ARTURO BRAVO NUEVO, PHD
Department of Bio-Medical Sciences - Philadelphia
Associate Professor of Neuroscience


Arturo Bravo Nuevo, PhD

Contact

Email: arturobr@pcom.edu
Office: 215-871-6345

Dr. Bravo Nuevo is an associate professor in the Department of Bio-Medical Sciences. He lectures on subjects related to the central nervous system, the visual system, retinal degenerative diseases and muscle physiology.

Dr. Bravo Nuevo has lectured in several universities including Sydney University, Australian National University, Harvard University and Aarhus University. He has mentored several high school and college students from Drexel University and Bryn Mawr college through masters programs and research projects.

He has active scientific and academic collaborations with several international universities in Australia, Spain and Denmark.

Dr. Bravo Nuevo is listed as the inventor in several patents. He is a senior advisor for several biotechnology companies and founded his own pharmaceutical company in 2014.

  • Education

    • Post-Doctoral Training at Harvard Medical School (Boston, MA)
    • Ph.D. from Australian National University (Canberra, Australia)
    • B.A and M.Sc. from Universidad Autonoma of Madrid (Madrid, Spain)
  • Research

    Dr. Bravo Nuevo has been working on neuroprotection of the retinal neuronal cells, muscle physiology and diabetes.

    Most recently, he has worked in the role that Myo/Nog cells have to prevent blindness caused by retinal degenerations, and slowing the progression of plaque formation in Alzheimer's disease.

  • Awards

    Current
    • Principal Investigator. “Role of Myo/Nog cells in Neuroprotection.” Anonymous donation - $284,318
    Past
    • Co-Principal Investigator on a $250,000 grant from March of Dimes. “Regulation of the Development of Anterior Eye Structures and Extra-ocular Muscles by Epiblast-Derived Skeletal Muscle Stem Cells”
        • Subproject: Role of Myo/Nog cells in the Developing Retina
    • Principal Investigator on a $60,000 grant from Dynamis Therapeutics Inc. “Meglumine effects on glycemic control on Type 2 diabetes and associated
      complications”
    • Co-investigator on a $300,000 grant from the American Diabetes Association (705RA10) “RhoB as a therapeutic target for diabetic microvascular complications”.
    • Awarded an AU$ 80,000 merit scholarship by the Department of Anatomy and Histology of the University of Sydney for doctoral studies.
    • Awarded the Outstanding International Student Scholarship by the 2000 – 2004 Australian Government.
    • Granted Young Investigators Travel Award for the Xth International 2002 Symposium in Retinal Degeneration
  • Publications

