Michael J. Lee, PhD
Assistant Dean for Professional and Student Affairs
Assistant Professor of Pharmaceutical Sciences
PhD, Neuroscience, University of Colorado Health Sciences Center, 2004
BS, Biochemistry, University of New Hampshire, 1992
Dr. Lee is originally from New Hampshire and earned a BS degree in biochemistry from
the University of New Hampshire and a PhD degree in Neuroscience at the University
of Colorado Health Sciences Center (UCHSC) in Denver, CO. Prior to earning his Ph.D.
he was employed Xenometrix, Inc., in Boulder, CO, a biotechnology start-up company,
developing cell- and gene expression-based toxicity assays. Dr. Lee completed a post-doctoral
training fellowship at UCHSC School of Pharmacy utilizing genetically selected inbred
mice to identify candidate genes underlying rapid behavioral tolerance to alcohol.
Dr. Lee completed post-doctoral work at the Institute for Behavioral Genetics (IBG)
at the University of Colorado in Boulder, CO studying complex behavioral traits related
to drugs of abuse utilizing nicotinic receptor knock-out animals. Dr. Lee has published
peer-reviewed research articles in the areas of molecular toxicology, pharmacology,
behavioral genetics and schizophrenia.
Prior to coming to PCOM in 2011, Dr. Lee held a faculty appointment in the Department
of Pharmaceutical Sciences at the Appalachian College of Pharmacy (ACP), in Oakwood,
VA. He taught in several courses including cell biology, biochemistry, pharmacology
and immunology. In addition to his faculty appointment, he served 2 years as Assistant
Dean of Student and Alumni Affairs at ACP overseeing admissions, academic support
services, and career and professional development of pharmacy students.
Araud T, Graw S, Berger R, Lee M, Neveu E, Bertrand D, Leonard S. The chimeric gene CHRFAM7A, a partial duplication
of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochemical Pharmacology, 82(8): 904-914, 2011.
Sinkus ML*, Lee MJ*, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base
pair Deletion Polymorphism in the Partial Duplication of the Alpha7 Nicotinic Acetylcholine
Gene (CHRFAM7A) on Chromosome 15q14 is Associated with Schizophrenia. Brain Research. 1291:1-11, 2009.
* indicates authors contributed equally to manuscript.
Radcliffe RA, Floyd KL, and Lee MJ. Rapid Ethanol Tolerance Mediated by Adaptations in Acute Tolerance in Inbred Mouse
Strains. Pharmacology, Biochemistry and Behavior, 84(3): 524-534, 2006
Radcliffe, RA, Lee MJ and Williams RW. Prediction of cis-QTLs in a Pair of Inbred Mouse Strains with the
Use of Expression and Haplotype Data from Public Databases. Mammalian Genome. 17(6):629-642, 2006
Lee MJ, Breese CR, Strook, ML, Leonard S. The Effect of Nicotine and Haloperidol Co-treatment
on Nicotinic Receptor Levels in the Rat Brain. Brain Research. Molecular Brain Research. 86(1-2): 115-24, 2001.
Breese CR, Lee MJ, Adams CE, Sullivan B, Logel J, Marks MJ, Collins AC, Leonard S. Abnormal Regulation
of High Affinity Nicotinic Receptors in Subjects with Schizophrenia. Neuropsychopharmacology. 23(4): 351-64, 2000.
Lee MJ, Zolman, KL, Lintz, LC, Radcliffe, RA. Microarray Analysis of Transcription Factor
Activation Patterns in Inbred Long and Short Sleep Mice During Acquisition of Rapid
Tolerance to Ethanol. National Institute on Alcohol Abuse and Alcoholism NIAAA Trainee Workshop, Indianapolis
Alcohol Research Center, Indianapolis, IN, 2005