Dr. Bhave feels that the effectiveness of the material taught determines the success of a teacher. Her efforts as a teacher are directed towards making the subject matter interesting and relevant to the students. She hopes that the students can apply what they learn here for the betterment for their careers. Her primary teaching interests lie in the areas of pharmacology and toxicology.
Additionally, Dr. Bhave also has an active research program that offers hand on research training experience to PharmD students.
Research in Dr. Bhave’s lab focuses on investigating the mechanisms of liver regeneration
Project 1: Investigating the role of reprogramming factors (specifically OCT4), in transdifferentiation of hepatocytes to biliary epithelial cells. Clinical relevance is to find new therapeutic targets for chronic biliary liver diseases.
Project 2: Investigate the role of protease and phospholipase inhibitors in treatment of drug-induced acute liver failure.
1. American Association of Colleges of Pharmacy New Investigator Award
Funding period: 01/2015- 12/2015
Grant Title: Transdifferentiation: A New Approach for Biliary Diseases
Award amount: $10,000
2. Center for Chronic Diseases of Aging (CCDA) grant
Funding period: 07/2014- 06/2015
Grant Title: Role of FXR- signaling in hepatocyte to biliary transdifferentiation.
Award amount: $9,300
3. PCOM CSO funding
Funding period: 07/2013- 06/2014
Grant Title: Role of reprogramming factors in hepatocyte to biliary transdifferentiation.
Award amount: $13,000
4. PCOM CSO funding
Funding period: 05/2014- 04/2016
Grant Title: Role of synthetic analogue (SP) and declustering agent (noscapinoid) in treatment of liver cancer
Award amount: $9,500
1. Center for Chronic Diseases of Aging (CCDA) grant
Funding period: 07/2013- 06/2014
Grant Title: Role of reprogramming factors in transdifferentiation of hepatocytes to biliary epithelial cells.
Award amount: $15,600
2. University of Pittsburgh, Department of Pathology Post-doctoral Research Training
Funding period: 07/2012 – 06/2013
Grant Title: Role of stem cell/reprogramming factors in transdifferentiation of hepatocytes to biliary epithelial cells.
Award amount: $10,000
3. Society of Toxicology Colgate Palmolive Student Research Training Grant In alternative
Methods in Toxicology
Funding period: 03/2005-02/2006
Grant Title: Role of Calpastatin in resisting calpain-induced injury in hepatocytes.
Award amount: $3,500
2015: ad-hoc reviewer (ECR) for HBPP study section of CSR, NIH, June 22-23, Washington
2015: PCOM Research Day student poster, first place. Reprogramming factor Oct4 is crucial for transdifferentiation of hepatocytes to biliary epithelial cells. Mboya Doffou*, George Adams*, Anne Sprain, George Michalopoulos, and Vishakha Bhave.
2014: American Association of Colleges of Pharmacy, New Investigator Award
2014: Session chair, “Hepatic Regenerative Medicine: Coping with Injury Via Survival, Proliferation and Stem Cells.” Tuesday April 29, Experimental Biology 2014, San Diego, CA
2013: Publication (PMID: 23665349) featured in ‘Hot off the Press’ section of American Society of Investigative Pathology (ASIP) newsletter.
2007: Society of Toxicology Mechanisms Specialty Section Carl Smith Graduate student Award for meritorious research.
2007: Society of Toxicology, Merck Graduate Travel support.
2006: Society of Toxicology In Vitro Specialty Section student award, honorable mention.
2006: American College of Toxicology travel award
2005: Society of Toxicology Colgate Palmolive Student Research Training Award in Alternative Methods in Toxicology
2000: Sir Ratan Tata merit scholarship for undergraduate studies in Pharmacy
1. Liver Regenrtion: Chapter 18, Hepatocyte to Biliary transdifferentiation: To be(come)
or not to be(come)? Vishakha Bhave, Elsevier publications, in press, 2015.
2. Donthamsetty S, Bhave V. S., Mars W., Orr A., Haynes M. M., Wu C., and Michalopoulos G. K. Role of PINCH-Rsu-1 Complex in Regulating Liver size and tumorigenesis, PLOS One, 8(9):e74625, 2013.
3. Bhave V. S.,, Donthamsetty S., Zhang X., Tan L., Lou J., Bowen B.W., Michalopoulos G.K. Regulation of liver growth by Glypican 3, CD81, Hedgehog, and Hhex. Am J Pathol, 183: 153-159, 2013. This publication (PMID: 23665349) is selected to be featured in ‘Hot off the Press’ section of American Society of Investigative Pathology (ASIP) newsletter, November 2013 issue.
4. Bhave V. S., Shirish Paranjpe, William C. Bowen, Shashikiran Donthamsetty, Aaron W. Bell, Jaspal S. Khillan, and George K. Michalopoulos. Genes Inducing iPS Phenotype Play a Role in Hepatocyte Survival and Proliferation in vitro and Liver Regeneration in vivo. Hepatology, 54(4):1360-1370, 2011.
5. Bhave, V. S., Donthamsetty, S., Latendresse, J. R., Cunningham, M., and Mehendale. H. M. Absence of hepatic COX-2 exacerbates sPLA2-mediated progression of hepatotoxicity initiated by acetaminophen. Toxicol. Appl. Pharmacol. 251: 173-180, 2011.
6. Donthamsetty S, Bhave V. S, Kliment CS, Bowen WC, Mars WM, Bell AW, OrrA, Wu C and Michalopoulos GK Excessive Hepatomegaly of Mice with Hepatocyte-Targeted Elimination of Integrin Linked Kinase Following Treatment by TCPOBOP. Hepatology, 53(2):587-95, 2011.
7. Chih Wen Lin, Wendy M. Mars Shirish Paranjpe, Shashikiran Donthamsetty, Bhave V. S., Liang I Kang, Anne Orr, William C. Bowen, Aaron W. Bell and George K. Michalopoulos. Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology, 54(2):620-30, 2011.
8. Donthamsetty S, Bowen WC, Mars WM, Luo JH, Orr A, Bhave V. S., Wu C, Michalopoulos GK. Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged cell proliferation and hepatomegaly after Phenobarbital Administration. Toxicological Sciences, 113(2):358-366, 2010.
9. Bhave, V. S., Donthamsetty S., Latendresse J. R., Muskhelishvili L, and Mehendale H. M. Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient COX-2. Toxicol. Appl. Pharmacol., 228(2):225-38, 2008.
10. Bhave, V. S., Donthamsetty S., Latendresse J. R., and Mehendale H. M. Inhibition of COX-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury. Toxicol. Appl. Pharmacol., 228(2):239-46, 2008.
11. Donthamsetty, S., Bhave, V. S., Mitra, M. S., Latendresse, J. R., and Mehendale HM. Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPAR alpha with clofibrate. Toxicol. Appl. Pharmacol., 230(3):327-37, 2008.
12. Donthamsetty, S., Bhave, V. S., Mitra M. S., Latendresse, J. R., and Mehendale, H. M. Non alcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology, 45(2):391-403, 2007.
13. Limaye P. B., Bhave V. S., Palkar P. S., Apte U. M., Sawant S. P., Yu S., Latendresse J. R., Reddy J. K., and Mehendale H. M. Upregulation of calpastatin in regenerating and developing livers: Role in resistance against hepatotoxicity. Hepatology, 44(2):379-388, 2006.
Dr. Bhave serves as an ad-hoc reviewer for the following: