YUN BAI, PHD
Department of Pharmaceutical Sciences
Associate Professor


Yun Bai, PhD

Contact

Email: yunba@pcom.edu
Office: 678-407-7344
Research Page

Dr. Bai been working in the field of drug delivery for many years. Her contributions to the advancement of science are best documented through publications in scientific journals. She has a total of 16 research papers in international, peer-reviewed journals, including the world-renowned scientific journal Proc Natl Acad Sci US.

Dr. Bai's first authored paper was published in the high-profile journal PNAS and also was featured in the Research Highlights section of Nature Review Drug Discovery.

Since Dr. Bai joined PCOM, she has published six manuscripts in peer-reviewed scientific journals, including first authorship and coordinating authorship.

  • Education

    PhD, Pharmaceutical Sciences, University of Southern California, 2006
    MS Biochemistry and Molecular Biology, Tsinghua University, China, 2000
    BS Pharmacy, Peking University Health Science Center, China, 1997

  • Courses

    Dr. Bai has coordinated and taught in courses Pharmaceutics, Pharmaceutics Lab, Biologics and Biopharmaceutic. She also participated in teaching courses in Biopharmaceutics, Pharmacokinetics, Physiology & Pathophysiology II.

  • Awards

    2012, Peach Teaching Award
    School of Pharmacy, Philadelphia College of Osteopathic Medicine

    2006, Outstanding Research Assistant Award
    University of Southern California, School of Pharmacy

    2005, Invited as the only student speaker
    USC-AAPS 2005 Symposium Moving Targets

    2005, Bai et al., Proc Natl Acad Sci USA. 102(20): 7292-6 was featured in the Research
    Highlights section of Nature Review Drug Discovery 4, 537 (2005).

    2005, Abstract nominated for Innovative Aspects of Oral Drug Delivery and Absorption
    Graduate/Post-doctor
    Controlled Release Society (CRS)

    2004, Graduate Student Award in the AAPS Graduate Symposium in Drug Delivery and Pharmaceutical Technologies
    American Association of Pharmaceutical Scientists (AAPS)

    2004, Second Place Award in poster section
    USC-AAPS 2004 Symposium Moving Targets

  • Publications

    Selected Publications

    Peer-Reviewed Publications

    Sachdeva V, Bai Y, Kydonieus A, Banga AK. (2013) Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies. Int J Pharm. 441(1-2):9-18.

    Yu T, Bai Y. (2013) Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic Networks. Current Metabolomics. 1(1): 84-91.

    Vemulapalli V, Bai Y, Kalluri H, Herwadkar A, Kim H, Davis SP, Friden PM, Banga AK. (2013) In vivo iontophoretic delivery of salmon calcitonin across microporated skin. J Pharm Sci. 101(8):2861-9

    Yu T#, Bai Y#. (2011) Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors. BMC Genomics. 12:563. (# joint correspondence author)

    Yu T#, Bai Y#. (2011) Capturing Changes in Gene Expression Dynamics by Gene Set Differential Coordination Analysis. Genomics. 98(6):469-77. (# joint correspondence author)

    Chen X, Bai Y, Zaro J, Shen WC. (2010) Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques. 49(1): 513-8.

    Bai Y, Shen WC. (2006) Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization. Pharm Res. 23(9):2116-21.

    Bai Y, Ann DK, Shen WC. (2005) Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proc Natl Acad Sci U S A. 102(20):7292-6.

    Widera A, Bai Y, Shen WC. (2004) The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice. Pharm Res. 21(2):278-84.

    Bai Y, Zhao Y, Yu T, Dierich MP, Chen YH. (2000) Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-alpha and IFN-beta. Int Arch Allergy Immunol. 121(2): 170-2.

    Yu T, Bai Y, Dierich MP, Chen YH. (2000) Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type-1 (HIV-1). Microbiol Immunol. 44(2): 105-10.

    Yu T, Xiao Y, Bai Y, Ru Q, Luo G, Dierich MP, Chen Y. (2000) Human interferon-beta inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41. Immunol Lett. 73(1):19-22.

    Chen YH, Bai Y, Yu T, Dierich MP. (1999) Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36. Immunol Lett. 68(2-3): 415-7.

    Chen YH, Yu T, Bai Y, Dierich MP. (1999) Immunogenicity of the GPGRAFY epitope on synthetic peptides. Immunol Lett. 69(3): 353-4.

    Chen YH, Yu T, Bai Y, Zhao N. (1999) Two proteins share immunological epitopes on the tumor-associated antigen 17-1A. Cancer Lett. 144(1): 101-5.

    Bai Y, Yu T, Zhao Y, Xiao Y, Yang Y, Chen YH. (1999) A novel putative tumor associated antigen. Tsinghua Sci. & Tech. 4(3): 1568-9.

    Work in Progress

    Bai Y, Kim H, Friden P, and Banga AK. Confocal study of transdermal delivery of albumin by microneedles and Iontophoresis. (In submission)

    Patent

    Shen WC, Bai Y, Ann DK, and Widera A. US Patent Pending No. 20090042777: G-CSF-Tranferrin Fusion Proteins.

    Selected Presentations

    Podium Presentations

    Bai Y, Banga, AK. Transmembrane Delivery of Peptides and Protein with Combination of Iontophoreis and Microporation. PepCon, Protein & Peptide Conference. Beijing, China, 2011.

    Bai Y, Shen WC. Oral Delivery of Therapeutic Proteins. AAPS-University of Southern California, Moving Targets, the 4TH Annual Multidisciplinary Scientific Symposium, Los Angeles, CA, 2005.

    Bai Y, Shen WC. Transferrin Receptor –Mediated Oral Delivery of Therapeutic Proteins: a Study of G-CSF-Transferrin Fusion Protein. AAPS Annual Meeting, Baltimore, Maryland, 2004.

  • Grants

    • Support from Center of Science Officer (CSO), 2012-2013 ($4500)
    • Intramural Research Grant, Philadelphia College of Osteopathic Medicine