Annual Symposium Advances Dialogue on Alzheimer's and Other Dementias
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2nd Annual AlzPI and PCOM Symposium Advances Dialogue on Infection-Linked Brain Disorders


October 14, 2025
Neurological disease experts Kevin Zwezdaryk, PhD, and Brian Balin, PhD, talk in a lecture hall during the AlzPI x PCOM Symposium

Researchers, clinicians, patients and advocates from around the world gathered last week at Ohio University for the 2nd Annual AlzPI and PCOM Symposium, the one-day hybrid event aimed at sharing interdisciplinary research on the role of infections and the microbiome—in Alzheimer's disease, related dementias, and other neurological and psychiatric diseases.

The annual conference highlighted emerging evidence connecting infection and inflammation to neurodegeneration and called for stronger collaboration across researchers in neurology, psychiatry, immunology, microbiology and infectious disease.

More than 20 experts presented research exploring how microbial and immune factors contribute to disorders such as Alzheimer's disease, Parkinson's disease, PANDAS/PANS, Lyme disease, long COVID and multiple sclerosis. Among the speakers was Brian Balin, PhD, Director of the Center for Chronic Disorders of Aging at PCOM, who discussed his three decades of research on microbial involvement in Alzheimer's disease.

Nikki Schultek, Co-Founder and Executive Director of AlzPI and Founding Director of the PCOM Pathobiome Research Center smiles as she speaks during the event

Other speakers included patients and caregivers, including Nikki Schultek, Co-Founder and Executive Director of AlzPI and Founding Director of the PCOM Pathobiome Research Center, who emphasized patient-centered collaboration, alongside others sharing personal stories that underscored the human impact of infection-associated brain disorders.

“This year's meeting reaffirmed a growing consensus—that understanding infection-associated brain disorders requires not just advanced science, but empathy, collaboration and the courage to reimagine the framework of how brain health itself is evaluated and maintained,” shared Schultek when reflecting on the day’s successes.

The symposium closed with a unifying call to dismantle disciplinary silos and adopt a shared biological lens across neurological and psychiatric disease. Both Dr. Balin and Schultek are confident that meetings such as these will continue to foster connection and collaboration, ultimately creating more patient-accessible therapies.

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