Grants

A major initiative of the CCDA is to aid in the development of new studies either by providing pilot grants to investigators studying chronic diseases/disorders in the aging process or creating collaboration between CCDA members.

The goals of this initiative are to:

  1. increase research within the CCDA and Colleges of Osteopathic Medicine;
  2. increase scholarly activity within the PCOM community;
  3. establish preliminary studies for large grant applications to organizations such as the NIH and NSF; and
  4. provide recognition of the existence of the CCDA as a unique entity supporting basic and applied research into healthy aging and major chronic problems of the 21st century.

Major granting agencies include the National Institues of Health and the National Science Foundation.

 

Pilot Research Grants

2017 - 2018

  • Cathy J. Hatcher, PhD - Associate Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Contributions of a Novel Cardiac Protein to Coronary Vessel Formation”
  • Jocelyn Lippman-Bell, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Characterization and pharmacological targeting of the chronic behavioral consequences of early-life seizures in zebrafish”
  • Heather L. Montie, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – "Generation and characterization of a zebrafish model of SBMA"
  • Lindon Young, PhD - Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “The effects of PKC epsilon activator/inhibitor peptides on nitric oxide release and hypoxia/re-oxygenation induced cell death in human umbilical vein endothelial cells”

2016 - 2017

  • Cathy J. Hatcher, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Ajap 1 in Congenital Defects of Coronary Vessel Formation”
  • Abigail Hielscher, PhD - Assistant Professor of Bio-Medical Sciences, Georgia Campus – PCOM – “Loss of stromal caveolin-1 on chemotherapy responses of breast tumor cells”
  • Jocelyn Lippman-Bell, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Investigating dendritic spine plasticity after seizures”
  • Heather L. Montie, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Does activation of AMPK abrogate SBMA pathogenesis?”
  • Mary P. Owen, JD, PhD - Professor of Bio-Medical Sciences, Georgia Campus – PCOM – “Novel Mechanism Involved in Rapid Testosterone-Induced Vasodilation of Myogenic Tone in Mesenteric Resistance Microvessels”
  • Srujana Rayalam, PhD - Assistant Professor of Pharmaceutical Sciences, Georgia Campus – PCOM - “Synergistic effects of phytochemicals and immunomodulatory glycan LNFPIII on the beiging of adipocytes: a novel therapeutic approach for obesity”
  • Dianzheng Zhang, PhD - Associate Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “The mechanism of HP1γ-mediated prostate cancer progression through regulating de novo fatty acid synthesis”

2015 - 2016

No Pilot grants were awarded this year.

2014 - 2015

  • Sarah Allen, PhD – Assistant Professor of Psychology, Philadelphia Campus – PCOM –
    “Executive Functioning and Frontal Lobe Activity in Pediatrics with Concussion: A Functional Near-Infared Spectroscopy (fNIR) Investigation”
  • Vishakha Bhave, PhD - Assistant Professor of Pharmaceutical Sciences, Georgia Campus – PCOM - “Role of bile acid-FXR signaling in hepatocyte to biliary transdifferentiation”
  • Cathy Hatcher, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “A Transgenic Mouse Model of Ischemic Cardiomyopathy”
  • Abigail Hielscher, PhD - Assistant Professor of Bio-Medical Sciences, Georgia Campus – PCOM - “The role of matrix rigidity on morphological and functional characteristics of human mammary fibroblasts grown in 3D gelatin hydrogels”
  • Huo Lu, PhD - Assistant Professor of Bio-Medical Sciences, Georgia Campus – PCOM - “Study Cerebellar Nuclei Output to Thalamus Using Autopatch Recording”
  • Heather Montie, PhD - Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Determining the role of SIRT3 in spinal and bulbar muscular atrophy”
  • Mei Xu, PhD - Associate Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Molecular manipulation to promote axon regeneration”

2013 - 2014

  • Christopher Adams, Ph.D., Associate Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Bactericidal Implant Surfaces”
  • Vishakha Bhave, Ph.D., Assistant Professor of Pharmaceutical Sciences, Georgia Campus - PCOM – “Role of programming factors in trans-differentiation of hepatocytes to biliary epithelial cells”
  • Qian Chen, Ph.D., Research Assistant Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM - “The role of mitochondria in acute hyperglycemia: activation of vascular NADPH oxidase and eNOS uncoupling”
  • Marina D’Angelo, Ph.D., Professor of Bio-Medical Sciences, Philadelphia Campus – PCOM – “Development of an in vitro, whole tooth model to study effects of endogenous matrix metalloprotease activity on resin restorations”
    Xinyu Wang Ph.D., Assistant Professor of Pharmaceutical Sciences, Georgia Campus - PCOM – “Inhibitory effects of caffeic acid phenethyl ester (CAPE) on multiple myeloma cell growth: Nrf2 and NF-kB crosstalk”
  • Richard White, Ph.D., Professor of Basic Science, Georgia Campus – PCOM – “Mechanisms of androgen regulation of the microvasculature”

