Department of Pharmaceutical Sciences
Assistant Dean for Professional and Student Affairs
Associate Professor

Michael J. Lee, PhD


Research Page

Dr. Lee is originally from New Hampshire and earned a BS degree in biochemistry from the University of New Hampshire and a PhD degree in Neuroscience at the University of Colorado Health Sciences Center (UCHSC) in Denver, CO. Prior to earning his PhD, he was employed at Xenometrix, Inc., in Boulder, CO, a biotechnology start-up company, developing cell- and gene expression-based toxicity assays. Dr. Lee completed a post-doctoral training fellowship at UCHSC School of Pharmacy utilizing genetically selected inbred mice to identify candidate genes underlying rapid behavioral tolerance to alcohol. Dr. Lee completed post-doctoral work at the Institute for Behavioral Genetics (IBG) at the University of Colorado in Boulder, CO, studying complex behavioral traits related to drugs of abuse utilizing nicotinic receptor knock-out animals. Dr. Lee has published peer-reviewed research articles in the areas of molecular toxicology, pharmacology, behavioral genetics and schizophrenia.

Prior to coming to PCOM in 2011, Dr. Lee held a faculty appointment in the Department of Pharmaceutical Sciences at the Appalachian College of Pharmacy (ACP), in Oakwood, VA. He taught several courses including cell biology, biochemistry, pharmacology and immunology. In addition to his faculty appointment, he served two years as Assistant Dean of Student and Alumni Affairs at ACP overseeing admissions, academic support services, and career and professional development of pharmacy students.

  • Education

    PhD, Neuroscience, University of Colorado Health Sciences Center, 2004
    BS, Biochemistry, University of New Hampshire, 1992

  • Courses

    Integrated Therapeutics I
    Integrated Therapeutics III
    Integrated Therapeutics IV

  • Publications

    Selected Publications

    Araud T, Graw S, Berger R, Lee M, Neveu E, Bertrand D, Leonard S. The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochemical Pharmacology, 82(8): 904-914, 2011.

    Sinkus ML*, Lee MJ*, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base pair Deletion Polymorphism in the Partial Duplication of the Alpha7 Nicotinic Acetylcholine Gene (CHRFAM7A) on Chromosome 15q14 is Associated with Schizophrenia. Brain Research. 1291:1-11, 2009.
    * indicates authors contributed equally to manuscript.

    Radcliffe RA, Floyd KL, and Lee MJ. Rapid Ethanol Tolerance Mediated by Adaptations in Acute Tolerance in Inbred Mouse Strains. Pharmacology, Biochemistry and Behavior, 84(3): 524-534, 2006

    Radcliffe, RA, Lee MJ and Williams RW. Prediction of cis-QTLs in a Pair of Inbred Mouse Strains with the Use of Expression and Haplotype Data from Public Databases. Mammalian Genome. 17(6):629-642, 2006

    Lee MJ, Breese CR, Strook, ML, Leonard S. The Effect of Nicotine and Haloperidol Co-treatment on Nicotinic Receptor Levels in the Rat Brain. Brain Research. Molecular Brain Research. 86(1-2): 115-24, 2001.

    Breese CR, Lee MJ, Adams CE, Sullivan B, Logel J, Marks MJ, Collins AC, Leonard S. Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia. Neuropsychopharmacology. 23(4): 351-64, 2000.

    Selected Presentations

    Lee MJ, Zolman, KL, Lintz, LC, Radcliffe, RA. Microarray Analysis of Transcription Factor Activation Patterns in Inbred Long and Short Sleep Mice During Acquisition of Rapid Tolerance to Ethanol. National Institute on Alcohol Abuse and Alcoholism NIAAA Trainee Workshop, Indianapolis Alcohol Research Center, Indianapolis, IN, 2005

  • Memberships

    American Association of Colleges of Pharmacy (AACP)