Frederick J. Goldstein, PhD, FCP | PCOM Faculty
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Professor of Clinical Pharmacology

Dr. Goldstein is Professor of Clinical Pharmacology in the Department of Bio-Medical Sciences at PCOM.

Dr. Goldstein's research interests have focused on use of drugs to reduce pain in postoperative patients (C-section; gall bladder removal) and medications combined with osteopathic manipulation in post-surgical hysterectomy patients. His other studies have included use of drugs to reduce cancer pain and for those with chronic pain. He currently conducts two investigations to increase analgesia in those with chronic neuropathic pain using THC or a THC-CBD combination.

In addition to his teaching and research at PCOM, he lectures in pharmacology at the University of Pennsylvania School of Dental Medicine. Dr. Goldstein also serves on the editorial board of, and reviews submissions for, the Journal of Opioid Management. He is an active member of the National Board of Osteopathic Medical Examiners where he writes and reviews questions for the COMLEX Level 1 test.


  • PhD, Pharmacology, University of the Sciences in Philadelphia
  • MSc, Pharmacology, University of the Sciences in Philadelphia
  • BSc, University of the Sciences in Philadelphia


Dr. Goldstein's clinical interests have focused on pharmacologic methods to reduce pain in post-operative, cancer and hospice patients. He currently conducts research studies using THC or a THC-CBD combination to improve analgesia in patients presenting with chronic neuropathic pain.

Research keywords:

  • Pain Management
  • Opioid Analgesia
  • Osteopathic Manipulative Treatment (OMT)


Lindback Award for Distinguished Teaching from the USP in 1990.


Dr. Goldstein's memberships include the Rho Chi Honor Society, Sigma Xi, American Society for Pharmacology and Experimental Therapeutics, American College of Clinical Pharmacology, American Pain Society, and International Association for the Study of Pain.


"Pennsylvania Study of Chronic Obstructive Pulmonary Exacerbations (PA-SCOPE) Phase 2: Impact of Easy Access to Preventive Care for Impending Acute COPD Exacerbation" Funded by a Pennsylvania Department of Health research grant from the state's share of the national tobacco settlement; Temple University School of Medicine, designated as a Center of Excellence, served as the lead institution.

"Effect of Pre-operative Morphine and Post-op OMT Upon Post-op Pain After Total Abdominal Hysterectomy or Myomectomy." Principal investigator: Goldstein, F.J. Co-Investigators: Berman, M.A., Jeck, S., and Nicholas, A. Funded by the American Osteopathic Association

"Evaluation of the Effect of Selected Osteopathic Manipulative Techniques on Headache Pain: A Randomized Clinical Outcomes Study." Funded by both the American Osteopathic Association and National Headache Foundation

Conferences and Presentations

  • 2020, "Administration of delta-9-tetra-hydrocannabinol (THC) to improve analgesia in patients with neuropathic pain." American College of Clinical Pharmacology National Meeting Baltimore.
  • 2020, "Clinical Pharmacology of Medical Marijuana." Continuing Medical Education PCOM Family Medicine Conference.
  • 2019, "Clinical Pharmacology of Medical MJ." Grand Rounds – Abington Medical Center, Abington PA.
  • 2016, Keynote Speaker: Pain Management. 4th International Conference, Physical Medicine & Rehabilitation. Philadelphia, PA.