    Publications
    • Bravo-Nuevo A, Williams N, Geller S, Stone J: Mitochondrial deletions in normal and degenerating rat retina, Adv Exp Med Biol 2003, 533:241-248
    • Bravo-Nuevo A, Walsh N, Stone J: Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse, Invest Ophthalmol Vis Sci 2004, 45:2005-2012
    • Walsh N, Bravo-Nuevo A, Geller S, Stone J: Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALB/cJ mouse strains to oxygen stress: evidence of an oxygen phenotype, Curr Eye Res 2004, 29:441-447
    • Bravo-Nuevo A, Williams NK, Valter K, Stone J: Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains, Mitochondrion 2007, 7:340-346
    • Bravo-Nuevo A, O'Donnell R, Rosendahl A, Chung JH, Benjamin LE, Odaka C: RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy, Int Immunol 2011, 23:593-600
    • Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE: RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice, Am J Pathol 2011, 178:245-252
    • Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE: RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis, Cancer research 73.1 (2013): 50-61
    • Gerhart J, Greenbaum M, Scheinfeld V, FitzGerald P, Crawford M, Bravo-Nuevo A et al. Myo/Nog Cells: Targets for Preventing the Accumulation of Skeletal Muscle-Like Cells in the Human Lens. PloS one (2014)
    • Bravo-Nuevo A. et al. Meglumine Exerts Protective Effects against Features of Metabolic Syndrome and Type II Diabetes. PloS one 9, e90031 (2014).
    • Bravo-Nuevo A. et al. Neuroprotective effect of Myo/Nog cells in the stressed retina. Experimental Eye Research, 2016, 146: 22–25
    • Mondal A., DuHadaway J., Sutanto-Ward E., Smith C., Bravo-Nuevo A., Muller A. IDO1 is an Integral Mediator of Inflammatory Neovascularization. EBioMedicine, 2016, 14: 74-82
    • Brandli A, et al. Bravo-Nuevo A. Role of Myo/Nog Cells in Neuroprotection: Evidence from the Light Damaged Retina. PLoS One, 2017, http://dx.doi.org/10.1371/journal.pone.0169744
    Presentations
    • Myo/Nog Cells and Neuroprotection. Arturo Bravo-Nuevo. University of Aarhus (Denmark), July 2015. Lecture by invitation.
    • Myo/Nog Cells and Neuroprotection. Arturo Bravo-Nuevo. UC Davis, June 2015. Lecture by invitation.
    • Myo/Nog Cells and Neuroprotection. Arturo Bravo-Nuevo. Genisphere, January 2014. Lecture by invitation.
    • Myo/Nog Cells Promote Photoreceptor Cell Survival in the Stressed Retina. Arturo Bravo-Nuevo, Alice Amelia Brandli, Jacquelyn Gerhart, Meghan Pitts, Jonathan Stone and Mindy George-Weinstein. The Association for Research in Vision and Ophthalmology (Seattle, WA) May 2013. Selected Poster
    • Neuroprotective effect of Myo/Nog cells in the stressed retina. University of Western Sydney (Sydney, Australia) October 2012. Lecture by invitation
    • Myo/Nog cells are essential for retinal developments and neuronal protection in the stressed retina. University of Sydney (Sydney, Australia) October 2012. Lecture by invitation
    • Loss of RhoB prevents type 1 diabetes and ameliorates diabetic complications. Lankenau Institute for Medical Research August 2010. Lecture by invitation
    • Expression of RhoB’s link to the onset of Type I diabetic and progression of the associated complications. Lankenau Institute for Medical Research. Arturo Bravo-Nuevo, Hikaru Sugimoto, Seema Iyer, Raghu Kalluri and Laura E. Benjamin. August 2010. Lecture by invitation
    • RhoB and Diabetic Complications. Arturo Bravo-Nuevo, Laura E.Benjamin. RhoB and Diabetic Complications. Guest speaker for the Emergency Medicine Department. BIDMC. March 2009. Lecture by invitation.
    • Relationship Between Mitochondrial DNA Damage And Photoreceptor Death In Developing and Adult Retina, Assessed In Normal And Degenerative Rat Strains. Arturo Bravo-Nuevo, Neal Williams, Krisztina Valter-Kocsi and Jonathan Stone. ICER 2004 conference (August 2004 Sydney, Australia).
    • Mitochondrial DNA deletions and Retinal Degenerations. Arturo Bravo-Nuevo, Neal Williams, Scott Geller and Jonathan Stone. Xth International Symposium on Retinal Degeneration (Oct 2002 Bürgenstock, Switzerland).
    • Mitochondrial DNA deletions and Retinal Degenerations. Arturo Bravo-Nuevo, Neal Williams, Scott Geller and Jonathan Stone. The Australasian Ophthalmic and Visual Science meeting (Dec 2002 Sydney, Australia).
    • Mitochondrial DNA deletions and Retinal Degenerations. Arturo Bravo-Nuevo, Neal Williams, Scott Geller and Jonathan Stone. II IBR conference (Dec 2002 Sydney, Australia).
    • Ambient light regulates the Rate of Photoreceptor degeneration in RCS rats during the critical period of retinal development. Arturo Bravo-Nuevo, Krisztina Valter-kocsi and Jonathan Stone. Ist IBR conference (Dec 2001 Sydney, Australia).
    • Ambient light regulates the Rate of Photoreceptor degeneration in RCS rats during the critical period of retinal development. Arturo Bravo-Nuevo, Krisztina Valter-kocsi and Jonathan Stone. The Australasian Ophthalmic and Visual Science meeting (Dec 2001 Sydney, Australia).
    • Time course of photoreceptor degeneration and bFGF regulation during light damage in the C57 black mouse. Arturo Bravo-Nuevo, Scott Geller, Krisztina Valter-kocsi and Jonathan Stone. The Australasian Ophthalmic and Visual Science meeting (Dec 2000 Sydney, Australia) ARTURO BRAVO NUEVO, Ph.D. PAGE 5
    • Time course of photoreceptor degeneration and bFGF regulation during light damage in the C57 black mouse. Arturo Bravo-Nuevo, Scott Geller, Krisztina Valter-kocsi and Jonathan Stone. IX International Symposium on Retinal Degeneration (Oct 2000 Durango, USA)
  • Memberships

    • American Diabetes Association
    • Association for Research in Vision and Ophthalmology
  • Grants

    Principal Investigator. “Role of Myo/Nog cells in Neuroprotection.”
    Anonymous donation
    $284,318