RANGAIAH SHASHIDHARAMURTHY, PHD
Department of Pharmaceutical Sciences
Associate Professor


Rangaiah Shashidharamurthy

Contact

Email: rangaiahsh@pcom.edu
Office: 678-407-7373
Publications and Selected Works

Affiliations

Adjunct Faculty at Department of Pathology, Emory University, Atlanta, GA. USA.

Dr. Shashidharamurthy's initial interest in teaching started during his training towards obtaining a PhD degree. Upon entering the Ph.D program, the most influential of his mentors were those who successfully achieved a career by combining teaching with research. As a graduate student, Dr. Shashidharamurthy learned to appreciate the aspects of teaching and research that an academic career could provide. In addition to teaching, he has also been involved in mentoring and supervising many work-study students, research assistants and postdoctoral fellows.

  • Education

    PhD, Department of Biochemistry, University of Mysore, India, 2004
    MS, Department of Biochemistry, University of Mysore, India, 1996
    BS, University of Mysore, India, 1994

  • Courses

    At PCOM-SOP, Dr. Shashidharamurthy involved in teaching the following courses to PharmD students.

    PHAR 224G Immunology and Microbiology (coordinator)
    PHAR 150G Biochemistry
    PHAR 351G Toxicology
    PHAR 312G Integrated Therapeutics

  • Research

    One of the major focuses of Dr. Shashidharamurthy's research is to delineate the molecular mechanism(s) lipocalin-2 (Lcn2) during various autoimmune/inflammatory disorders such as arthritis and lupus. This may eventually lead to development of novel therapeutic approaches. More recently his research has shown that Lcn2 plays a protective role during the pathogenesis of immune-complex mediated arthritis (Arthritis Rheum. 2013;65:1064-73). The preliminary data suggests that Lcn2 knockout mice are defective in the production of anti-inflammatory cytokines and T reg expansion during arthritis condition. These results demonstrate that Lcn2 is a host-protective factor against systemic autoimmune disease. Apart from this project, our laboratory is also focused on: The individual role of FcGamma receptor and complement proteins during the pathogenesis of immune-complex (IC) mediated vasculitis (funded by American Heart Association), Attenuation of IC-mediated inflammation by prostaglandin E2 receptor antagonists and Synergistic effect of IC’s and TLR ligands during IC-mediated inflammatory disorders.

  • Grants

    Role: Principal Investigator
    Award type: Scientist Development Grant Program
    Funding source: American Heart Association
    Title: Blocking of immune-complex mediated vasculitis using recombinant Fc receptors.
    Duration: 1/1/2011-12/31/2015

    Role: Principal Investigator
    Award type: Internal funding
    Funding Agency: (Chief Scientific officer) CSO-funding
    Title: Synergistic effect of immune-complex and TLR ligand during immune-complex mediated disorders.
    Duration: 12/1/2012-12/31/2013

    Role: Principal Investigator
    Award type: Internal funding
    Funding Agency: CSO-funding for MS-Thesis
    Title: Attenuation of antibody- mediated inflammation by prostaglandin E2 receptor antagonists during autoimmune arthritis.
    Duration: 08/1/2012-08/31/2014

    Role: Co Principle investigator
    Award type: Internal funding
    Funding Agency: CSO-funding
    Title: Attenuation of immune-complex mediated inflammation through inhibition of NFkb activation by caffeic acid phenethyl ester (CAPE).
    Duration: 12/17/2013-11/30/2015

  • Awards

    Early career Faculty Award from American Association of Immunologist (2013 - 2015)

    American Association of Immunologist Trainee Awards. 2011 (two awards for two different presentations)

    Scientist Development grant program Award from America Heart Association. 2011

  • Memberships

    American Association of Immunologist. 2005- present
    American College of Clinical Pharmacy (ACCP). 2012- present
    American Association for the Advancement of Science. 2005-2010

    Editorial Service

    a. Biochimie 2004- Present
    b. Comparative Biochemistry and physiology, 2004- present
    c. Planta Medica, 2006- present
    d. Nutrition Journal, 2007- present
    e. Current Medicinal Chemistry, 2008-present
    f. Immunopharmacology And Immunotoxicology, 2008-present
    g. Archives of Biochemistry and Biophysics, 2009-present
    h. Bioorganic & Medicinal Chemistry Letters, 2010-present
    i. European Journal of Cancer 2013-Present
    j. Clinical and Applied Thrombosis/Hemostasis 2013-present
    k. Cellular Physiology and Biochemistry, 2014-present
    l. Plose One, 2015-present

    Grant Review Study Section Member

    Serving as active committee member on American Heart Association Grant review committee under Vascular Endothelial Biology and Function - Basic Science and Immunology and Virology - Basic Science study sections

    Invited Speaker at National/International Conferences

    Renowned speaker and Chairing the session (Track:5 Allergy) at 4th international conference on Clinical and Experimental Dermatology too be held at San Antonio, Texas, USA. April 14-16, 2014.