Opioid Use Disorder Patients Report Higher Rates of SuicidalityJune 13, 2023
More than 37% of adults receiving office-based treatment for opioid use disorder (OUD)
reported experiencing suicidal thoughts over their lifetime, and 27% reported attempting
suicide, rates that are “notably higher” than the general population (15.6% and 5%,
respectively), according to a Philadelphia College of Osteopathic Medicine study that also identifies predictors for suicidality in people with OUD. The findings
may better identify at-risk patients and inform mental health prevention and treatment
“The elevated rates of lifetime suicidality found in individuals in recovery from
opioid use disorder suggest the need for regular screening for suicidal thoughts in
this patient group,” said lead author Michelle R. Lent, PhD, an associate professor of Clinical Psychology at PCOM. “These findings also underscore the importance of multifaceted addiction
treatment approaches that address mental health issues and other psychosocial concerns,
in addition to substance misuse.”
The study, published this month in Addiction Science & Clinical Practice, examines the prevalence of, and factors associated with, suicidality in adults with
OUD who initiated office-based treatment for the medication buprenorphine, which is
associated with improvements in suicide risk, due in part to its “potential to minimize
pain-induced aversive moods” and its “ability to foster engagement in medical care,”
according to the study.
While medications such as buprenorphine are “effective and lifesaving,” mental health
issues associated with OUD can take people away from their recovery goals, Lent said,
emphasizing that OUD intervention “has to be more than medication.”
In the study, 244 adults completed semi-structured interviews about their mental health
experiences. All were enrolled in clinical trials for OUD treatment at Federally Qualified
Health Centers in Pennsylvania or New Jersey that are affiliated with the Greater
Philadelphia Opioid Use Disorder Research Group.
Lifetime depression, anxiety, physical or sexual abuse, having a chronic pain-related
condition (such as arthritis or migraine), lifetime use of more than one drug, being
on parole or probation, and years of education correlated with suicidality. Respondents
of Hispanic or Latinx ethnicity reported elevated rates of suicidal ideation and attempts.
Lent said a topic of future inquiry for addiction researchers could be more exploration
of why people of Hispanic or Latinx ethnicity may be at greater risk than the general
“Given the very high prevalence of lifetime suicidality in our sample, regular screening
and monitoring for suicidality may be warranted” in people starting medication-based
treatment for OUD “given the challenges in multiple life domains that can accompany
both OUD and recovery,” the authors wrote, concluding that office-based OUD clinics
“would benefit from integrated behavioral health services that can improve clinical
response to the mental health needs of patients.”
This research was supported by funding from the Patient-Centered Outcomes Research
Institute (lead institution, Philadelphia College of Osteopathic Medicine) and the
Pennsylvania Department of Health (lead institution, Public Health Management Corporation)
for two ongoing clinical trials from which this study was conducted.
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About Philadelphia College of Osteopathic Medicine
Founded in 1899, Philadelphia College of Osteopathic Medicine (PCOM) has trained thousands
of highly competent, caring physicians, health practitioners and behavioral scientists
who practice a “whole person” approach to care—treating people, not just symptoms.
PCOM operates three campuses (PCOM, PCOM Georgia and PCOM South Georgia) and offers doctoral degrees in clinical psychology, educational psychology, osteopathic
medicine, pharmacy, physical therapy and school psychology, and graduate degrees in
applied behavior analysis, applied positive psychology, biomedical sciences, forensic
medicine, medical laboratory science, mental health counseling, non profit leadership
and population health management, organizational development and leadership, physician
assistant studies, school psychology, and public health management and administration.
PCOM students learn the importance of health promotion, research, education and service
to the community. Through its community-based Healthcare Centers, PCOM provides care
to medically underserved populations. For more information, visit pcom.edu or call 215-871-6100.
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