Dr. Huang has rich experiences in teaching at various levels in inter-cultural settings. Dr. Huang found his passion in teaching when he was a graduate assistant in China. Later during his PhD training years at Iowa State University, he enjoyed teaching Human Anatomy and Physiology Labs to non-majors for a few years. After moving to the University of Toronto, Canada, he was blessed with the opportunity for one-on-one teaching/tutoring. While on the faculty of Drexel University College of Medicine, he taught various subjects such as Neurosciences, Biochemistry and Cell Biology.
At PCOM School of Pharmacy, Dr. Huang has taught Anatomy, Biochemistry, Physiology and Pathophysiology I and II, and Integrated Therapeutics III and V. He also co-teaches with Dr. Bai the elective course on Biologics and Biopharmaceuticals.
Dr. Huang’s research interest lies in brain physiology and pathophysiology. Currently his main focus is on the mechanisms of synaptic plasticity, and especially on the regulation of the NMDA subtype of the glutamate receptors. "NMDA receptors", as they are called, play critical roles in learning and memory, and in the development of the brain. As NMDA receptors are also critically important in brain disorders, his studies have significant implications that extend to a broad range of pathological processes in the central nervous system, including brain and spinal cord injury, epilepsy, chronic pain, stroke, Alzheimer disease, and schizophrenia. In the Department of Pharmaceutical Sciences, Dr. Huang's research projects continue to address the issue of glutamate receptor regulation, and he prides himself on taking an integrated approach using a combination of biochemistry, cell biology, physiology and pharmacology.
Hu, J., Liu, G., Li, Y., Gao, W.J. and Huang, Y.Q., (2010) Dopamine D1 receptor-mediated
NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical
neuron. Molecular Brain 2010, 3:20.
Li, YC., Liu, G., Hu, J. Gao, W.J. and Huang, Y.Q., (2010) Dopamine D1 Receptor-mediated Enhancement of NMDA Receptor Trafficking Requires Rapid PKC-dependent Synaptic Insertion in the Prefrontal Neurons.Journal of Neurochemistry. 114: 62–73.
Li, Y., Xi, D., Roman, J., Huang, Y.Q. and Gao, W.J., (2009) Activation of GSK-3beta is Required for Hyperdopamine and D2 Receptor Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex. Journal of Neuroscience. 29:15551-63.
Kollins, K.M., Hu, J., Bridgman, P.C., Huang, Y-Q, and Gallo, G.. (2009) Myosin-II Negatively Regulates minor process extension and the temporal development of neuronal polarity. Developmental Neurobiology69, 279-98.
Nong, Y., Huang, Y.Q., and Salter, M.W. (2004) NMDA receptors are movin’ in. Current Opinion in Neurobiology. 14, 353-361.
Gingrich, J.R., Pelkey, K.A., Fam, S., Huang, Y.Q., Petralia, R.S., Wenthold, R.J., and Salter, M.W. (2004) Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc Natl Acad Sci USA. 101, 6237-6242.
Nong, Y.*, Huang, Y.Q.*, Ju, W.*, Kalia, L.V., Ahmadian,R., Wang, Y.T. and Salter, M.W. (2003) Glycine binding primes NMDA receptors internalization. Nature 422, 302-307. (*Co-first authors)
Huang, Y.Q., Lu, W., Ali, D.W., Pelkey, K.A., Pitcher, G.M., Lu, Y.M., Aoto, H., Roder, J.C., Sasaki, T., Salter, M.W., MacDonald, J.F. (2001) CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Neuron. 29(2): 485-96.
Reviewer, Journal of Neuroscience
Reviewer, Journal of Neurochemistry
Reviewer, Brain Research
Intramural Research Grant, Philadelphia College of Osteopathic Medicine, Center for Chronic Disorders of Aging (CCDA), Philadelphia, PA, 2011-2012.
Research Grant, Young Investigator Award, NARSAD, 2006-2009. (NARSAD, Now called “Brain and Behavior Research Foundation”, The World's Leading Foundation Dedicated to Mental Health Research)
Canadian Institutes of Health Research /Heart and Stroke Foundation of Canada, 2001-2003.
Ontario Neurotrauma Foundation, Ontario, Canada, 2000-2001
Young Investigator Award, Spinal Cord Research Foundation, Paralyzed Veterans of America, USA 1998-2000