Publications
Research Papers
(*Co-first author)
Kaffash E, Pangeni R*, Liang W, Poudel S, Zhao L, Ma J, Xu Q. Fenofibrate microemulsion
eyedrops for treating nitrogen mustard-induced corneal injury. Journal of Controlled Release. 2026.
Pangeni R, Poudel S, Herz SM, Berkbigler G, Duerfeldt AS, Damaj MI, Xu Q. New PPARα
agonist A190-loaded microemulsion for chemotherapy-induced peripheral neuropathy.
Molecular Pharmaceutics. 2025; 22(3):1641–1656.
Pangeni R, Poudel S, Momin MAM, Farkas D, Dalton C, Hall F, Kang DJ, Hylemon P, Longest
W, Hindle M, Xu Q. Inhalable tobramycin EEG powder formulation for treating Pseudomonas
aeruginosa-induced lung infection. International Journal of Pharmaceutics. 2024; 662: 124504.
Pangeni R, Hassan AAM, Farkas D, Sudarjat H, Longest W, Hindle M, Xu Q. New air-jet
dry powder insufflator for high-efficiency aerosol delivery to rats. Molecular Pharmaceutics. 2023; 20(4); 2207-2216.
Pangeni R, Laxman S, Jha SK, Choi JU, Kweon S, Kang SH, Chang KY, Choi YK, Byun Y,
Park JW. Improvement of oral absorption and anticancer efficacy of oxaliplatin-loaded
solid formulation: Pharmacokinetic properties in rats and nonhuman primates and the
effects of oral metronomic dosing on colorectal cancer. International Journal of Nanomedicine. 2020 9;15:7719-7743.
Lee BC, Pangeni R*, Na J, Koo K, Park JW. Preparation and in vivo evaluation of a
highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment
of onychomycosis. Drug Delivery. 2019; 26:1167–1177.
Pangeni R, Jha SK, Maharjan R, Choi JU, Chang KY, Choi YK, Byun Y, Park JW. Intestinal
transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating
an ion-pairing complex of pemetrexed with deoxycholic acid derivatives. International Journal of Nanomedicine. 2019; 14:6339–6356.
Jee JP*, Pangeni R*, Jha SK, Byun Y, Park JW. Preparation and in vivo evaluation of
a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin,
and oxygen carriers for enhanced diabetic wound-healing therapy. International Journal of Nanomedicine. 2019; 15:5449–5475.
Pangeni R, Panthi VK, Yoon IS, Park JW. Preparation, characterization, and in vivo
evaluation of an oral multiple nanoemulsive system for co-delivery of pemetrexed and
quercetin. Pharmaceutics. 2018; 10(3):1–22.
Pangeni R, Choi JU, Panthi VK, Byun Y, Park JW. Enhanced oral absorption of pemetrexed
by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion
formulations: preparation, characterization, and in vivo oral bioavailability and
anticancer effect. International Journal of Nanomedicine. 2018; 13:3329–3351.
Pangeni R, Kang S-W, Oak M, Park EY, Park JW. Oral delivery of quercetin in oil-in-water
nanoemulsion: In vitro characterization and in vivo anti-obesity efficacy in mice.
Journal of Functional Foods. 2017; 38:571–581.
Pangeni R, Choi SW, Jeon OC, Byun Y, Park JW. Multiple nanoemulsion system for an
oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in
vivo evaluation. International Journal of Nanomedicine. 2016; 11:6379–6399.
Pangeni R, Sharma S, Mustafa G, Ali J, Baboota S. Vitamin E loaded resveratrol nanoemulsion
for brain targeting for the treatment of Parkinson's disease by reducing oxidative
stress. Nanotechnology. 2014; 25(48):1–13.
Pangeni R, Ali J, Mustafa G, Sharma S, Baboota S. Design expert-supported development
and validation of stability indicating high-performance liquid chromatography (HPLC)
method for determination of resveratrol in bulk drug and pharmaceutical formulations.
International Journal of Pharmaceutical Sciences and Research. 2015; 6(12):5115–5125.
Poudel S, Pangeni R, Huo Z, Farkas D, Gulec S, Zhang Q, Lasaosa M, Tong R, Moeller
FG, Li Q, Wang Y, Qin B, Halquist MS, Xu Q. A systematic approach to develop and characterize
a compositionally equivalent buprenorphine in situ forming implant (Sublocade®). Journal of Controlled Release. 2026 Mar 4;393: 114793.
