Yun Bai, PhD
Assistant Professor of Pharmaceutical Sciences
PhD, Pharmaceutical Sciences, University of Southern California, 2006
MS Biochemistry and Molecular Biology, Tsinghua University, China, 2000
BS Pharmacy, Peking University Health Science Center, China, 1997
Dr. Bai has coordinated and taught in courses Pharmaceutics (PHAR 141G), Pharmaceutics
Lab (PHAR 162G), Biologics and Biopharmaceutic (PHAR 374 EG). She also participated
in teaching courses in Biopharmaceutics (PHAR 169G), Pharmacokinetics (PHAR 227G),
Physiology & Pathophysiology II (PHAR 114G)
Dr. Bai been working in the field of drug delivery for many years. Her contributions
to the advancement of science are best documented through publications in scientific
journals. She has a total of 16 research papers in international, peer-reviewed journals,
including the world-renowned scientific journal Proc Natl Acad Sci US. Dr. Bai's first
authored paper was published in the high-profile journal PNAS and also was featured
in the Research Highlights section of Nature Review Drug Discovery. Since Dr. Bai
joined PCOM, she has published 6 manuscripts in peer-reviewed scientific journals,
including first authorship and coordinating authorship.
2012, Peach Teaching Award
School of Pharmacy, Philadelphia College of Osteopathic Medicine
2006, Outstanding Research Assistant Award
University of Southern California, School of Pharmacy
2005, Invited as the only student speaker
USC-AAPS 2005 Symposium Moving Targets
2005, Bai et al., Proc Natl Acad Sci USA. 102(20): 7292-6 was featured in the Research
Highlights section of Nature Review Drug Discovery 4, 537 (2005).
2005, Abstract nominated for Innovative Aspects of Oral Drug Delivery and Absorption
Controlled Release Society (CRS)
2004, Graduate Student Award in the AAPS Graduate Symposium in Drug Delivery and Pharmaceutical
American Association of Pharmaceutical Scientists (AAPS)
2004, Second Place Award in poster section
USC-AAPS 2004 Symposium Moving Targets
Sachdeva V, Bai Y, Kydonieus A, Banga AK. (2013) Formulation and optimization of desogestrel transdermal
contraceptive patch using crystallization studies. Int J Pharm. 441(1-2):9-18.
Yu T, Bai Y. (2013) Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic
Networks. Current Metabolomics. 1(1): 84-91.
Vemulapalli V, Bai Y, Kalluri H, Herwadkar A, Kim H, Davis SP, Friden PM, Banga AK. (2013) In vivo iontophoretic
delivery of salmon calcitonin across microporated skin. J Pharm Sci. 101(8):2861-9
Yu T#, Bai Y#. (2011) Improving gene expression data interpretation by finding latent factors
that co-regulate gene modules with clinical factors. BMC Genomics. 12:563. (# joint
Yu T#, Bai Y#. (2011) Capturing Changes in Gene Expression Dynamics by Gene Set Differential Coordination
Analysis. Genomics. 98(6):469-77. (# joint correspondence author)
Chen X, Bai Y, Zaro J, Shen WC. (2010) Design of an in vivo cleavable disulfide linker in recombinant
fusion proteins. Biotechniques. 49(1): 513-8.
Bai Y, Shen WC. (2006) Improving the oral efficacy of recombinant granulocyte colony-stimulating
factor and transferrin fusion protein by spacer optimization. Pharm Res. 23(9):2116-21.
Bai Y, Ann DK, Shen WC. (2005) Recombinant granulocyte colony-stimulating factor-transferrin
fusion protein as an oral myelopoietic agent. Proc Natl Acad Sci U S A. 102(20):7292-6.
Widera A, Bai Y, Shen WC. (2004) The transepithelial transport of a G-CSF-transferrin conjugate in
Caco-2 cells and its myelopoietic effect in BDF1 mice. Pharm Res. 21(2):278-84.
Bai Y, Zhao Y, Yu T, Dierich MP, Chen YH. (2000) Antibodies to HIV-1 gp41 recognize synthetic
peptides of human IFN-alpha and IFN-beta. Int Arch Allergy Immunol. 121(2): 170-2.
Yu T, Bai Y, Dierich MP, Chen YH. (2000) Induction of high levels of epitope-specific antibodies
by epitope/peptide candidate vaccines against human immunodeficiency virus type-1
(HIV-1). Microbiol Immunol. 44(2): 105-10.
Yu T, Xiao Y, Bai Y, Ru Q, Luo G, Dierich MP, Chen Y. (2000) Human interferon-beta inhibits binding of
HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein
P50 for HIV-1 gp41. Immunol Lett. 73(1):19-22.
Chen YH, Bai Y, Yu T, Dierich MP. (1999) Modulation of major histocompatibility complex antigen
expression by human immunodeficiency virus-2 gp36. Immunol Lett. 68(2-3): 415-7.
Chen YH, Yu T, Bai Y, Dierich MP. (1999) Immunogenicity of the GPGRAFY epitope on synthetic peptides.
Immunol Lett. 69(3): 353-4.
Chen YH, Yu T, Bai Y, Zhao N. (1999) Two proteins share immunological epitopes on the tumor-associated
antigen 17-1A. Cancer Lett. 144(1): 101-5.
Bai Y, Yu T, Zhao Y, Xiao Y, Yang Y, Chen YH. (1999) A novel putative tumor associated
antigen. Tsinghua Sci. & Tech. 4(3): 1568-9.
Work in Progress
Bai Y, Kim H, Friden P, and Banga AK. Confocal study of transdermal delivery of albumin
by microneedles and Iontophoresis. (In submission)
Shen WC, Bai Y, Ann DK, and Widera A. US Patent Pending No. 20090042777: G-CSF-Tranferrin Fusion
Bai Y, Banga, AK. Transmembrane Delivery of Peptides and Protein with Combination of Iontophoreis
and Microporation. PepCon, Protein & Peptide Conference. Beijing, China, 2011.
Bai Y, Shen WC. Oral Delivery of Therapeutic Proteins. AAPS-University of Southern California,
Moving Targets, the 4TH Annual Multidisciplinary Scientific Symposium, Los Angeles,
Bai Y, Shen WC. Transferrin Receptor –Mediated Oral Delivery of Therapeutic Proteins: a
Study of G-CSF-Transferrin Fusion Protein. AAPS Annual Meeting, Baltimore, Maryland,
Support from Center of Science Officer (CSO), 2012-2013 ($4500)
Intramural Research Grant, Philadelphia College of Osteopathic Medicine, Center for
Chronic Disorders of Aging (CCDA), Philadelphia, PA, 2011-2012 ($9500)