Department of Pharmaceutical Sciences
Chair and Professor

Avadesh C. Sharma, PharmD, PhD


Email: avadheshsh@pcom.edu
Office: 678-407-7344
Research Page

Dr. Sharma has more than 20 years of extensive experience in research and teaching of cardiovascular physiology and pharmacology.

Dr. Sharma has been instrumental in developing the infrastructure for research at the School of Pharmacy duly supported by PCOM. In a newly-developed Pharmacy Research Laboratory at the Georgia campus, Dr. Sharma is developing an in vitro paradigm (using stem cell derived cardiomyocyte and primary human cardiomyocyte culture) to assess in vivo clinical cardiovascular pathophysiology. Dr. Sharma envisions advancing the Department of Pharmaceutical Sciences as a platform for the growth and development of students and faculty at the PCOM School of Pharmacy - Georgia Campus.

As a member of Executive Leadership Team of the PCOM School of Pharmacy, Dr. Sharma is integral part of accreditation process (governed by Accreditation Council of Pharmacy Education). Dr. Sharma is leading the department of pharmaceutical sciences in providing education to professional PharmD students at the School of Pharmacy.

  • Research

    In his search for clinical biomarkers for the early stages of congestive heart failure, Dr. Sharma’s research is focused on apoptosis and the signaling cascade that occur with sepsis-induced myocardial dysfunction. In addition to intramural resources, Dr. Sharma’s research had been funded through the National Heart, Lung and Blood Institute of NIH, American Heart Association and Oral & Maxillofacial Research Foundation.

  • Publications

    Selected Publications


    Ph. D.: Studies on Neurotransmitter and Receptor Mechanisms in Learning and Memory and Related Behaviours: Influence of Centrally Acting Drugs

    Master of Pharmacy: Role of Oxygen Free Radicals in Calcium Paradox and Ischaemia Reperfusion Injury

    Refereed Journal Supplements*, Books and Book Chapters

    *Advances in Systemic Inflammatory Response: Avadhesh C. Sharma, Editor: Frontiers in Bioscience (http://www.bioscience.org/current/special/sharma.htm) Volume 10, 11 &14; Special Issue.

    Role of Endothelin in Regional Vascular System: Avadhesh C. Sharma and Anil Gulati in Endothelin: Role in Health and Disease, edited by A. Gulati. Harwood Academic Publishers gmbh, Amsterdam, The Netherlands, 1995: 215-232.

    Biological Activities of Endothelin and Their Clinical Significance: Govind Singh, Avadhesh C. Sharma, Sam Rebello and Anil Gulati in Endothelin: Role in Health and Disease, edited by A. Gulati. Harwood Academic Publishers gmbh, Amsterdam, The Netherlands, 1995: 99-116.

    Refereed Journal Publications (Selected)

    Chopra M, Golden HB, Mullapadi S, Dowhan W, Dostal DE, Sharma AC, Modulation of myocardial mitochondrial mechanisms during severe polymicrobial sepsis in the rat. PLoS ONE 2011;6(6):e21285. Epub 2011 Jun 21.

    Chopra M, Reuben JS, Sharma AC. Acute lung injury: apoptosis and signaling mechanisms. Exp Biol Med (Maywood). 2009 Apr; 234(4):361-71. Epub 2009 Jan 28. Review. PubMed PMID: 19176873.

    Gupta A, Aberle NS 2nd, Kapoor R, Ren J, Sharma AC. Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility in sepsis. Biochim Biophys Acta. 2005 Jun 30; 1741(1-2):127-39. Epub 2005 Apr 2. PubMed PMID: 15955456.

    Ren J, Ren BH, Sharma AC. Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties. Shock. 2002 Sep; 18(3):285-8. PubMed PMID: 12353932.

    Sharma AC, Motew SJ, Farias S, Alden KJ, Bosmann HB, Law WR, Ferguson JL. Sepsis alters myocardial and plasma concentrations of endothelin and nitric oxide in rats. J Mol Cell Cardiol. 1997 May; 29(5):1469-77. PubMed PMID: 9201631.

    Sharma AC, Singh G, Gulati A. Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats. Am J Physiol. 1995 Oct; 269(4 Pt 2):H1379-88. PubMed PMID: 7485571.

    Sharma AC, Kulkarni SK. Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice. Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jan; 16(1):117-25. PubMed PMID: 1557503.

  • Memberships

    President: Association of Scientists of Indian Origin in America, Inc. (ASIOA), 2010-2012 Fourth National meeting of ASIOA (Suwanee, GA, Jan 15-17, 2011)

    Vice-President: Third National meeting of ASIOA, January 17-19, 2009, Denton, TX

    Managing Editor: Frontiers in Bioscience, Encyclopedia in Bioscience, Volume 10-11, 2005-2006. Advances in Systemic Inflammatory Response

  • Grants

    • Sharma A.C., Principal Investigator, Ketamine-mediated modulation of NMDA and opioid receptors on activated platelets, CCDA, PCOM, 2010-2012.
    • Sharma A.C., Co-Investigator (David Grogan, PI), Low-dose Ketamine (intraoperative) decreases postoperative opioid use. Oral Maxillofacial Research Foundation, 2010-2011.
    • Sharma A.C., Principal Investigator, Endothelin converting enzyme in sepsis: cardiac function. NHLBI, 2006-2008.
    • Sharma A.C., Principal Investigator “Interactive Endothelin and Nitric Oxide Mechanisms in Myocardial Dysfunction in Sepsis.” Beginning Grant in Aid, Northland Affiliate, American Heart Association, 2002-2004.