Poudel S, Qin C, Pangeni R, Hu Z, Berkbigler G, Gunawardena M, Duerfeldt AS, Xu Q.
Oral pharmacokinetic evaluation of a microemulsion-based delivery system for novel
A190 prodrugs. Biomolecules. 2025; 15: 1101.
Sudarjat H, Qin C, Ingabire D, Raynold AAM, Pangeni R, Pearcy A, Meng T, Zhao L, Arriaha
M, Chow WN, Puetzer JL, Lu X, Moeller FG, Halquist MS, O’Keeffe C, Banks ML, Xu Q.
Janus LAAM-loaded electrospun fibrous buccal fils for treating opioid use disorder.
Biomaterials. 2025; 317: 123041.
Ingabire D, Qin C, Meng T, Raynold AAM, Sudarjat H, Townsend EA, Pangeni R, Poudel
S, Arriaga M, Zhao L, Chow WN, Banks M, Xu Q. Nor-LAAM loaded PLGA microparticles
for treating opioid use disorder. Journal of Controlled Release. 2024; 373: 93-104.
Poudel S, Kaffash E, Zhao L, Pangeni R, Chow WN, Xu Q. Dexamethasone sodium phosphate
loaded nanoparticles for prevention of nitrogen mustard induced corneal injury. Experimental Eye Research. 2024; 243: 109902.
Zhang Y, Li S, Loch K, Duncan GA, Kaler L, Pangeni R, Peng W, Wang S, Gong X, Xu Q.
pH-responsive mucus-penetrating nanoparticles for enhanced cellular interlization
by local administration in vaginal tissue. ACS Macro Letters. 2023; 12(4): 446-453.
Maharjan R, Choi JU, Kweon S, Pangeni R, Lee NK, Park SJ, Chang KY, Park JW, Byun
Y. A novel oral metronomic chemotherapy provokes tumor-specific immunity resulting
in colon cancer eradication in combination with anti-PD-1 therapy. Biomaterials. 2022; 281: 121331.
Maharjan R, Subedi L, Pangeni R, Jha SK, Kang SH, Chang KY, Byun Y, Choi JU, Park
JW. Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions
for boosting tumor-specific immunity. Drug Delivery. 2021; 28910: 2313-2328.
Panthi VK, Jha SK, Chaubey R, Pangeni R. Formulation and development of Serratiopeptidase
enteric coated tablets and analytical method validation by UV Spectroscopy. International Journal of Analytical Chemistry. 2021.
Jha SK, Chung JY, Pangeni R, Choi HS, Subedi L, Kweon S, Choi JU, Byun Y, Kim YH,
Park JW. Enhanced antitumor efficacy of bile acid-lipid complex-anchored docetaxel
nanoemulsion via oral metronomic scheduling. Journal of Controlled Release. 2020; 328: 368-394.
Jha SK, Han HS, Subedi L, Pangeni R, Chung JY, Kweon S, Choi JU, Byun Y, Kim YH, Park
JW. Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating
a deoxycholic acid derivative–lipid complex. Drug Delivery. 2020; 27(1): 1501-1513.
Subedi L, Song SY, Jha SK, Lee SH, Pangeni R, Koo KT, Kim BN, Cho SS, Park JW. Preparation
of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal
Efficacy against Superficial Mycosis. Pharmaceutics. 2021; 13(5):622.
Kang KW, Pangeni R, Park JW, Lee J, Yi E. Selective loss of calretinin-poor cochlear
afferent nerve fibers in streptozotocin-induced hyperglycemic mice. Journal of Nanoscience and Nanotechnology. 2020; 20(9):5515–5519.
Choi JU, Maharjan R, Pangeni R, Jha SK, Lee NK, Kweon S, Lee HK, Chang KY, Choi YK,
Park JW, Byun Y. Modulating tumor immunity by metronomic dosing of oxaliplatin incorporated
in multiple oral nanoemulsion. Journal of Controlled Release. 2020; 322:13–30.
Maharjan R, Pangeni R, Jha SK, Choi JU, Chang KY, Choi YK, Park JW, Byun Y. Anti-angiogenic
effect of orally available pemetrexed for metronomic chemotherapy. Pharmaceutics. 2019; 11(332):1–22.
Shankar S, Pangeni R, Park JW, Rhim J-W. Preparation of sulfur nanoparticles and their
antibacterial activity and cytotoxic effect. Materials Science and Engineering: C. 2018; 92:508–517.
Park DE, Adhikari D, Pangeni R, Panthi VK, Kim HJ, Park JW. Preparation and characterization
of callus extract from Pyrus pyrifolia and investigation of its effects on skin regeneration.
