Dr. Shashidharamurthy's initial interest in teaching started during his training towards obtaining a PhD degree. Upon entering the Ph.D program, the most influential of his mentors were those who successfully achieved a career by combining teaching with research. As a graduate student, Dr. Shashidharamurthy learned to appreciate the aspects of teaching and research that an academic career could provide. In addition to teaching, he has also been involved in mentoring and supervising many work-study students, research assistants and postdoctoral fellows.
PhD, Department of Biochemistry, University of Mysore, India, 2004
MS, Department of Biochemistry, University of Mysore, India, 1996
BS, University of Mysore, India, 1994
At PCOM-SOP, Dr. Shashidharamurthy involved in teaching the following courses to PharmD
students.
PHAR 224G Immunology and Microbiology (coordinator)
PHAR 150G Biochemistry
PHAR 351G Toxicology
PHAR 312G Integrated Therapeutics
One of the major focuses of Dr. Shashidharamurthy's research is to delineate the molecular mechanism(s) lipocalin-2 (Lcn2) during various autoimmune/inflammatory disorders such as arthritis and lupus. This may eventually lead to development of novel therapeutic approaches. More recently his research has shown that Lcn2 plays a protective role during the pathogenesis of immune-complex mediated arthritis (Arthritis Rheum. 2013;65:1064-73). The preliminary data suggests that Lcn2 knockout mice are defective in the production of anti-inflammatory cytokines and T reg expansion during arthritis condition. These results demonstrate that Lcn2 is a host-protective factor against systemic autoimmune disease. Apart from this project, our laboratory is also focused on: The individual role of FcGamma receptor and complement proteins during the pathogenesis of immune-complex (IC) mediated vasculitis (funded by American Heart Association), Attenuation of IC-mediated inflammation by prostaglandin E2 receptor antagonists and Synergistic effect of IC’s and TLR ligands during IC-mediated inflammatory disorders.
Role: Principal Investigator
Award type: Scientist Development Grant Program
Funding source: American Heart Association
Title: Blocking of immune-complex mediated vasculitis using recombinant Fc receptors.
Duration: 1/1/2011-12/31/2015
Role: Principal Investigator
Award type: Internal funding
Funding Agency: (Chief Scientific officer) CSO-funding
Title: Synergistic effect of immune-complex and TLR ligand during immune-complex mediated
disorders.
Duration: 12/1/2012-12/31/2013
Role: Principal Investigator
Award type: Internal funding
Funding Agency: CSO-funding for MS-Thesis
Title: Attenuation of antibody- mediated inflammation by prostaglandin E2 receptor
antagonists during autoimmune arthritis.
Duration: 08/1/2012-08/31/2014
Role: Co Principle investigator
Award type: Internal funding
Funding Agency: CSO-funding
Title: Attenuation of immune-complex mediated inflammation through inhibition of NFkb
activation by caffeic acid phenethyl ester (CAPE).
Duration: 12/17/2013-11/30/2015
Early career Faculty Award from American Association of Immunologist (2013 - 2015)
American Association of Immunologist Trainee Awards. 2011 (two awards for two different
presentations)
Scientist Development grant program Award from America Heart Association. 2011
American Association of Immunologist. 2005- present
American College of Clinical Pharmacy (ACCP). 2012- present
American Association for the Advancement of Science. 2005-2010
a. Biochimie 2004- Present
b. Comparative Biochemistry and physiology, 2004- present
c. Planta Medica, 2006- present
d. Nutrition Journal, 2007- present
e. Current Medicinal Chemistry, 2008-present
f. Immunopharmacology And Immunotoxicology, 2008-present
g. Archives of Biochemistry and Biophysics, 2009-present
h. Bioorganic & Medicinal Chemistry Letters, 2010-present
i. European Journal of Cancer 2013-Present
j. Clinical and Applied Thrombosis/Hemostasis 2013-present
k. Cellular Physiology and Biochemistry, 2014-present
l. Plose One, 2015-present
Serving as active committee member on American Heart Association Grant review committee under Vascular Endothelial Biology and Function - Basic Science and Immunology and Virology - Basic Science study sections
Renowned speaker and Chairing the session (Track:5 Allergy) at 4th international conference on Clinical and Experimental Dermatology too be held at San Antonio, Texas, USA. April 14-16, 2014.
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