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Srujana Rayalam, BVSc, MVSc, PhD

Srujana Rayalam, BVSc, MVSc, PhD

Assistant Professor in Pharmaceutical Sciences

Contact
Ph: 678-407-7344
FX: 678-407-7347
E-mail: srujanara@pcom.edu

Education

BVSc&AH (DVM equivalent): S.V.Veterinary University, A.P, India
Master’s in Veterinary Science: S.V.Veterinary University, A.P, India
PhD (Pharmacology): University of Georgia, Athens, GA

Narrative

Dr. Rayalam primarily teaches physiology and pathophysiology to first-year PharmD students and is also involved in teaching pharmacology, microbiology and toxicology to second- and third-year PharmD students.

Dr. Rayalam has worked in the areas of obesity, body weight regulation, phytochemicals and adipocyte biochemistry for over 7 years. Her research interests include: 1) to study the adipocyte life cycle and to understand the interaction of adipocytes with other cell types as an approach to address several problems associated with obesity; 2) to develop novel treatment strategies for obesity by inducing transdifferentiation of white to beige adipocytes and to inhibit lipid accumulation in white adipocytes; and 3) to identify combinations of phytochemicals and vitamins that have synergistic anti-adipogenic effects with an ultimate goal of developing pharmaceuticals or nutraceuticals for prevention and treatment of obesity and associated disorders. Aging is accompanied by an accumulation of adipocytes in bone marrow and Dr. Rayalam's other interest is to understand the fat-bone interaction and to identify molecular targets for the prevention of weight gain and bone loss associated with aging. Dr. Rayalam collaborates with UGA to develop novel therapies for obesity and osteoporosis.

Honors/Awards

Virbac Animal Health - Soloxine Award 2005 for achievement in excellence of endocrinology

Morris Animal Foundation Fellow in 2002

Veterinary Medical Experiment Station Assistantship in 2002-‘03

Indian Association of Lady Veterinarians-Chapter Book Prize in 2001

Selected Publications

Emma M. Laing, Ralph A. Tripp, Norman K. Pollock, Clifton A. Baile, Mary Anne Della-Fera, Srujana Rayalam, Stephen M. Tompkins, Deborah A. Keys, and Richard D. Lewis. Adenovirus 36, Adiposity and Bone Strength in Late-Adolescent Females. J Bone Miner Res. 2013 Mar;28(3):489-96.

Rayalam S, Della-Fera MA, Kasser T, Warren W, Baile CA. Emerging role of apelin as a target in cancer therapy: A patent review. Recent Pat Anticancer Drug Discov. 2011 Sep;6(3):367-72.

C. Y. Lai, J. Y. Yang, S. Rayalam, M. A. Della-Fera, S. Ambati, R. D. Lewis, M. W. Hamrick, D. L. Hartzell and C. A. Baile. Preventing Bone Loss and Weight Gain with Combinations of Vitamin D and Phytochemicals. J Med Food. 2011 Nov;14(11):1352-62

S.M. Bartell, S. Rayalam, S. Ambati, D.R. Gaddam, D.L. Hartzell, M. Hamrick, J. She, M.A. Della-Fera, C.A. Baile. Central and peripheral leptin treatment produced similar increases in muscle and bone mass in ob/ob mice. J Bone Miner Res. 2011 Aug;26(8):1710-20.

Srujana Rayalam, MaryAnne Dellafera, Clifton Baile. Synergism between resveratrol and other phytochemicals: implications for obesity and osteoporosis. Mol Nutr Food Res. 2011 Aug;55(8):1177-85.

Rayalam S, Yang JY, Della-Fera MA and Baile CA. Novel molecular targets for obesity and osteoporosis. J Nutr Biochem. 2011 Dec;22(12):1099-104.

Baile CA, Yang JY, Rayalam S, Hartzell DL, Lai CY, Andersen C and Della-Fera MA. Effect of Resveratrol on Fat Mobilization, Ann N Y Acad Sci. 2011 Jan;1215:40-7.

Andersen C, Rayalam S, Della-Fera MA and Baile CA. Phytochemicals and adipogenesis. Biofactors. 2010 Nov-Dec;36(6):415-22.

Ambati S, Li Q, Rayalam S, Hartzell DL, Della-Fera MA, Hamrick M, Baile C. Central ghrelin vs. leptin: roles in energy and bone metabolism - Endocrine. 2010 Feb;37(1):115-23.

Yang JY, Rayalam S, Della-Fera M.A, Ambati S, Baile CA. Octanoate and Decanoate Induce Apoptosis in 3T3-L1 Adipocytes. J Med Food. 2009 Oct;12(5):959-66.

