Alex Wang (DO ’20) was born in San Jose, California, before moving to Hong Kong where
he grew up. After completing high school in Hong Kong, he moved to Atlanta and attended
Emory University where he graduated with a Bachelor of Science degree, majoring in
neuroscience and behavioral biology and minoring in economics. Prior to matriculating
into GA-PCOM, he held a research assistant position, worked at the Centers for Disease
Control and Prevention, and received a Master of Public Health in global epidemiology
from Rollins School of Public Health at Emory University. Upon completion of his Doctor
of Osteopathic Medicine degree, he intends to practice medicine and finally adopt
What did you study?
The lab I worked in was under the supervision of Dr. Huo Lu, PhD, Professor of Anatomy, Georgia Campus – Philadelphia College of Osteopathic Medicine
(GA-PCOM), where we were studying the effects of Direct Current Stimulation (DCS)
on rat Purkinje cells using an in vitro approach. Purkinje cells are neurons found in the cerebellum of the brain. They are
thought to not only be responsible for learning, but also the coordination of movement.
We hypothesized that by placing a Purkinje cell in an electric field, and alternating
the direction of the field, we would be able to change the way these neurons responded.
To do this we used a method called patch-clamping where we attached a recording electrode
to the membrane of the neurons and recorded how often an action potential was generated.
What prompted you to pursue research?
My first taste of research was during my international baccalaureate program in high
school, where I designed an experiment to determine whether the use of nasal strips
really did improve an athlete’s ability to perform. Needless to say I was hooked and
since then I have worked with various professors on basic science, clinical and epidemiological
research projects. Not only was I able to contribute (no matter how small) to our
ever expanding understanding of our world, but I was also able to apply my knowledge
in a real world setting where I had to critically think to solve problems.
What experience do you have with conducting research?
Prior to working in Dr. Lu’s lab, I worked in a neurosurgery lab at Emory University
School of Medicine where I assisted in determining the efficacy of neuroregeneration
by performing sub-retinal injections in mice. I also worked with the Grady Trauma
Project at Grady Memorial Hospital where I interviewed patients to determine the clinical
and physiological implications of trauma exposure on the development of Post-Traumatic
Stress Disorder. During my MPH, I performed a genome-wide association study for my
thesis project on how genetic variants associated with Toxoplasma gondii infection affected the risk of developing schizophrenia.
What were your responsibilities in the research project?
Along with two other osteopathic students (Tracy Phan (DO ’20) and Cameron Moore (DO
’20), I conducted experiments by collecting Purkinje cells from rats, patch-clamping
these neurons, and recording the action potential firing rates as we switched between
anodal and cathodal current stimulation. Using the data collected from these experiments
I wrote a data analysis code that allowed for the interpretation of our results. I
prepared and presented this data as a poster at GA-PCOM’s annual Research Day in May.
What is the broader impact of your research?
The hypoplasia or atrophy of Purkinje cells in the cerebellum has been implicated
in many conditions, most notably cerebellar ataxia. Cerebellar ataxia encompasses
a wide range of neurological disorders characterized by a lack of coordinated movements
that affect the quality of life for an individual. Recently, transcranial Direct Current
Stimulation (tDCS) has been shown to be a possible therapy of cerebellar ataxia in
humans. However, the exact mechanism of how this treatment improves the condition
remains a mystery. Using an in vitro approach and applying DCS to neurons found in the cerebellum, we want to understand
how electric fields alter the way neurons respond. By comprehending how the single
cell responds, we can start to recognize how tDCS affects groups of neurons, such
as those found in the cerebellum.
Established in 2005, PCOM Georgia is a private, not-for-profit, accredited institute of higher education dedicated
to the healthcare professions. The Suwanee, Georgia, campus is affiliated with Philadelphia
College of Osteopathic Medicine, a premier osteopathic medical school with a storied
history. PCOM Georgia offers doctoral degrees in osteopathic medicine, pharmacy, and
physical therapy and graduate degrees in biomedical sciences, medical laboratory science,
and physician assistant studies. Emphasizing "a whole person approach to care," PCOM
Georgia focuses on educational excellence, interprofessional education and service
to the wider community. The campus is also home to the Georgia Osteopathic Care Center,
an osteopathic manipulative medicine clinic, which is open to the public by appointment.
For more information, visit pcom.edu/georgia or call 678-225-7500.
For more information, contact: Barbara Myers Senior Public Relations Manager Email: BarbaraMy@pcom.edu Office: 678-225-7532 | Cell: