic pain. His goal is to add different medications (e.g., antidepressants) that will provide the same or an improved level of analgesia, thus allowing the patient to use lower doses of opioids which will reduce adverse reactions.

Within the Graduate Medical Education department, he serves as Director of the Clinical Master of Science Program and Director of Research. He oversees the annual awarding of grants from the PCOM MEDNet to osteopathic residents who wish to conduct clinical investigations.

He is a Fellow in Clinical Pharmacology (FCP) of the American College of Clinical Pharmacology.

Dr. Goldstein serves on the editorial boards of the following journals: Clinical Pharmacology, Opioid Management, and Physical Medicine and Rehabilitation.

He served as book review editor for the Journal of the American Osteopathic Association from 2007 to 2012.

Dr. Goldstein received his Ph.D. in Pharmacology from the Philadelphia College of Pharmacy and Science (now known as the University of the Sciences in Philadelphia).

  • Education

    PhD, Pharmacology, University of the Sciences in Philadelphia, 1968
    MSc, Pharmacology, University of the Sciences in Philadelphia, 1965
    BSc, University of the Sciences in Philadelphia, 1963

  • Research

    Research Keywords:

    Pain Management
    Opioid Analgesia
    Osteopathic Manipulative Treatment (OMT)

  • Awards

    Lindback Award for Distinguished Teaching from the USP in 1990.

  • Publications

    Selected Publications

    Peer-reviewed Journals

    Hoegerl C., Goldstein, F.J., Sartorius J. “Evaluation of a Stroke Alert Program in the Emergency Dept; A Pilot Study” JAOA 111 21-27(2011).

    Goldstein, F.J., Jeck, S., Nicholas, A., Berman, M.A. Lerario, M, "Preoperative Morphine with Postoperative Osteopathic Manipulative Treatment Reduces Patient Analgesic Use After Hysterectomy" JAOA 105 273-279 (2005).

    McPhilemy, J.J., Hudanich, R., Hoertz, M., Goldstein, F.J., and Salinsky, J.P., "Osteochondral Autograft Transfer for the Treatment of large Chondral Defects and Osteochondritis Dessicans of the Knee: A Functional Outcome Study" JAmer Osteo Acad of Orthopedics37 62-65 (2000).

    Selected Presentations

    “Pain Management for Chronic Pain Patients”, Compassion and Care National Organization, Philadelphia Meeting, 2014

    “Pain Treatment For Your Loved Ones” [Presentation for the lay public], Abington Presbyterain Church & Beth Sholom Synagogue, 2014

    “Clinical Research: Development of an Investigation” Resident Orientation, PCOM, 2014.

  • Memberships

    Dr. Goldstein's memberships include the Rho Chi Honor Society, Sigma Xi, American Society for Pharmacology and Experimental Therapeutics, American College of Clinical Pharmacology, American Pain Society, and International Association for the Study of Pain.

  • Grants

    "Pennsylvania Study of Chronic Obstructive Pulmonary Exacerbations (PA-SCOPE) Phase 2: Impact of Easy Access to Preventive Care for Impending Acute COPD Exacerbation" Funded by a Pennsylvania Department of Health research grant from the state's share of the national tobacco settlement; Temple University School of Medicine, designated as a Center of Excellence, served as the lead institution.

    "Effect of Pre-operative Morphine and Post-op OMT Upon Post-op Pain After Total Abdominal Hysterectomy or Myomectomy." Principal investigator: Goldstein, F.J. Co-Investigators: Berman, M.A., Jeck, S., and Nicholas, A. Funded by the American Osteopathic Association

    "Evaluation of the Effect of Selected Osteopathic Manipulative Techniques on Headache Pain: A Randomized Clinical Outcomes Study." Funded by both the American Osteopathic Association and National Headache Foundation