Email: francisje@pcom.edu
Office: 678-225-7562
Research Page
Dr. Jenney teaches biochemistry, molecular biology and genetics in both the biomedical
and the osteopathic medicine programs. According to Dr. Jenney, in order to understand
human biology "mind, body and spirit", it is critical to understand the molecular
mechanisms which are the foundation. In order to incorporate scientific thinking and
evidence-based medicine, Dr. Jenney includes recent scientific literature in his lectures. He
covers topics including basic metabolism, the human microbiota, nutritional biochemistry
and the genetics of various diseases such as cardiac diseases, neurological disorders
and cancer.
The research in his lab involves the study of metalloproteins from hyperthermophiles—highly
stable proteins which hold great promise for both medical and commercial processes.
In particular, he is looking at utilizing these proteins as potential treatments for
cancer and ischemia/reperfusion injury, as well as the potential role of hydrogenases
in biofuel production.
PhD, University of Pennsylvania, Philadelphia, PA
Selected Publications
Kamali, S., H. Wang, D. Mitra, H. Ogata, W. Lubitz*, B.C. Manor, T.B. Rauchfuss, D.
Byrne, V. Bonnefoy, F.E. Jenney Jr., M.W.W. Adams, Y. Yoda, E. Alp, J. Zhao, and S.P.
Cramer. 2013. Active Site Fe-CN and Fe-CO Vibrations in [NiFe] Hydrogenase – Observation
by Nuclear Resonance Vibrational Spectroscopy. Angewandte Chem. Int. Ed. Engl. 52:724-728.
Chandrayan, S.K., P.M. McTernan, R.C. Hopkins, J. Sun, F.E. Jenney, Jr., and M.W.W.
Adams. 2012. Engineering hyperthermophilic archaeon Pyrococcus furiosus to overproduce
its cytoplasmic [NiFe]-hydrogenase. J. Biol. Chem. 287:3257-3264.
Hopkins, R.C., J. Sun, F.E. Jenney, Jr., S.K. Chandrayan, P.M. McTernan, and M.W.W.
Adams. 2011. Homologous expression of a subcomplex of Pyrococcus furiosus hydrogenase
that interacts with pyruvate ferredoxin oxidoreductase. PLoS ONE. 6:e26569.
Lipscomb, G.L., K. Stirrett, G.J. Schut, F. Yang, F.E. Jenney, Jr., R.A Scott, M.W.W.
Adams, and J. Westpheling. 2011. Natural competence in the hyperthermophilic archaeon
Pyrococcus furiosus facilitates genetic manipulation: construction of multiple markerless
deletions of genes encoding the two cytoplasmic hydrogenases. Appl. Environ. Microbiol.
77(7):2232-2238.
Cvetkovic, A., A.L. Menon, M.P. Thorgersen, J.W. Scott, F.L. Poole, II, F.E. Jenney,
Jr., W.A. Lancaster, J.L. Praissman, S. Shanmukh, B.J. Vaccaro, S.A. Trauger, E. Kalisiak,
J.V. Apon, G. Siuzdak, S.M. Yannone, J.A. Tainer, and M.W.W. Adams. 2010. The Metalloproteomes
of Microorganisms are Largely Uncharacterized. Nature. 466:779-782.
Sun, J., R.C. Hopkins, F.E. Jenney, Jr., P. McTernan, and M.W.W. Adams. 2010. Heterologous
expression and maturation of an NADP-dependent [NiFe]-Hydrogenase: A Key Enzyme in
Biofuel Production. PLoS One. 5:e10526.
Hura, G.L., A.L. Menon, M. Hammel, R. Rambo, F.L. Poole II, S. Tsutakawa, F.E. Jenney,
Jr., S. Classen, K.A. Frankel, R.C. Hopkins, S.J. Yang, J.W. Scott, B. Dillard, M.W.W.
Adams, and J.A. Tainer. 2009. Robust, high-throughput solution structural analyses
by small angle X-ray scattering (SAXS). Nature Methods. 6:606-612.
Menon, A.L., F.L. Poole, II, A. Cvetkovic, S.A. Trauger, E. Kalisiak, J.W. Scott,
S. Shanmukh, J. Praissman, F.E. Jenney, Jr., W.R. Wikoff, J.V. Apon, G. Siuzdak, and
M.W.W. Adams. 2009. Novel Multiprotein Complexes Identified in the Hyperthermophilic
Archaeon Pyrococcus furiosus by Non-denaturing Fractionation of the Native Proteome.
Molec. Cell. Proteomics. 8:735-751.
Chou, C.-J., F.E. Jenney, Jr., M.W.W. Adams, and R.M. Kelly. 2008. Hydrogenesis in
hyperthermophilic microorganisms: Implications for biofuels. Metabolic Engineer. 10:393-404.
Jenney, Jr., Francis E. and M.W.W. Adams. (2008) Hydrogenases of the model hyperthermophiles.
Annals NY Acad. Sci. 1125:252-266.
