LINDON H. YOUNG, PHD
Department of Bio-Medical Sciences - Philadelphia
Professor of Microbiology and Immunology


Lindon H. Young, PhD

Contact

Email: lindonyo@pcom.edu
Office: 215-871-6832
Research Page

Lindon H. Young is the director of the Pharmacology course in the Biomedical Sciences MS program and teaches in selected courses in the DO program at PCOM.

Dr. Young specializes in the area of cardiovascular pharmacology and has mentored over 63 MS and DO/PhD students and four PCOM residents from 2002 to present on various research projects that range from cellular based assays to human studies.

Dr. Young’s training has helped our students accomplish educational and research objectives, and continues to strive to improve the quality of teaching and mentorship to our Biomedical Sciences and DO students to pass standardized tests (e.g. Medical board exams) by having an integrative session that requires class participation via the use of the “clicker” system. Such a system enables us to immediately evaluate the classroom’s understanding of the pharmacology material. This system has proven to be effective and the classroom appears to enjoy the presentation of the material.

Dr. Young has also mentored PCOM residents that have been hired as Clinical Research Associates in our myocardial I/R drug development program.

  • Education

    PhD, Pharmacology, Philadelphia College of Pharmacy and Science, 1998
    BA, Biology/Psychology, Immaculata College, 1986
    AS, Hotel/Food Service Management, Pennsylvania State University, 1980

  • Research

    Dr. Young is a Research Investigator at PCOM who has conducted research related to myocardial ischemia-reperfusion (I/R) injury and to evaluate mechanisms related to oxidative stress that initiate I/R injury. Such research would have clinical value to heart attack and coronary bypass patients where limited pharmacological intervention is available. He received his postdoctoral training in the laboratories of Drs Margaret Weis and Allan Lefer where he conducted research related to myocardial I/R injury.

    Thereafter, Dr. Young started his academic research career at PCOM in 2002. The first study was conducted using a broad-spectrum protein kinase C (PKC) inhibitor, Gö6983, which was shown to increase vascular nitric oxide (NO) release and inhibit leukocyte surperoxide (SO release). This tool served as an effective prognostic indicator for the general role of PKC regulation in I/R injury. Then he started to use selective PKC isoform inhibitors and activators that differentially regulate eNOS and NADPH oxidase activities as they relate to myocardial I/R. Subsequently, the remarkable results of PKC epsilon peptide inhibitor have led me to further explore the role of eNOS uncoupling as a key mechanism in myocardial I/R injury that transcends both rat and porcine species. PCOM has also been awarded US and worldwide patents regarding the PKC isoform peptide modulators such as PKC epsilon inhibitor. Dr. Young has collaborated with many other investigators both intra and extramurally on a wide array of research projects that range from evaluating the role of genetic markers in myocardial developmental biology to OMT-based research in patients.


    Research Keywords

    Myocardial ischemia/reperfusion injury
    Endothelial nitric oxide synthase
    Hydrogen peroxide
    Nitric oxide
    Vascular endothelial dysfunction
    Leukocyte-endothelial interactions
    Hyperglycemia
    Inflammation
    Oxidative stress

  • Awards

    2013-2014 Professor of the Year Award presented by the PCOM DO Class of 2017.

    P.C.O.M. has been granted U.S. (PKC beta II peptide inhibitor, filing date: 09/28/2007; patent awarded: 08/25/2011) and European (PKC epsilon peptide inhibitor, filing date: 12/11/2006; patent awarded: 05/10/2012) patents pertaining to the development of a preservation/perfusion solution that can be used in patients with acute coronary syndromes that include but are not limited to myocardial infarction, angina, coronary bypass/angioplasty and organ transplantation. –role on patents: Inventor

    1999-2001 National Heart, Lung & Blood Institute Training Grant HL-07599NHH, National Service Research Award

  • Publications

    Selected Publications

    Allan M. Prior, Man Zhang, Nina Blakeman, Palika Datta, Hung Pham, Qian Chen, Lindon H. Young, Margaret T. Weis, Duy H. Hua. Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury. Bioorganic & Medicinal Chemistry Letters 24 (4):1057-1061, 2014.

