Publications and Abstracts
N. Sang, D. Stiehl, J. Bohensky, I. Leshchinsky, V. Srinivas, J. Caro. (2003) MAPK
Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on
p300. J. Biol. Chem 278: 14013-14019.
Terkhorn, S., Bohensky, J., Ohashi, M., Shapiro, I.M., Jacquet, R., Koyama, E., Landis,
W., Adams, CS and Srinivas, V. (2005) Growth plate terminal differentiation is regulated
by oxemic status and the HIF-PHD axis. Proceedings of the 8th International Conference
on Mineralized Tissues, Baniff, Canada pp 54-56.
Bohensky, J, Shapiro I.M., Leshinsky S, Terkhorn S.P., Adams C.S., Srinivas V. (2007)
HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway. Autophagy
Terkhorn, SP, Bohensky, J, Shapiro, IM, Koyama E., Srinivas V. (2007) Expression of
HIF prolyl hydroxylase isozymes in growth plate chondrocytes: Relationship between
maturation and apoptotic sensitivity J. Cell. Physiol. Jan: 210 (1): 257-65.
J. Bohensky, I.M. Shapiro, S. Leshinsky, H. Watanabe, V. Srinivas (2007): PIM-2 is
an Independent Regulator of Chondrocyte Survival and Autophagy in the Epiphyseal Growth
Plate J Cell Physiol, 213:246-251.
Shapiro, I.M., Snyder, B., Freeman, T., Watanabe, H., Bohensky, J., Fertala, J., and
Srinivas, V. (2007) Chondrocyte maturation is characterized by an interplay between
Uncoupler Protein-3 (UCP-3) and the hypoxic environment of the growth plate Proceedings
of the International Mineralized Tissue Society, Chile pp 51-58.
Watanabe, H., Bohensky, J., Freeman, T., Srinivas, V., Shapiro, I.M. (2007) Hypoxic
Induction of UCP3 in the Growth Plate: UCP3 Suppresses Chondrocyte Autophagy. UCP3
Suppresses Chondrocyte Autophagy: J Cell Physiol. 216; 419-425 (2008).
Vickram Srinivas, Jolene Bohensky, Irving M Shapiro: Autophagy: A New Phase in the
Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase:
Cells Tissues Organs. 189; 88-92 (2009).
Vickram Srinivas, Jolene Bohensky, Adam M. Zahm and Irving M. Shapiro: Autophagy in
mineralizing tissues: Microenvironmental perspectives. Cell Cycle. 8; 391-393 (2009).
Bohensky, J., Shapiro I.M., Leshinsky, S., Srinivas, V. Autophagy in Epiphyseal Chondrocytes:
Regulation by AMPK and mTOR: Pediatric Nephrology 2010 Apr; 25(4):633-42.
Bohensky, J., Terkhorn, S.P., Freeman, T.A., Adams, C.S., Garcia, J.A., Shapiro, I.M.,
Srinivas, V.: Regulation of Autophagy in the Epiphyseal Growth Plate: HIF-2 Suppresses
Chondrocyte Autophagy and Promotes Maturation. Arthritis & Rheumatism. 60: 1406-1415
Raihana Zaka, Arnold S Dion, Anna Kusnierz, Jolene Bohensky, Vickram Srinivas, Theresa
Freeman, Charlene J Williams: Oxygen Tension Regulates the Expression of ANK (progressive
ankylosis) in a Hif-1-Dependent Manner in Growth Plate Chondrocytes: Journal of Bone
and Mineral Research, 10.1359/jbmr.090512 (2009).
Jeremy Price, Asifa K. Zaidi, Jolene Bohensky, Vickram Srinivas, Irving M Shapiro
and Hydar Ali. Akt-1 Mediate Survival of Chondrocytes from Endoplasmic Reticulum-induced
Stress. J Cell Physiol. 222; (3): 502-508 (2010).
Jolene Bohensky, Deanna C. Lee, Harvey Smith, Adam Zahm, Christopher S. Adams, Vickram
Srinivas, Theresa Freeman. Hypoxia, Nutrient Deprivation, TNF-alpha and Aging: All
Induce Autophagy in Nucleus Pulposus Cells and Increases Their Susceptibility to Apoptogens.
(Arthritis and Rheumatism, Dec. 2010).
Zahm, A., Bohensky, J., Shapiro, I.M., Srinivas, V, Adams, C.: Bone Cell Autophagy
Is Regulated by Environmental Factors. Cells, Tissues, and Organs, Jan 2011.
Jolene Bohensky, Shawn Terkhorn, Hitoshi Watanabe, Serge Leshinsky, Irving M Shapiro,
Vickram Srinivas (2005) The epiphyseal growth plate: survival and death decisions
at the HIF-Akt axis. Sigma Xi Student Research Day, Thomas Jefferson University, Philadelphia,
Shawn Terkhorn, Jolene Bohensky, Masaru Ohashi, Irving M. Shapiro, Robin Jaquet, Eiki
Koyama, William Landis, Christopher S. Adams, and Vickram Srinivas (2005) Growth plate
terminal differentiation is regulated by oxemic status and the HIF-PHD axis: 8th International
Conference on Mineralized Tissue, Baniff, Canada.
Hitoshi Watanabe, Bradley Snyder, Jolene Bohensky, Theresa Freeman, Irving M Shapiro
and Vickram Srinivas (2005) HIF-1 mediated stimulation of UCP3 in growth plate chondrocytes:
Effect on proliferation, maturation and mineralization: International Conference on
Tissue Mineralization, Santiago, Chile.
Terkhorn, S., Bohensky, J., Shapiro, I.M., Srinivas, V. (2006) HIF-2 is required for
chondrocytes maturation, ROS dismutation and suppression of autophagy: 28th Annual
Meeting, ASBMR, Philadelphia, PA.
Bohensky, J., Leshinsky, S., Terkhorn, S.P., Shapiro, I.M., Srinivas, V. (2006) HIF-1
regulation of chondrocyte apoptosis: induction of the autophagic pathway: 28th Annual
Meeting, ASBMR, Philadelphia, PA (2006).
Srinivas, V., Bohensky, J., Shapiro, I.M. (2007) Autophagy a New Phase in the Maturation
of Growth Plate Chondrocytes is regulated by HIF-1, mTOR, and AMP Kinase (AMPK), 9th
International Conference on Chemistry and Biology of Mineralized Tissue, Austin, TX.
Zaka, R., Dion A.S., Kusnierz, A., Bohensky, J., Srinivas, V, Williams, C.J. (2007)
Expression of ANK is Sensitive to Oxygen. OARSI World Congress on Osteoarthritis,
Fort Lauderdale, FL.