Yang JY, Della-Fera MA, Rayalam S, Park HJ, Ambati S, Hausman DB, Hartzell DL, Baile CA. Regulation of adipogenesis by medium-chain fatty acids in the absence of hormonal cocktail. J Nutr Biochem. 2009 Jul;20(7):537-43.

Rayalam S, Della-Fera MA, Yang JY, Baile CA. Molecular Mechanisms of apoptosis and adipogenesis induced by Xanthuhumol and Guggulsterone in 3T3-L1 adipocytes. J Med Food. 2009 Aug;12(4):846-53.

Ambati S, Yang JY, Rayalam S, Park HJ, Della-Ferra MA and Baile CA. Ajoene exerts more potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis. Phytother Res. 2009 Apr;23(4):513-8.

Rayalam S, Della-Ferra MA and Baile CA. Phytochemicals and Regulation of Adipocyte Life Cycle. J Nutr Biochem. 2008 Nov;19(11):717-26. Epub 2008 May 20. Review.

Rayalam S, Yang JY, Ambati S, Della-Fera MA, Baile CA. Resveratrol inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Phytother Res. 2008 Oct;22(10):1367-71.

Rayalam S, Della-Fera MA, Krieg PA, Cox CM, Robins A, Baile CA. A putative role for apelin in the etiology of obesity. Biochem Biophys Res Commun. 2008 Apr 11;368(3):815-9. Epub 2008 Feb 12.

Park HJ, Rayalam S, Della-Fera MA, Ambati S, Baile CA. Withaferin A induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Biofactors. 2008;33(2):137-48.

Rayalam S, Della-Fera M.A, Ambati S, Yang JY, Park HJ, Baile CA. Enhanced Effects of 1,25(OH)2D3 Plus Genistein on Adipogenesis and Apoptosis in 3T3-L1 Adipocytes. Obesity (Silver Spring). 2008 Mar;16(3):539-46.

Rayalam S, Della-Fera M.A, Yang JY, Park HJ, Ambati S, Baile CA. Resveratrol potentiates genistein's anti-adipogenic and pro-apoptotic effects in 3T3-L1 adipocytes. J Nutr. 2007 Dec;137(12):2668-73.

Rayalam S, Della-Fera MA, Ambati S, Baile CA. Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007 Dec 21;364(3):450-6.

Selected Presentations

Srujana Rayalam, Jeong Yeh Yan, MaryAnne DellaFera, Clifton Baile; Osteogenic and anti-adipogenic effects of guggulsterone in human mesenchymal stem cells; The Obesity Society Annual Meeting, Atlanta, Nov 11 – 16, 2013.

Novel molecular targets for prevention and treatment of obesity and osteoporosis, 5th International Congress on Nutrition and Cancer, Sep 9-11, 2012, Elazig, Turkey

Emily England, Colette N Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzell, MaryAnne Della-Fera, Srujana Rayalam, Richard B. Meagher, Clifton Baile; Genistein enhances expression of genes associated with memory and eating behaviors in the ventral hippocampus of ovariectomized rats; The Obesity Society Annual Meeting, Atlanta, Nov 11 – 16, 2013.

Colette Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzell, Mary Anne Della-Fera, Srujana Rayalam, Clifton Baile; High doses of phytochemicals increase brown adipose activity in ovariectomized rats; ENDO 2013, The Endocrine Society’s 95th annual meeting, San Francisco, CA – June 15-18

Colette N. Miller, Paula T. Cooney, Srujana Rayalam, Lynda M. Brown, Clifton A. Baile. Gender differences in hepatic lipogenic and inflammatory gene expression after 72 hours of high fat diet. Experimental Biology April 20-24, 2013, Boston, MA.

Emma M. Laing, Ralph A. Tripp, Norman K. Pollock, Clifton A. Baile, Mary Anne Della-Fera, Srujana Rayalam, Stephen M. Tompkins, Deborah A. Keys, and Richard D. Lewis. Adenovirus 36, Adiposity and Bone Strength in Late-Adolescent Females, ASBMR 2012 Annual Meeting, Minneapolis, Minnesota, October 2012.

Clifton A. Baile, Jeong-Yeh Yang, Srujana Rayalam, Diane L. Hartzell, Ching-Yi Lai, Charlotte Andersen and Mary Anne Della-Fera, Effect of Resveratrol on Fat Mobilization, 1st international conference of resveratrol and health, Copenhagen, Denmark, September 13-16, 2010.