    Matthew Montgomery, Jovan Adams, Jane Teng, Biruk Tekelehaymanot, Regina Ondrasik, Issachar Devine, Kerry-Anne Perkins, Qian Chen, Robert Barsotti, and Lindon H. Young. Myristoylated protein kinase C epsilon peptide inhibitor exerts cardioprotective effects in rat and porcine myocardial ischemia/reperfusion: A translational research study. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 178-179, 2013.

    Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.

    Alexandra C. Lopez, Qian Chen, Brittany L. Deiling, Edward S. Iames, Robert Barsotti, and Lindon H. Young. The Effects of Modulating Endothelial Nitric Oxide Synthase (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 58-59, 2013.

    T. Galbreath, Q. Chen, R. Ondrasik, M. Bertolet, R. Barsotti, L. Young. Effects of Mitochondrial-Targeted Antioxidants on Real-time Nitric Oxide and Hydrogen Peroxide Release in Hind Limb Ischemia and Reperfusion (I/R). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 46-47, 2013.

    Issachar Devine, Qian Chen, Regina Ondrasik, William Chau, Katelyn Navitsky, On Say Lau, Christopher W. Parker, Kyle D. Bartol, Brendan Casey, Robert Barsotti, Lindon H. Young. Cardioprotective Effects of Cell Permeable NADPH oxidase inhibitors in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 42-43, 2013.

    Matthew L. Bertolet, Michael Minni, Tyler Galbreath, Robert Barsotti, Lindon H. Young, and Qian Chen. Effects of Selective NADPH Oxidase Inhibitors on Real-Time Blood Nitric Oxideand Hydrogen Peroxide Release in Acute Hyperglycemia. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 34-35, 2013.

    Hung T. Pham, Robert Barsotti, Amber N. Koon, Brian Rueter, Lindon H. Young, and Qian Chen. The Role of NADPH Oxidase on L-NAME-induced Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 66-67, 2013.

    Regina Ondrasik, Qian Chen, Katelyn Navitsky, William Chau, Issachar Devine, On S. Lau,Tyler Galbreath, Robert Barsotti, and Lindon H. Young. Cardioprotective Effects of Mitochondrial-Targeted Antioxidants in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 64-65, 2013.

    Nina Blakeman, Qian Chen, Jasmine Tolson, Brian Rueter, Brian Diaz, Brendan Casey, Lindon H. Young, Margaret T. Weis. Triacsin C, a Fatty Acyl CoA Synthetase Inhibitor, Improves Cardiac Performance Following Global Ischemia. Am. J. Biomed. Sci., 4(3), 249-261, 2012.

    Kerry-Anne A. Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S. Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Iyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng and Lindon H. Young. The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). Naunyn-Schmiedeberg’s Arch of Pharmacol 385(1):27-38, 2012.



    Selected Presentations

    Lindon H. Young, Christopher W. Parker, Robert Barsotti, Kyle D. Bartol, Tsion Habamu, Jasmine Tolson, Deima Koko, Brian Diaz, Brendan Casey, Regina Ondrasik, Qian Chen, Justin Miller, Amanda Miller, Jaclyn Milici. Apocynin exerts dose-dependent cardioprotective effects by attenuating reactive oxygen species (ROS) in ischemia/reperfusion (I/R). Federation of American Societies for Experimental Biology, 27: 1191.1, 2013.

    Brittany L. Deiling, Edward S. Iames, Kerry-Anne Perkins, Qian Chen, Lindon H. Young. Tetrahydrobiopterin attenuates extracorporeal shock wave lithrotripsy-induced blood nitric oxide level reduction in the renal vein. Federation of American Societies for Experimental Biology, 26: 1137.5, 2012.

    Kyle D. Bartol, Tsion Habtamu, Jasmine Tolson, Deima Koko, Brian Diaz, Ryan Murphy, Qian Chen and Lindon H. Young. Apocynin exerts cardioprotection in ischemia-reperfusion by inhibiting superoxide release from NADPH oxidase. Federation of American Societies for Experimental Biology, 26: 1136.16, 2012.