2012 - 2013

  • Christopher Adams, Ph.D., Associate Professor of Anatomy, Philadelphia Campus – PCOM
    “The mechanism by which osteoblast maturation regulates calcium and phosphate ion pair-induced apoptosis”
  • Brian J. Balin, Ph.D., Professor of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus - PCOM
    “Detection of Chlamydia pneumoniae in blood samples: A diagnostic screen for Alzheimer's disease”
  • Marcus Bell, Ph.D., Associate Professor of Neuroscience, Physiology, Pharmacology, Philadelphia Campus – PCOM
    “Infection with Chlamydia pneumoniae alters calcium-associated gene regulations and processes in neuronal cells and monocytes: Implications for Alzheimer’s disease”

    Qian Chen, Ph.D., Research Assistant Professor of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus - PCOM
    “Role of acute hyperglycemia in myocardial ischemia/reperfusion”
  • Marina D’Angelo, Ph.D., Professor of Anatomy, Philadelphia Campus - PCOM
    “Assaying endogenous matrix metalloproteases (MMPs) in acid-etched, dentinal cavity walls of an extracted tooth “
  • Mandana Ghodrat, PharmD., Assistant Professor of Pharmacy Practice, Georgia Campus - PCOM
    “Role of cathepsins D and L as novel markers in acute coronary syndrome in females”
  • Lori Hardy, Ph.D., Associate Professor of Basic Science - Georgia Campus – PCOM
    “CaMKIIb regulation of the actin cytoskeleton”
  • Ramadevi Nimmanapalli, D. Phil., Dipl. ACVM - Associate Professor of Pharmaceutical Sciences, Georgia Campus - PCOM
    “Development of heat shock protein 70 inhibitory antibodies”
  • Srujana Rayalam, Ph.D. - Assistant Professor of Pharmaceutical Sciences, Georgia Campus - PCOM
    “Vitamin D and phytochemicals for prevention of obesity and osteoporosis”
  • Desuo Wang, Ph.D. - Assistant Professor of Pharmaceutical Sciences, Georgia Campus – PCOM
    “Angiotensin II and glutamate additively or synergistically disrupt the intracellular Ca2+ homeostasis of astroglia”
  • Xinyu (Eric) Wang, Ph.D. - Assistant Professor of Pharmaceutical Sciences, Georgia Campus - PCOM
    “Inhibitory effects of caffeic acid phenethyl ester (CAPE) on multiple myeloma cell growth”
  • Mei Xu, M.D., Ph.D., Assistant Professor of Anatomy, Philadelphia Campus – PCOM
    “A functional role of IMP2 in axon regeneration in localizing specific MRNAs”

2011 - 2012

  • Christopher Adams, Ph.D., Associate Professor of Anatomy, Philadelphia Campus – PCOM
    “The role of osteoblast maturation in the regulation of calcium and phosphate ion pair-induced apoptosis”
  • Denah M. Appelt, Ph.D., Professor of Neuroscience, Pharmacology & Physiology, Philadelphia Campus – PCOM
    “Analysis of autophagy and apoptosis gene regulation in neuronal cells infected with Chlamydia pneumoniae”
  • Stacy Cahn, Ph.D., Assistant Professor of Psychology, Philadelphia Campus – PCOM
    “Predictors of successful weight loss following bariatric surgery”
  • Qian Chen, Ph.D., Research Assistant Professor of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus- PCOM
    “The role of NADPH oxidase and eNOS in acute hyperglycemia-incuded oxidative stress conditions”
  • Marina D’Angelo, Ph.D., Associate Professor of Anatomy, Philadelphia Campus- PCOM
    “Effect of BodyJet and VASER liposuction technique on the validity and differentiation of adipose derived stem cells “
  • Yueqiao (George) Huang - Assistant Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Protein synthesis-dependent NMDA receptor trafficking after dopamine D-1 receptor activation”
  • Frank Jenney, Ph.D., Assistant Professor of Biochemistry - Georgia Campus – PCOM
    “Amelioration of ischemia/reperfusion injury with an anaerobic enzyme, superoxide reductase”
  • John Kermode, Ph.D. - Professor of Pharmaceutical Science, Georgia Campus – PCOM
    “Meta-analysis of platelet receptor polymorphisms as risk factors for myocardial infarction and stroke”
  • Michael Kuchera, D.O., Professor of OMM, Philadelphia Campus – PCOM
    “Exploring the use of intensive osteopathic lymphatic drainage treatment for loew extremity lymphedema in the elderly”
  • Ramadevi Nimmanapalli, D. Phil., Dipl. ACVM - Associate Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Role of HSP70 in myeloma stromal cell interaction”
  • Eric Wang, Ph.D. - Assistant Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Identification of potential drug candidates for ameliorating oxidative stress involved ischemia reperfusion injury”
  • James Wu, Ph.D., Assistant Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “The design and synthesis of amino acid or peptide prodrugs to improve delivery and targeting of anticancer agents”
  • Mei Xu, M.D., Ph.D., Assistant Professor of Anatomy, Philadelphia Campus – PCOM
    “Enhancement of axon regeneration by localizing specific MRNAs”
  • Lindon Young, Ph.D., Associate Professor of Pathology, Microbiology, Immunology & Forensic Medicine, Philadelphia Campus – PCOM
    “The effect of triascin-C on leukocyte-endothelial interactions by using intravital microscopy”