Jenney, Jr., F.E. and M.W.W. Adams. 2007. The impact of extremophiles on structural
genomics (and vice versa). Extremophiles. 12:39-50.
Poole, F.L. II, B.A. Gerwe, R.C. Hopkins, G.J. Schut, M.V. Weinberg, F.E. Jenney,
Jr., M.W.W. Adams. 2005. Defining genes in the genome of the hyperthermophilic archaeon
Pyrococcus furiosus: implications for all microbial genomes. J. Bacteriol. 187:7325-7332.
Sugar, F.J., F.E. Jenney, Jr., F.L. Poole II, P.S. Brereton, M. Izumi, C. Shah, M.W.W.
Adams. 2005. Comparison of small-and large-scale expression of selected Pyrococcus
furiosus genes as an aid to high-throughput protein production. J. Struct. Funct.
Genomics. 6:149-158.
Jenney, Jr., F.E., P.S. Brereton, M. Izumi, F.L. Poole II, C. Shah, F.J. Sugar, H.-L.
Lee, and M.W.W. Adams. 2005. High-throughput production of Pyrococcus furiosus proteins:
considerations for metalloproteins. J. Synch. Rad. 12:8-12.
Grunden, A.M., F.E. Jenney, Jr., K. Ma, M. Ji, M.V. Weinberg, M.W.W. Adams. 2005.
In vitro reconstitution of an NADPH-dependent superoxide reduction pathway from Pyrococcus
furiosus. Appl. Environ. Microbiol. 71:1522-1530.
Tempel, W., Z.J. Liu, F.D. Schubot, A. Shah, M.V. Weinberg, F.E. Jenney, Jr., W.B.
Arendall 3rd, M.W.W. Adams, J.S. Richardson, D.C. Richardson, J.P. Rose, and B.C.
Wang. 2004. Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals
3D domain swapping in rubrerythrin. Proteins 57:878-882.
Chatake, T., K. Kurihara, I. Tanaka, I. Tsyba, R. Bau, F.E. Jenney, Jr., M.W.W. Adams,
and N. Niimura. 2004. A neutron crystallographic analysis of a rubredoxin mutant at
1.6 A resolution. Acta Crystallogr. D Biol. Crystallogr. 60:1364-1373.
Bergmann U., W. Sturhahn, D.E. Linn Jr., F.E. Jenney, Jr., M.W. Adams, K. Rupnik,
B.J. Hales, E.E. Alp, A. Mayse, and S.P. Cramer. 2003. Observation of Fe-H/D modes
by nuclear resonant vibrational spectroscopy. J Am Chem Soc. 125:4016-4017.
Clay M.D., C.A. Cosper, F.E. Jenney, Jr., M.W. Adams, and M.K. Johnson. 2003. Nitric
oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide
reductase. Proc Natl Acad Sci U S A. 100:3796-3801.
Adams M.W., F.E. Jenney, Jr., M.D. Clay, and M.K. Johnson. 2002. Superoxide reductase:
fact or fiction? J Biol Inorg Chem. 7:647-52.
Jenney, F.E. Jr., and M.W. Adams. 2001. Rubredoxin from Pyrococcus furiosus. Methods
Enzymol. 334:45-55.
Adams M.W., J.F. Holden, A.L. Menon, G.J. Schut, A.M. Grunden, C. Hou, A.M. Hutchins,
F.E. Jenney, Jr., C. Kim, K. Ma, G. Pan, R. Roy, R. Sapra, S.V. Story, M.F. Verhagen.
2001. Key role for sulfur in peptide metabolism and in regulation of three hydrogenases
in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol. 183:716-724.
Jenney, Jr., F.E., M.F.J.M. Verhagen, X. Cui, M.W.W. Adams. 1999. Anaerobic microbes:
oxygen detoxification without superoxide dismutase. Science 286:306-309.
Selected Presentations
October 25, 2013 “Genetic marker testing – new directions”. Georgia Osteopathic Medical
Association, Annual CME Convention, Suwanee, GA.
June 12, 2010 “What's coming down the tract - the growing roles of diet, flora, and
genetics in treatment of GI diseases”. Georgia Osteopathic Medical Association, Annual
CME Convention, Hilton Head, SC.
July 30, 2007 “Multiple NiFe-Hydrogenases in the Hyperthermophile Pyrococcus furiosus”.
Society for Industrial Microbiology, Annual Meeting, Denver, CO.
July 10, 2007 “The Pathway and Enzymology of Hydrogen Production by Thermotoga maritima”.
Thermotoga Workshop 2007, California Institute for Telecommunications and Information
Technology (Calit2), San Diego, CA.
January 12, 2005 "Development of high-throughput methods for expression screening
and protein purification using the model organism Pyrococcus furiosus". Protein Process
Development meeting, Cambridge Healthtech Institute, San Diego, CA
June 29, 2003 "HTP - multifaceted expression and protein purification system using
Pyrococcus furiosus". Second BioXAS Study Weekend: Genomics and BioXAS, Orsay, France
Advisor for GA PCOM Green Team and Alpha Epsilon Lambda Graduate Honor Society
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