    Margaret T. Weis, Jasmine Tolson, Qian Chen and Lindon H. Young. Triacsin C, a fatty acyl CoA synthetase inhibitor, improves cardiac performance following global ischemia. Federation of American Societies for Experimental Biology, 26: 1136.18, 2012.

    Christopher W. Parker, Kyle D. Bartol, Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Effects of NADPH oxidase inhibitor apocynin on real-time blood hydrogen peroxide release in femoral artery/vein ischemia and reperfusion. Federation of American Societies for Experimental Biology, 26: 678.8, 2012.

    Amber Koon, Maria Kern, Lindon H. Young, Brian Rueter, Edward Iames and Qian Chen. The effects of modulating eNOS activity and coupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Federation of American Societies for Experimental Biology, 26: 680.12, 2012.

    Maria A. Kern, Lindon H. Young, Brian Rueter, Edward S. Iames, Qian Chen. The role of endothelial nitric oxide synthase (eNOS) uncoupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Federation of American Societies for Experimental Biology, 25: 638.4, 2011.

    Kyle D. Bartol, Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Effects of protein knase C broad spectrum inhibitor Gö 6983 on real-time blood nitric oxide and hydrogen peroxide release in femoral artery/vein ischemia and reperfusion. Federation of American Societies for Experimental Biology, 25: 639.4, 2011.

    Edward S. Iames Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Real-time measurement of free radicals in renal veins from exposure to extracorporeal shock wave lithotripsy treatment. Federation of American Societies for Experimental Biology, 25: 667.10, 2011.

    Michael Minni, Qian Chen, Kyle Bartol, Kerry-Anne Perkins, Brian Rueter and Lindon H. Young. The real-time measurements of blood nitric oxide and hydrogen peroxide levels under acute hyperglycemia. Federation of American Societies for Experimental Biology, 25: 821.21, 2011.

    Nina Blakeman, Qian Chen, Lindon Young and Margaret Weis. Evidence that fatty acyl CoA synthetase is a mediator of ischemia/reperfusion injury in the rat. Federation of American Societies for Experimental Biology, 25: 821.32, 2011.

  • Grants

    Pennsylvania State Tobacco Grant 01/01/2012-12/31/2015
    Title: Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues
    Role on Project: Principal Investigator

    In vivo and ex vivo mechanisms related to eNOS uncoupling during Reperfusion (Funded by the National, Heart, Lung and Blood Institute of the NIH from 4/1/08 – 3/31/11 # 2 R15 HL076235-02): SFS RR4 to the NIH
    Role on Project: Principal Investigator

    Center for Chronic Disorders of Aging (CCDA) at PCOM Lindon Young, Ph D (PI) 01/01/2009-10/31/2010 Tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2) in leukocyte-endothelium interactions by using intravital microscopy

    Center for Chronic Disorders of Aging at PCOM Lindon Young, PhD (PI) 1/1/2008 12/31/2008 Administration of Protein Kinase C Beta II Inhibitor During Extracorporeal Shock Wave Lithotripsy Reduces Free Radical Production
    Role on Project: PI

    Protein Kinase C isoform inhibition in cardiac ischemia/reperfusion (Funded by the National, Heart, Lung and Blood Institute of the NIH from 3/18/04 – 2/28/07 # 1 R15 HL076235
    Role on Project: Principal Investigator at P.C.O.M

    Proposed role of endothelial long chain fatty acyl CoA synthetase in the development of post-menopausal hypertension (Funded by Women’s Health Research Institute, Texas Tech University Health Sciences Center (TTUHSC) at Amarillo from 4/2004 – 3/2006)
    Role on Project: Co-Principal Investigator with Margaret T. Weis (TTUHSC)

     

  • Other

    Volunteer and Leadership Activities
    • Journal of Renin-Angiotensin-Aldosterone-System (2012-present)
    • Journal of Cellular Physiology (2007-present)
    • Journal of Pharmacology and Experimental Therapeutics (2005-present)
    • Biochemica et Biophysica Acta-Proteins and Proteomics (2004-present)
    • British Journal of Pharmacology (2004-present)