 

2010 - 2011

  • Christopher Adams, Ph.D., Associate Professor of Anatomy, Philadelphia Campus – PCOM
    “Effect of liposuction technique on the validity and differentiation of adipose derived stem cells”
  • Yun Bai, Ph.D., Assistant Professor of Pharmaceutical Science, Georgia Campus – PCOM
    “Nerve growth factors intranasal delivery to the CNS for Alzheimer’s disease treatment”
  • Brian J. Balin, Ph.D., Professor of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus- PCOM
    “The role of tryptophan metabolism in C. pneumoniae infected monocytes: Implications for Alzheimer’s disease”
  • Ruth Borghaei, Ph.D., Professor of Biochemistry and Molecular Biology, Philadelphia Campus – PCOM
    “Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells”
  • Qian Chen, Ph.D., Research Assistant Professor of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus- PCOM
    “The oxidative stress and inflammatory responses under acute hypoglycemic conditions”
  • Marina D’Angelo, Ph.D., Associate Professor of Anatomy, Philadelphia Campus- PCOM
    “Novel metalloprotease peptide derivative therapeutics for osteoarthritis“
  • Susan Hingley, Ph.D., Professor of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus- PCOM
    “Changes in expression of genes associated with Alzheimer’s disease and β-amyloid processing due to infection of neuronal cells by Chlamydia pneumoniae and/or herpes simplex virus type 1”
  • Huo Lu, Ph.D., Assistant Professor of Anatomy, Georgia Campus - PCOM
    “Optogenic study of cerebellar circuit”
  • Harish S. Parihar, R.Ph., Ph.D., Assistant Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Design and synthesis of molecular probes for serotonin type 3 receptors and nicotinic acetylcholine receptor architecture and molecular-level function”
  • Avadhesh Sharma, Pharm.D., Ph.D., Chair, Associate Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Ketamine-mediated modulation of NMDA and opioid receptors in activated platelets”
  • Desuo Wang, Ph.D., Assistant Professor of Pharmaceutical Science, Georgia Campus - PCOM
    “Dually targeting L-type Ca2+ channel and type 4 phosphodiesterase for treatment of obesity”

 

2009 - 2010

  • Adwoa Aduonum, PhD, Assistant Professor of Physiology, Georgia Campus - PCOM “Methamphetamine modulation of synaptic plasticity”
  • Brian J. Balin, PhD, Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus - PCOM “Modulation of Chlamydia pneumoniae infection of THP1 cells following exposure to pDAG"
  • Qian Chen, PhD, Research Assistant Professor, Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus - PCOM “The role of the protein kinase C beta II in acute hyperglycemia induced leukocyte-endothelial interactions by using intravital microscopy”
  • Marina D’Angelo, PhD, Associate Professor, Department of Anatomy, Philadelphia Campus - PCOM “Efficacy of collagenase 3 peptides in abrogation of tissue destruction in an animal model of osteoarthritis”
  • Kerin Fresa-Dillon, PhD, Professor,Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus – PCOM “Efficacy of a vaccine against C. pneumoniae in prevention of respiratory infection and/or respiratory spread”
  • Susan Hingley, PhD, Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus- PCOM “Investigation of mouse hepatitis virus entry into host cells using siRNA technology”
  • Harold L. Komiskey, Ph.D., Professor of Pharmacology, Georgia Campus - PCOM “Resveratrol, estrogen, and curcumin effect on manganese-induced toxicity of rat astrocytes”
  • Lindon H. Young, PhD, Associate Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus- PCOM “Tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2) in leukocyte-endothelium interactions by using intravital microscopy”

2008 -2009

  • Adwoa Aduonum, PhD, Assistant Professor of Physiology, Georgia Campus - PCOM “Methamphetamine modulation of synaptic plasticity”
  • Denah Appelt, PhD, Professor, Department of Neuroscience, Pharmacology & Physiology, Philadelphia Campus - PCOM “Chlamydophila (Chlamydia) pneumoniae (Cpn) promotes Ab 1-42 amyloid processing in neuronal cells: A pathogenic trigger for Alzheimer’s Disease”
  • Brian J. Balin, PhD, Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus - PCOM “Analysis of Chlamydia pneumoniae Infection and Alzheimer’s disease pathology in the human olfactory system”
  • Denise Burns, DO, Assistant Professor, Department of Osteopathic Manipulative Medicine, Philadelphia Campus - PCOM “The effects of osteopathic manipulation versus laser treatments on hypothyroidism”
  • Qian Chen, PhD, Research Assistant Professor, Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia Campus - PCOM “PKC isoform inhibition in leukocyte-endothelium interactions by using intravital microscopy”
  • Farzaneh Daghigh, PhD, Associate Professor, Department of Biochemistry and Molecular Biology, Philadelphia Campus - PCOM “Determination of the physiologically and pathophysiologically relevance of arginase isoforms in NO production by human gingival fibroblasts”
  • Marina D’Angelo, PhD, Associate Professor, Department of Anatomy, Philadelphia Campus - PCOM “The protease sensitive hinge region of LTBP1 is a substrate for MMP-13”
  • Randal Gregg, PhD, Assistant Professor, Dept. of Pathology, Microbiology, Immunology & Forensic Medicine, Georgia Campus - PCOM “Modeled microgravity effect upon dendritic cell activation of tumor-specific CD8+T cells and melanoma growth”
  • Francis E. Jenney, Jr, PhD, Assistant Professor, Dept. of Biochemistry, Georgia Campus - PCOM “Utilization of a small, hyperstable iron-protein, Pyrococcus furiosus rubredoxin, as a medical diagnostic and therapeutic tool”
  • Michael L. Kuchera, DO, Professor and director, OMM Research/Human Performance & Biomechanics Laboratory, Philadelphia Campus - PCOM “A multi-center pilot study to evaluate the effect of a pelvic orthotic and OMT protocol to reduce the impact of postural decompensation in L5-S1 isthmic spondylolisthesis subjects with chronic, recurrent low back pain”
  • Michael McGuinness, PhD, Associate Professor, Department of Anatomy, Philadelphia Campus - PCOM “Estrogen regulation of cell adhesion molecules and their role in Sertoli cell-spermatogenic cell interaction”
  • Mary P. Owen, PhD, JD, Associate Professor, Department of Pharmacology, Georgia Campus - PCOM “Control of retinal arteriole smooth muscle vasodilation: Exploring the role of glucose, PGI2, BKca channels, and extravascular pressure”
  • Lindon H. Young, PhD, Associate Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus - PCOM “Administration of protein kinase C beta II Inhibitor during extracorporeal shock wave lithotripsy reduces free radical production”

2007 - 2008

  • Denah Appelt, PhD, Professor, Department of Neuroscience, Pharmacology & Physiology, Philadelphia Campus - PCOM “Effects on the apoptotic markers following a Chlamydial infection in neurons and astrocytes: implications for Alzheimer’s disease”
  • Marina D’Angelo, PhD, Associate Professor, Department of Anatomy, Philadelphia Campus - PCOM “Hypertrophic chondrocytes produce a large latent TGFb complex that includes MMP13”
  • Stephanie H. Felgoise, PhD, ABPP, Associate Professor and Vice Chair, Department of Psychology, Philadelphia Campus - PCOM “Quality of life, coping, and psychological well-being in children with LQTS and their primary caregivers”
  • Katherine D. Galluzzi, DO, CMD, FACOFP, Professor and Chairperson, Department of Geriatric Medicine, Philadelphia Campus - PCOM “The physician’s role in death: utilizing SP program to bring issues to life”
  • Susan T. Hingley, PhD, Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus - PCOM “Development of a real-time PCR assay for the investigation of viral entry mechanisms”
  • C. Scott Little, PhD, Assistant Professor, Department of Pathology, Microbiology, Immunology, & Forensic Medicine, Philadelphia Campus - PCOM “Development and immune modulation of peanut allergy in BALB/c and C3H/HeJ mice”