Ching-Yi Lai, Suresh Ambati, Mary Anne Della-Fera, Mark W. Hamrick, Srujana Rayalam, Marissa A. Wolfe, Jeong-Yeh Yang, Diane L. Hartzell, Rick Lewis, Clifton A. Baile. Preventing bone loss & weight gain with combinations of Vitamin D and phytochemicals. Experimental Biology April 24-28, 2010, Anaheim, CA.

Clifton A Baile, Shoshana M Bartell, Dhanunjaya R Gaddam, Suresh Ambati, Srujana Rayalam, Diane L Hartzell, Mark Hamrick, Jin-Xiong She, Mary Anne Della-Fera, Central leptin treatment mediation of bone marrow cell differentiation is enhanced when caloric restriction is imposed upon male mice. “Neuroscience” conference, Washington D.C, 2008.

Shoshana M Bartell, Dhanunjaya R Gaddam, Suresh Ambati, Srujana Rayalam, Diane L Hartzell, Mark Hamrick, Jin-Xiong She, Mary Anne Della-Fera, Clifton A Baile. Central and peripheral leptin treatment produce similar inducement of IGF-1 mediation of cortical and trabecular bone and muscle growth in ob/ob mice. “Neuroscience” conference, Washington D.C, 2008.

S. Rayalam, M.A. Della-Fera, H.J. Park, J.Y. Yang, S. Ambati and C.A. Baile. Enhanced Effects Of Genistein+Quercetin On Inducing Apoptosis And Inhibiting Adipogenesis In 3T3-L1 Adipocytes. The Endocrine Society’s 90th Annual Meeting, San Francisco, California June 15-18, 2008.

Q. Li, S. Rayalam, S. Ambati, D. Hartzell, M. A. Della-Fera, M. W. Hamrick and C. A. Baile. CNS Ghrelin and leptin have opposing functions for the regulation of food intake and bone formation in rats. FASEB J. 2007 21:581.1.

S. Rayalam, J-Y. Yang, M.A. Della-Fera, H.J. Park, S. Ambati and C.A. Baile. Resveratrol Inhibits Adipogenesis and Induces Apoptosis in 3T3-L1 Adipocytes. FASEB J. 2007; 21:550.32.

S. Rayalam, M.A. Della-Fera, S. Ambati, J.Y. Yang, H.J. Park, C.A. Baile. Synergy Between 1,25(OH)2D3 and Genistein: A Novel Approach for the Treatment of Obesity and Osteoporosis. Poster presentation at an ASBMR sponsored meeting “Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders” Arlington, Virginia, December 4-5, 2006.

Book Chapters

Srujana Rayalam, Margarethe Hoenig, and Duncan Ferguson. “Hypothalamic and Pituitary Hormones” In Veterinary Pharmacology and Therapeutics By Jim E. Riviere, Mark G. Papich 9th Edition, ISBN 0813820618, 9780813820613 Published by John Wiley and Sons, 2009:693-716.

Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati and Clifton A. Baile. “Is leptin a pro or anti-apoptotic agent” In Gertler A (ed) Leptin and leptin antagonists. ISBN: 978-1-58706-320-6.

Baile, CA, Della-Fera MA, Yang JY and Rayalam S. “Myostatin: Physiology and Applications” In Wilson G. Pond and Alan W. Bell (ed) Encyclopedia of Animal Science. ISBN 0824754964, 9780824754969.

Srujana Rayalam and Clifton A. Baile. Adipose Tissue Growth and Factors Influencing Adipocyte Life Cycle, In Michael Symonds (ed) Adipose Tissue Biology. ISBN 978-1-4614-0964-9.

Clifton A. Baile, MaryAnne Dell-Fera, Srujana Rayalam, Diane Hartzell. "Basis for Resveratrol’s Potential for Prevention and Treatment of Obesity and Osteoporosis", In ‘Health Benefits of Resveratrol against Metabolic Disorders’, ISBN: 978-1-62257-072-0 (eBook).

Srujana Rayalam, MaryAnne Della-Fera, Clifton A. Baile, “Anti-inflammatory phytochemicals, obesity and diabetes: an overview” In ‘Chronic Inflammation: Nutritional and Therapeutic Intervention’. ISBN: 978-1-4398-7211-6.

Patents

Xanthohumol Compositions and Methods of Using Same. Inventors: Clifton A. Baile, Mary Anne Della-Fera, Hea Jin Park, Jeong-Yeh Yang, Srujana Rayalam, USPTO Application #:20090075957 - Class: 514171 (USPTO)

Compositions and methods of the treatment of obesity and osteoporosis; Inventors: Mary Anne Della-Fera,Srujana Rayalam, Clifton A. Baile, USPTO Application #:20100093678 - Class: 514167 (USPTO)

 

Last Updated: 4/16/15