RUTH C. BORGHAEI, PHD
Department of Bio-Medical Sciences - Philadelphia
Professor of Biochemistry and Molecular Biology


Ruth C. Borghaei, PhD

Contact

Email: ruthb@pcom.edu
Office: 215-871-6454
Research Page

Dr. Ruth Borghaei is a Professor in the Department of Biomedical Sciences.

  • Education

    PhD, Microbiology and Immunology, Temple University School of Medicine, 1992
    BS, (with highest distinction), Microbiology, University of Maine, 1987

    Dr. Borghaei completed postdoctoral studies at the Institute for Cancer Research of the Fox Chase Cancer Center in Philadelphia.

  • Courses

    Dr. Borghaei is director of the Molecular Basis of Medicine course in the Masters in Biomedical Sciences program and also teaches molecular biology and genetics to those students and to first-year DO students.

  • Research

    Dr. Borghaei's research interest is in transcriptional regulation of gene expression, particularly in response to inflammation. In addition, her lab is also interested in studying mechanisms behind epigenetic changes that occur in chronic inflammation, and may be involved in increased risk of carcinogenesis.

  • Publications

    Publications

    Chambers, M, Kirkpatrick, G, Evans, M, Gorski, G, Foster, S and Borghaei, RC (2013) IL-4 inhibition of IL-1 induced Matrix Metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal Kinase (JNK) Exp. Cell Res. 319:1398. NIHMS ID 470770

    Borghaei, R.C. and Chambers, M. (2009) Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines. Pathol. Lab. Med. Int. 1:7.

    Borghaei, R.C., Gorski, G., Javadi, M. and Chambers, M. (2009) NF-ƙB and ZBP-89 regulate MMP-3 expression via a polymorphic site. Biochem. Biophys. Res. Comm. 382(2009):269. NIHMSID 171948

    Stewart, DK, Javadi, M., Chambers, M, Gunsolly, C, Gorski, G and Borghaei, RC (2007) Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARγ activation in human gingival fibroblasts. BMC Molecular Biology 8:12 PMC1810308

    Borghaei, R.C., Rawlings, P.L. Jr., Javadi, M. and Woloshin, J. (2004) NF-B binds to a polymorphic repressor element in the MMP-3 promoter. Biochem. Biophys. Res. Comm. 316:182-188. PMC1595538

    Jenkins, K, Javadi, M., and Borghaei, R.C. (2004) Interleukin-4 suppresses interleukin-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts. J. Periodontol. 75:267-275. PMC1595536

    Daghigh, F., Borghaei, R.C., Thornton, R.D. and Bee. J.H. (2001) Human gingival fibroblasts produce nitric oxide in response to pro-inflammatory cytokines. J. Periodontol. 73:392-400.

    Thornton, R.D., Lane, P., Borghaei, R.C., Pease, E.A., Caro, J., and Mochan, E. (2000) Interleukin-1 induces hypoxia inducible factor-1 in human gingival and synovial fibroblasts. Biochem. J. 350:307-312.

    Gorski, G.K., Paul, M., SooHoo, H., Borghaei, R.C., Mochan, E., Thornton, R. and Pease, E. (1999) Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display. Inflamm Res. 48:S122-123

    Borghaei, R.C., Sullivan, C. and Mochan, E. (1999) Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3). J. Biol. Chem. 274:2126-2131. PMC1595537

    Borghaei, R.C., Sinai, R.S., Mochan, E. and Pease, E.A. (1998) Mitogen-inducible nuclear orphan receptor (MINOR) is induced by interleukin 1 in human synovial and gingival fibroblasts. Biochem. Biophys. Res. Comm., 251:334-338.

    Fowler, M.J. Jr., Neff, M.S., Borghaei, R.C., Pease, E.A., Mochan, E. and Thornton, R.D. (1998) Induction of bone morphogenetic protien-1 by interleukin 1 in human fibroblasts. Biochem. Biophys. Res. Comm., 248:450-453.

    Borghaei, R.C., Rawlings P.L., Jr. and Mochan, E. (1998) Interleukin 4 suppression of interleukin 1 induced transcription of collagenase (MMP-1) and stromelysin (MMP-3) in human synovial fibroblasts. Arthritis and Rheum., 41:1398-1406. PMC1602062

    Ni, X., Borghaei, H., Borghaei, R.C., Thornton, R.D., Pease, E. and Mochan, E. (1997) DGLA discoordinately supresses IL-1 induced metalloproteinase mRNA levels in human synovial fibroblasts. Inflamm. Res. 46: S124-126.

    Borghaei, H, Borghaei, R.C., Ni, X., Pease, E., Thornton, R. and Mochan, E. (1997) Inhibition of IL-1 induced Collagenase expression by dihomo-Ɣ-linolenic acid (DGLA) may be mediated by inhibition of NFƙB binding. Inflamm Res. 46:S177-178.

    Soprano, D.R., Chen, L.X., Wu, S., Donigan, A.M., Borghaei, R.C. and Soprano, K.J. (1996) Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition. Oncogene 12:577-584

    Carter, R., Yumet, G., Pena, A. Soprano, D.R. and Soprano, K.J. (1994) Transcriptional regulation of c-jun expression during late G1/S in normal human cells is lost in human tumor cells. Oncogene 9:2675-2682.

    Carter, R., Cosenza, S., Pena, A., Lipson, K. Soprano, D.R. and Soprano, K.J. (1991) A potential role for c-jun in cell cycle progression through late G1 and S. Oncogene 6:229-235.

    Holthius, J., Owen, T.A., van Wijnen, A., Wright, K.L., Ramsey-Ewing, A., Kennedy, M.B., Carter, R., Cosenza, S.C., Soprano, K.J., Lian, J.B., Stein, J.L. and Stein, G.S. (1990) Tumor cells exhibit deregulation of the cell cycle controlled proliferation specific histone gene promoter factor hinf-D. Science 247:1454-1457.

  • Memberships

    Dr. Borghaei is a member of the PCOM chapter of Sigma Xi, the American Society for Biochemistry and Molecular Biology and the American Society of Genetics.

  • Grants

    Previous grant funding and current application:

    6/25/15 NIH-NIDCR, Principal Investigator
    Regulation of DNA methylation and demethylation by inflammatory cytokines

    7/1/10 to 6/30/11 CCDA, PCOM Principal Investigator
    Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells.

    9/1/04 to 8/31/10 NIH R15 DE16277 Principal Investigator
    Transcriptional regulation of matrix metalloproteinase 3
    [Research Supplement to Promote Diversity in Health-related Research, 2005-2006]

    8/1/97 to 5/31/03 NIH R29 DE12096-01 Principal Investigator
    IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
    [Supplement for Underrepresented Minorities, 2000-2001]

    9/15/95 to 7/14/97 NIH RO3 DE11577-01 Principal Investigator
    IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts