Jolene Bohensky, MS, PA-C joined the Physician Assistant (PA) Studies program in November of 2017. Bohensky, earned her Bachelor of Science degree in Biology from the University of Scranton and a Master of Science degree in Microbiology from Thomas Jefferson University. She spent eight years conducting research for the departments of medicine and orthopedics at Jefferson University Hospital. Her research focused on the molecular mechanisms of chondrocyte survival in the growth plate.
During her tenure at Jefferson, her research led to several first author publications. She then wanted to bridge her scientific background to clinical medicine, which led her to pursue a master of science degree in physician assistant studies. Her background includes experience in family medicine, urology and student health. Aside from practicing clinically, she served as a guest lecturer and preceptor to physician assistant students.
Bohensky is a graduate of the PCOM Physician Assistant Studies program, class of 2012. She is a nationally board certified physician assistant and is licensed to practice medicine in the state of Pennsylvania. She currently maintains her clinical practice in family medicine.
N. Sang, D. Stiehl, J. Bohensky, I. Leshchinsky, V. Srinivas, J. Caro. (2003) MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300. J. Biol. Chem 278: 14013-14019.
Terkhorn, S., Bohensky, J., Ohashi, M., Shapiro, I.M., Jacquet, R., Koyama, E., Landis, W., Adams, CS and Srinivas, V. (2005) Growth plate terminal differentiation is regulated by oxemic status and the HIF-PHD axis. Proceedings of the 8th International Conference on Mineralized Tissues, Baniff, Canada pp 54-56.
Bohensky, J, Shapiro I.M., Leshinsky S, Terkhorn S.P., Adams C.S., Srinivas V. (2007) HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway. Autophagy 3(3): 207-214.
Terkhorn, SP, Bohensky, J, Shapiro, IM, Koyama E., Srinivas V. (2007) Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: Relationship between maturation and apoptotic sensitivity J. Cell. Physiol. Jan: 210 (1): 257-65.
J. Bohensky, I.M. Shapiro, S. Leshinsky, H. Watanabe, V. Srinivas (2007): PIM-2 is an Independent Regulator of Chondrocyte Survival and Autophagy in the Epiphyseal Growth Plate J Cell Physiol, 213:246-251.
Shapiro, I.M., Snyder, B., Freeman, T., Watanabe, H., Bohensky, J., Fertala, J., and Srinivas, V. (2007) Chondrocyte maturation is characterized by an interplay between Uncoupler Protein-3 (UCP-3) and the hypoxic environment of the growth plate Proceedings of the International Mineralized Tissue Society, Chile pp 51-58.
Watanabe, H., Bohensky, J., Freeman, T., Srinivas, V., Shapiro, I.M. (2007) Hypoxic Induction of UCP3 in the Growth Plate: UCP3 Suppresses Chondrocyte Autophagy. UCP3 Suppresses Chondrocyte Autophagy: J Cell Physiol. 216; 419-425 (2008).
Vickram Srinivas, Jolene Bohensky, Irving M Shapiro: Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase: Cells Tissues Organs. 189; 88-92 (2009).
Vickram Srinivas, Jolene Bohensky, Adam M. Zahm and Irving M. Shapiro: Autophagy in mineralizing tissues: Microenvironmental perspectives. Cell Cycle. 8; 391-393 (2009).
Bohensky, J., Shapiro I.M., Leshinsky, S., Srinivas, V. Autophagy in Epiphyseal Chondrocytes: Regulation by AMPK and mTOR: Pediatric Nephrology 2010 Apr; 25(4):633-42.
Bohensky, J., Terkhorn, S.P., Freeman, T.A., Adams, C.S., Garcia, J.A., Shapiro, I.M., Srinivas, V.: Regulation of Autophagy in the Epiphyseal Growth Plate: HIF-2 Suppresses Chondrocyte Autophagy and Promotes Maturation. Arthritis & Rheumatism. 60: 1406-1415 (2009).
Raihana Zaka, Arnold S Dion, Anna Kusnierz, Jolene Bohensky, Vickram Srinivas, Theresa Freeman, Charlene J Williams: Oxygen Tension Regulates the Expression of ANK (progressive ankylosis) in a Hif-1-Dependent Manner in Growth Plate Chondrocytes: Journal of Bone and Mineral Research, 10.1359/jbmr.090512 (2009).
Jeremy Price, Asifa K. Zaidi, Jolene Bohensky, Vickram Srinivas, Irving M Shapiro and Hydar Ali. Akt-1 Mediate Survival of Chondrocytes from Endoplasmic Reticulum-induced Stress. J Cell Physiol. 222; (3): 502-508 (2010).
Jolene Bohensky, Deanna C. Lee, Harvey Smith, Adam Zahm, Christopher S. Adams, Vickram Srinivas, Theresa Freeman. Hypoxia, Nutrient Deprivation, TNF-alpha and Aging: All Induce Autophagy in Nucleus Pulposus Cells and Increases Their Susceptibility to Apoptogens. (Arthritis and Rheumatism, Dec. 2010).
Zahm, A., Bohensky, J., Shapiro, I.M., Srinivas, V, Adams, C.: Bone Cell Autophagy Is Regulated by Environmental Factors. Cells, Tissues, and Organs, Jan 2011.
Jolene Bohensky, Shawn Terkhorn, Hitoshi Watanabe, Serge Leshinsky, Irving M Shapiro, Vickram Srinivas (2005) The epiphyseal growth plate: survival and death decisions at the HIF-Akt axis. Sigma Xi Student Research Day, Thomas Jefferson University, Philadelphia, PA.
Shawn Terkhorn, Jolene Bohensky, Masaru Ohashi, Irving M. Shapiro, Robin Jaquet, Eiki Koyama, William Landis, Christopher S. Adams, and Vickram Srinivas (2005) Growth plate terminal differentiation is regulated by oxemic status and the HIF-PHD axis: 8th International Conference on Mineralized Tissue, Baniff, Canada.
Hitoshi Watanabe, Bradley Snyder, Jolene Bohensky, Theresa Freeman, Irving M Shapiro and Vickram Srinivas (2005) HIF-1 mediated stimulation of UCP3 in growth plate chondrocytes: Effect on proliferation, maturation and mineralization: International Conference on Tissue Mineralization, Santiago, Chile.
Terkhorn, S., Bohensky, J., Shapiro, I.M., Srinivas, V. (2006) HIF-2 is required for chondrocytes maturation, ROS dismutation and suppression of autophagy: 28th Annual Meeting, ASBMR, Philadelphia, PA.
Bohensky, J., Leshinsky, S., Terkhorn, S.P., Shapiro, I.M., Srinivas, V. (2006) HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway: 28th Annual Meeting, ASBMR, Philadelphia, PA (2006).
Srinivas, V., Bohensky, J., Shapiro, I.M. (2007) Autophagy a New Phase in the Maturation of Growth Plate Chondrocytes is regulated by HIF-1, mTOR, and AMP Kinase (AMPK), 9th International Conference on Chemistry and Biology of Mineralized Tissue, Austin, TX.
Zaka, R., Dion A.S., Kusnierz, A., Bohensky, J., Srinivas, V, Williams, C.J. (2007) Expression of ANK is Sensitive to Oxygen. OARSI World Congress on Osteoarthritis, Fort Lauderdale, FL.