Cosmetics. 2018; 5(4):1–25.
Choi SW, Pangeni R, Jung DH, Kim SJ, Park JW. Construction and characterization of
cell-penetrating peptide-fused fibroblast growth factor and vascular endothelial growth
factor for an enhanced percutaneous delivery system. Journal of Nanoscience and Nanotechnology. 2018; 18(2):842–847.
Choi SW, Pangeni R, Park JW. Nanoemulsion-based hydrogel for topical delivery of highly
skin-permeable growth factor combinations: Preparation and in vitro evaluation. Journal of Nanoscience and Nanotechnology. 2017; 17(4):2363–2369.
Choi JU, Lee SW, Pangeni R, Byun Y, Yoon IS, Park JW. Preparation and in vivo evaluation
of cationic elastic liposomes comprising highly skin-permeable growth factors combined
with hyaluronic acid for enhanced diabetic wound-healing therapy. Acta Biomaterialia. 2017; 57:197–215.
Adhikari D, Panthi VK, Pangeni R, Kim HJ, Park JW. Preparation, characterization,
and biological activities of topical anti-aging ingredients in a Citrus junos callus
extract. Molecules. 2017; 22(12)1–15.
Panth N, Paudel KR, Sharma K, Pangeni R, Karki B, Pradhan M. Formulation, in vitro
evaluation and optimization of GI floating tablet of ranitidine HCl. World Journal of Pharmacy and Pharmaceutical Sciences. 2013.3(1):1–13.
Review Papers
Pangeni R, Meng T, Poudel S, Sharma D, Hutsell H, Ma J, Rubin BK, Longest W, Hindle
M, Xu Q. Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles
to overcome the airway mucus barriers. International Journal of Pharmaceutics. 2023; 634: 122661.
Pangeni R, Sahni JK, Ali J, Sharma S, Baboota S. Resveratrol: review on therapeutic
potential and recent advances in drug delivery. Expert Opinion on Drug Delivery. 2014; 11(8):1285–1298.
Pangeni R, Kang S, Jha SK, Subedi L, Park JW. Intestinal membrane transporter-mediated
approaches to improve oral drug delivery. Journal of Pharmaceutical Investigation. 2021; 51: 137–158.
Imran M, Jha LA, Hasan N, Shrestha J, Pangeni R, Parvez N, Mohammed Y, Jha SK, Paudel
KR. Nanodecoys-Future of drug delivery by encapsulating nanoparticles in natural cell
membranes. International Journal of Pharmaceutics. 2022; 621: 121790.
Book Chapters
Paudel KR, Panth N, Pangeni R, Awasthi R, Chawla V, Mehta M, Tambuwala MM, Hansbro
PM. Targeting lung cancer using advanced drug delivery systems. Elsevier Academic Press. Chapter 23; 493–509.
Pangeni R, Xu Q, Rubin B. Gardenhire 11e: Rau's Respiratory Care Pharmacology, Chapter
9: Mucus-Controlling Drug Therapy. Submitted for new edition 2022.
Patents
Xu Q, Pangeni R, Dale Farkas, Poudel S, Adapter for In Vitro Release Testing of Long-Acting
Injectables, Method of Manufacture Thereof, and Method of Use Thereof,” VCU XU-25-086F,
(INVENTION), Aug 20, 2025.
Xu Q, Pangeni R, Hsu K, Lowrey P, Murtagh O. Liposome compositions of DAGLB inhibitors
and their methods of use thereof. Patent pending, UT Tech ID # 8476 HSU, Filed on
07/22/2024.
Xu Q, Pangeni R, Poudel S. Damaj I, Duerfeldt AS. PPARα agonist loaded microemulsion
for oral delivery: compositions and methods of use thereof. Patent pending, 63/706,994,
Filed on 10/14/2024.
Xu Q, Pangeni R, Das SK, Fisher PB. MDA-9 single and dual PDZ domain targeted inhibitors
loaded microemulsion compositions and methods of use thereof. Patent pending, FIS-24-085F,
Filed on 10/04/2024.
Xu Q, Pangeni R, Kaffash E, Liang W, Ma J. Novel PPARα agonist loaded microemulsion
compositions and methods of use thereof. Patent pending, 63544460, Filed on 11/18/2023.
Training
- Training in Neurotherapeutics Discovery and Development for Academic Scientists 2022
-Supported by the National Institute of Neurological Disorders and Stroke (NINDS)
at UC Davis Conference Center, California.
