SHU ZHU, MD, PHD
Department of Bio-Medical Sciences - Georgia
Assistant Professor of Neuroscience, Physiology and Pharmacology


Shu Zhu, MD, PhD

Contact

Email: shuzh@pcom.edu
Office: 678-225-7476
Research Page

My teaching experience has been in Physiology, Pathophysiology, Pharmacology and Clinical Medicine. While a faculty member in the Department of Physiology in Dalian Medical University, I taught students from different levels and different schools such as School of Basic Medicine, School of Nursing, and School of Allied Health. I was also highly involved in the development and teaching of Integrated Functional Laboratory in the medical students’ curriculum. Currently, I’m teaching in both of the DO and Biomedical Sciences programs. My teaching responsibilities mainly focus on Respiratory Physiology and Endocrine Physiology in the DO program, while I’m teaching courses such as Scientific Communication, Vascular Control Mechanisms and Historical Development Current Themes in Biomedical Science Research in the Biomedical program. I also serve as a mentor and committee member to Masters students.

  • Education

    Postdoctoral Training, Department of Pharmacology and Toxicology, Georgia Regents University, Augusta, GA, 2007-2012
    PhD, Pharmacology from Georgia Regents University, Augusta, GA, 2007
    MD, Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China, 1997

  • Research

    My research specialties are electrophysiology and molecular biology, and my research interests focus on the regulation of ion channels in cardiopulmonary diseases. Specifically, the expression and regulation of large conductance, calcium- and voltage-activated potassium (BKCa) channels by protein kinases in pulmonary arterial smooth muscle cells from pulmonary hypertensive animal model. My research work has been published in several high-reputation peer-reviewed journals such as American Journal of Physiology, Cardiovascular Research, and Journal of Pharmacology and Experimental Therapeutics.

  • Awards

    ‘Best Presentation Award among Young Faculty’ from Dalian Medical University, Dalian, Liaoning, China

    ‘Faculty and Spouse Club Scholarship Award’ from Georgia Regents University, Augusta, GA

    ‘Excellence in Research Award’ on Graduate Research Day from Georgia Regents University, Augusta, GA

  • Publications

    Selected Publications

    White RE, Han G, Maunz M, Dimitropoulou C, EI-Mowafy AM, Barlow RS, Catravas JD, Snead C, Carrier GO, Zhu S, Yu X. Endothelium-independent effect of estrogen on Ca2+-activated K+ channels in human coronary artery smooth muscle cells. Cardiovascular Research. 2002, 53: 650-661.

    Zhu S, Han G, White RE. PGE2 action in human coronary artery smooth muscle: role of potassium channels and signaling cross-talk. Journal of Vascular Research. 2002, 39: 477-488.

    Barman SA, Zhu S, Han G, White RE. cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6): L1004-L1011.

    Barman SA, Zhu S, White RE. Protein kinase C inhibits BKCa channel activity in pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1): L149-155.

    Barman SA, Zhu S, White RE. PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6): L1275-1281.

    White RE, Han G, Dimitropoulou C, Zhu S, Miyake K, Fulton D, Dave S, Barman S.A. Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscel. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4): H1468-1475.

    Barman SA, Zhu S, White RE. Hypoxia modulates cyclic AMP activation of BKCa channels in rat pulmonary arterial smooth muscle. Lung. 2005, 183:353-361.

    Han G, Yu X, Lu L, Li S, Ma H, Zhu S, Cui X, White RE. Estrogen receptor alpha mediates acute K channel stimulation in human coronary artery smooth muscle cells. J Pharmacol Exp Ther. 2006 Mar; 316(3):1025-1030.

    Zhu S, RE White, SA Barman. Effect of PKC isozyme inhibitation on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle. Lung. 2006 Mar-Apr; 184(2):89-97.

    Barman SA, Zhu S, White RE. Cyclic nucleotide and protein kinase signaling in hypertensive pulmonary arterial smooth muscle. Current Respiratory Medicine Reviews. 2006 2: 15-25.

    Barman SA, Zhu S, White RE. Protein kinase signaling in hypertensive pulmonary arterial smooth muscle (Invited review article): Current Topics in Pharmacology. 2006 10: 67-79.

    Zhu S, RE White, SA Barman. Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle. Therapeutic Advances in Respiratory Disease. 2008 Jun; 2(3): 119-127.

    Zhu S, DD Browning, RE White, DJ Fulton, SA Barman. Mutation of protein kinase C phosphorylation site S1076 on {alpha}-subunits affects BKCa channel activity in HEK293 cells. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4): L758-66.

    Barman SA, Zhu S, White RE. RhoA/Rho kinase signaling: a therapeutic target in pulmonary hypertension. Vascular Health and Risk Management. 2009 5: 663-671.

    White RE, Barman SA, Zhu S, Han G. Relationship of Oxidative Stress with Cardiovascular Disease (Book Chapter): Studies on Women's Health Series: Oxidative Stress in Applied Basic Research and Clinical Practice, Editors: Ashok Agarwal, PhD, Botros Rizk, MD, Nabil Aziz, FRCOG, MD, Cleveland Clinic. Springer - Verlag Press. 2012 May; Chapter 15.

