Core Research Focus

There are four key areas of research focus at PCOM:

illustration of the human heart

Cardiovascular Functions and Disease

Researchers focus on cardiovascular disease, development and prevention in projects encompassing:

  • Novel aspects of reperfusion injury following myocardial ischemia
  • Effects of sex steroids on cardiovascular function
  • Sudden cardiac death caused by lethal arrhythmias
  • Development and regulatory systems of cardiac muscle and vasculature
  • Key mechanisms involved in myocardial infarction, stroke and diabetes


illustration of DNA

Molecular Basis of Disease

Researchers in this group focus on molecular mechanisms of cancer, cell biology, and inflammation and methods to treat and prevent the consequences of abnormal cell/tissue influence in the following ways:

  • Homeostatic regulation of gene expression, particularly in response to inflammation.
  • Role of omega-3 fatty acids in diminishing chronic inflammation
  • Nutrient control of gene expression in health and disease
  • Androgen receptor function in prostate cancer


illustration of the human skeleton


Researchers are focused on identifying, understanding and developing ways to treat and prevent bone, joint, muscle disease and dysfunction as follows:

  • Counteracting bone and tissue damage in rheumatoid arthritis
  • Anti-infective technologies in joint prostheses
  • Mechanisms that regulate the formation and remodeling of cartilage and bone
  • Novel approach to stop the destruction of joint tissue in osteoarthritis
  • Vertebrate form and function
  • 2-dimensional morphometrics to measure the effect of OMT on spinal curvatures


illustration of the neuron

Neuroscience and Neurodegenerative Disorders

Researchers are focused on brain, spinal cord, and neuromuscular dysfunction, disease and health, including dementia, brain and spinal cord injury, neurodegenerative diseases, and muscular dystrophy in the following ways:

  • The infectious agent paradigm in Alzheimer’s disease
  • Cell biology of neurons; receptors in the prefrontal cortex
  • Neurotoxicity of metals and of methamphetamine
  • Cerebellar function, using optogenetic methods
  • Potential pathological pathways in spinal and bulbar muscular atrophy
  • Nerve regenerative process in spinal cord, nerve injuries and neurological diseases