Christopher Scott Little, PhD | PCOM Faculty
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Associate Professor of Microbiology and Immunology

Dr. Little is active in the Biomedical Sciences Graduate Program and has participated in the course for over 10 years and currently serves as the course director for the Infectious Processes course. He is active in the Neurosciences course and recently joined Dr. Appelt as co-director of this course in 2013-2014. Additionally, Dr. Little has served as faculty advisor for numerous students earning their Master of Science degree upon completion of the research focus of the Biomedical Sciences Program. He is also involved in the education of Medical students and lectures in the Cellular and Molecular Basis of Medicine course. Dr. Little’s lecture material includes the following topics; inflammation, apoptosis, autoimmunity, allergy, acute phase reactants.

Research Keywords

Infection/Infectious disease
Alzheimer’s disease
Chronic Disease


PhD, Molecular Pathobiology Program MCP-Hahnemann University
BS, Eberly College of Science at the Pennsylvania State University


Dr. Little's research interests include immunology and chronic infection associated with diseases of aging, specifically the role of the immune system in modulating disease severity. One research focus includes the identification of elements of the immune system critical in the prevention of dissemination of the respiratory pathogen, Chlamydia pneumoniae, to extra-respiratory sites. He has published articles pertaining to the forementioned topic as well as investigating the role of Chlamydia pneumoniae infection in the induction of Alzheimer-like pathology in a non-transgenic mouse model of experimentally induced AD-like pathology. The experimental induction of Alzheimer-like pathology in non-transgenic mice serves as a model to study early developments and inducing factors that may lead to symptomatic illness for the sporadic/late onset form of Alzheimer's disease.

Additionally, Dr. Little’s research interests include the study of severe/life-threatening food allergy, particularly life-threatening allergic reactions following consumption to peanuts. These studies involve identifying key immune cells responsible for immune-modulation of the allergic response to peanut and then reprogramming these cells to ameliorate this condition. Dr. Little is a member of The New York Academy of the Sciences, The Alzheimer’s Association, The Microscopy Society of America and Sigma Xi Scientific Research Society.