    Barman SA, Zhu S, White RE. Protein kinase regulation of BKCa channels in pulmonary arterial smooth muscle (Book Chapter): Recent Advances in Pulmonary Vascular Biology. 2012, 163-184.

    Sonne SR, Bhalla VK, Barman SA, White RE, Zhu S, Newman TM, Prasad PD, Smith SB, Offermanns S, Ganapathy V. Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth. Biochim Biophys Acta. 2013 Apr 8; 1832(8):1149-1158.

    Zhang X, Wang H, Duvernay MT, Zhu S, Wu G. The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking. PLoS ONE. 2013, 8(2): e57805. doi:10.1371/journal.pone.0057805.

    Selected Presentations

    S. Zhu, G. Han, R.E. White. PGE2 opens BKCa channels in human coronary smooth muscle by cross-activating PKG. Experimental Biology Conference, April 2002.

    G. Han, D. Fulton, S. Zhu, C. Dimitropoulou, R.E. White. Estrogen stimulates nNOS activity in human coronary smooth muscle cells via the PI3-Akt signaling cascade. Experimental Biology Conference, April 2003.

    C. Dimitropoulou, R.E. White, S. Zhu, G. Han, J.R. Falck, J.D. Imig. Novel mechanism of EET-induced stimulation of Ca2+-activated K+ channels in microvascular myocytes: dephosphorylation via PP2A. Experimental Biology Conference, April 2003.

    S.A. Barman, S. Zhu, M.L. Meadows, R.E. White. Protein kinase C inhibits cAMP-induced BKCa channel activity in fawn-hooded rat pulmonary arterial smooth muscle. American Thoracic Society International Conference, May 2003.

    G. Han, S. Zhu, L. Lu, X. Yu, R.E. White. Functional expression of estrogen receptors in human coronary artery smooth muscle cells. Experimental Biology Conference, April 2004.

    S.A. Barman, M.L. Meadows, S. Zhu, R.E. White. Protein kinase C activates BKCa channels in rat pulmonary arterial smooth muscle. International Vascular Biology Meeting, 2004.

    S.A. Barman, M.L. Meadows, S. Zhu, R.E. White. Protein kinase C inhibits cAMP-induced BKCa channel activity in fawn-hooded rat pulmonary arterial smooth muscle via phosphodiesterase. Thomas L. Petty Aspen Lung Conference, 2004.

    C. Dimitropoulou, S. Zhu, R.E. White, J.D. Catravas. Estrogens prevent the tracheal hyper-responsiveness to carbachol in asthma. Experimental Biology Conference, April 2005.

    S.A. Barman, S. Zhu, M.L. Meadows, R.E. White. Forskolin opens calcium- and voltage-activated potassium channel in pulmonary arterial smooth muscle via protein kinase C. American Thoracic Society International Conference, May 2005.

    S. Zhu, R.E. White, D.D. Browning, Y. Hou, M.L. Meadows, S.A. Barman. Mutation of PKC phosphorylation site 1075T on the BKCa channel α subunit modulates BKCa channel activity. Experimental Biology Conference, April 2006.

    S. Zhu, R.E. White, M.L. Meadows, S.A. Barman. PKC inhibits BKCa channel activity in pulmonary arterial smooth muscle cells through multiple signaling pathways. European Respiratory Society Annual Congress, September 2006.

    S.A. Barman, R.E. White, M.L. Meadows, S. Zhu. Function and expression of BKCa channel subunits in HEK293 cells and pulmonary arterial smooth muscle. American Thoracic Society International Conference, May 2008.

    S.A. Barman, R.E. White, M.L. Meadows, S. Zhu. PKC isozymes differently regulate BKCa channels in pulmonary arterial smooth muscle. Experimental Biology Conference, April 2009.

    S.A. Barman, R.E. White, M.L. Meadows, S. Zhu. BKCa channel expression and cAMP generation in diabetic porcine pulmonary arterial smooth muscle cells. American Thoracic Society International Conference, May 2009.

    S. Zhu, R.E. White, M.L. Meadows, S.A. Barman. Expression of BKCa channel in pulmonary arterial smooth muscle and the effect of protein kinase C phosphorylation site S1076 on the response to PKCƐ on BKCa channel activity. American Thoracic Society International Conference, May 2010.

    S. Zhu, D. Fulton, F. Chen, R.E. White, S.A. Barman. Caveolin-1 and BKCa channel activity in pulmonary arterial smooth muscle. Experimental Biology Conference, April 2012.

    S. Zhu, C. Li, G. Wu. Regulation of the cell surface traffic of α 2-adrenergic receptors by small GTPases. Experimental Biology Conference, April 2012.

  • Memberships

    Vice President of the Georgia Regents University Chinese Students and Scholars Association (GRU-CSSA), Augusta, Georgia, 2003-2005 & Board Member, 2007-2008

    Member of the Georgia Regents University International and Postdoctoral Services Office Advisory Council, Augusta, GA, 2010-2012

  • Other

    Reviewer for American Journal of Physiology, International Journal of Ophthalmology, Nutrition & Metabolism, Acta Pharmacologica Sinica, Clinical and Experimental Pharmacology and Physiology, PLOS ONE