Department of Bio-Medical Sciences - Philadelphia
Associate Professor of Biochemistry and Molecular Biology

Dianzheng Zhang, PhD


Email: dianzhengzh@pcom.edu
Office: 215-871-6588
Research Page

Dr. Zhang’s general interest is the nutrient control of gene expression in health and disease. Particularly, he is interested in the regulation of gene expression by micronutrients, such as vitamins and minerals, as well as phytochemicals.

As living organisms, we continuously exchange chemical components with the environment; the exchange nutrients are implicated in the regulation of gene expression and cell fates, which ultimately confer life or death. With increasing knowledge of the importance of nutrition in our aging population, medicine is shifting its focus from treatment of acute diseases, to the prevention of cancer and chronic diseases. It has been estimated that thirty to fifty percent of all chronic diseases are preventable by attention to dietary factors.

Present research projects in his laboratory are focused on, but not limited to, the (1) molecular mechanisms of chemo-preventive effects of different phytochemicals, especially resveratrol, in prostate cancer development, (2) mechanisms of resveratrol effects on tensin expression and prostate cancer, and (3) the underlying molecular mechanisms of TMPRSS fusion with ETS transcriptional factors (ERG in particular) in cancer prevention and gene therapy.

  • Education

    PhD, Nutritional Science, The University of Arizona, Tucson, 2001
    MS, Biochemistry, Hunan Medical University, Changsha, P. R. China, 1987
    BS, Chemistry, Qufu Teaching University Qufu, Shandong, P. R. China

  • Courses

    Dr. Zhang teaches the following courses: Introduction to Medical Biochemistry and Molecular Biology, Medical Biochemistry and Molecular Biology, and Cellular and Molecular Basis of Medicine (CMBM). Dr. Zhang’s courses cover the following content areas: hormonal regulation of metabolisms, ATP and energy generation, dietary carbohydrate metabolism, dietary proteins, fatty acid synthesis, and lipoproteins.

  • Research

    Research Keywords

    Prostate cancer
    Androgen receptor

  • Awards

    2008 Visiting Professor: Changsha Medical College, Hunan Province, PRC

    2007 Visiting Professor: Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

    2006 Young Researcher Scholarship for AICR/WCRF International Research Conference on Food, Nutrition and Cancer (2006, Washington, D.C.) American Institute of Cancer Research and World cancer Research Fund International

    2005 Outstanding Performance and Excellence in Scientific Presentation The 2005 Texas Chapter Annual Symposium

    2003 Award for Excellent Presentation of Research Society of Chinese Biochemists in America, Texas Chapter

    1990 Advanced Research Award Hunan province, P. R. China

    1989 Excellent Teaching Award Hunan Medical University, P. R. China

  • Publications

    Selected Publications

    Zhifeng Ning, Jinfeng Gan, Chaoying Chen, Dianzheng Zhang, Hao Zhang (2014) Molecular functions and significance of the MTA family in hormone-independent cancer. Cancer and Metastasis Review 2014 Oct 24. [Epub ahead of print]

    Xiaoshen Sun, Zainul S. Hasanali, Allshine Chen, Dianzheng Zhang, Xin Liu, Hong-Gang Wang, David J. Feith, Thomas P. Loughran Jr and Kailin Xu (2014) Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia. British Journal of Hematology 2014 Oct 4. doi: 10.1111/bjh.13143. [Epub ahead of print]

    Wei Zhao, Cunjie Chang, Yangyan Cui, Xiaozhi Zhao, Jun Yang, Lan Shen, Ji Zhou, Zhibo Hou, Zhen Zhang, Changxiao Ye, Donald Hasenmayer, Robert Perkins, Xiaojing Huang, Xin Yao, Like Yu, Ruimin Huang, Dianzheng Zhang, Hongqian Guo, Jun Yan (2014) Steroid Receptor Coactivator-3 Regulates Glucose Metabolism in Bladder Cancer Cells through Coactivation of Hypoxia Inducible-Factor 1α. Journal of Biological Chemistry 2014 Apr 18; 289 (16):11219-29 (ePub ahead)
    Weihua Lan, Dianzheng Zhang, Jun Jiang (2013) The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells Medical Hypotheses Sep 8. doi:pii: S0306-9877(13)00439-8 10.1016/j.mehy.2013.09.005. [Epub ahead of print]

    Xin-xing Wan, Hanchun Chen, Md. Asaduzzaman Khan, Ai-hua Xu, Fu-lan Yang, Yun-yi Zhang and Dianzheng Zhang (2013) ISG15 Inhibits IFN-α Resistant Liver Cancer Cell Growth BioMed Research International (in print)

    Md. Asaduzzaman Khan, Han-chun Chen, Dianzheng Zhang, Junjiang Fu (2013) Twist: a molecular target in cancer therapeutics Tumor Biology 34 (5): 2497-2506

    Fang-dan Ouyang, Fu-lan Yang, Han-chun Chen, Md. Asaduzzaman Khan, Feng-mao Huang, Xin-xing Wan, Ai-hua Xu, Xing Huang, Mei-juan Zhou, Qian Fang, Dian-zheng Zhang (2013) Polymorphisms of DNA repair genes XPD, XRCC1 and OGG1, and lung adenocarcinoma susceptibility in Chinese population Tumor Biology 34 (5):2843-8

    Selected Presentations

    Combating prostate cancer by targeting androgen receptor with phytochemical resveratrol. BIT’s 3rd Annual World Cancer Congress-2010-Breast Cancer Congress (Fighting Breast Cancer at Molecular Level), Shanghai, P. R. China

    Resveratrol, Health and Longevity (2009) Global Health Awareness Month Seminar Series, Philadelphia College of Osteopathic Medicine, Philadelphia, PA

    Medical education in the United States of America (2008) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

    Establishing, testing and modifying research hypothesis (2008) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

    Medical education in the United States of America (2008) Changsha Medical College, Hunan Province, PRC

    Molecular biological methodology in studying transcriptional regulation (2007) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

    Hormone receptor-targeted cancer therapy (2006) Department of Pharmaceutical Sciences, Pharmacology & Toxicology, University of the Sciences in Philadelphia, Philadelphia, PA

  • Grants

    Resveratrol, Aging and Prostate Cancer. $5000 (2006); The Center for Chronic Disorders of Aging (CCDA), Philadelphia College of Osteopathic Medicine

    Effects of Resveratrol in Aging and Prostate Cancer, $15,859; 01/01/2007-21/31/2010, 2006 Formula Grant, Pennsylvania Department of Health, Bureau of Health Statistics and Research

    Chromosomal Translocation-Induced Overexpression of ERG and Prostate Tumorigenesis, $15,000; 07/2008-06/2010, Christian R. Mary F. Lindback Foundation

    Modification of Resveratrol and Identification of More Potent Prostate Cancer Prevention Reagents: $300,000; 6/1/2010-5/31/2013 SynStar Inc.