Education
- PhD, Department of Biochemistry, University of Mysore, India, 2004
- MS, Department of Biochemistry, University of Mysore, India, 1996
- BS, University of Mysore, India, 1994
Courses
At PCOM-SOP, Dr. Shashidharamurthy involved in teaching the following courses to Doctor of Pharmacy students.
- PHAR 224G Immunology and Microbiology (coordinator)
- PHAR 150G Biochemistry
- PHAR 351G Toxicology
- PHAR 312G Integrated Therapeutics
Research
One of the major focuses of Dr. Shashidharamurthy's research is to delineate the molecular
mechanism(s) lipocalin-2 (Lcn2) during various autoimmune/inflammatory disorders such
as arthritis and lupus. This may eventually lead to development of novel therapeutic
approaches. More recently his research has shown that Lcn2 plays a protective role
during the pathogenesis of immune-complex mediated arthritis (Arthritis Rheum. 2013;65:1064-73).
The preliminary data suggests that Lcn2 knockout mice are defective in the production
of anti-inflammatory cytokines and T reg expansion during arthritis condition. These
results demonstrate that Lcn2 is a host-protective factor against systemic autoimmune
disease.
Apart from this project, our laboratory is also focused on: The individual role of
FcGamma receptor and complement proteins during the pathogenesis of immune-complex
(IC) mediated vasculitis (funded by American Heart Association), Attenuation of IC-mediated
inflammation by prostaglandin E2 receptor antagonists and Synergistic effect of IC’s
and TLR ligands during IC-mediated inflammatory disorders.
Grants
Role: Principal Investigator
Award type: Scientist Development Grant Program
Funding source: American Heart Association
Title: Blocking of immune-complex mediated vasculitis using recombinant Fc receptors.
Duration: 1/1/2011-12/31/2015
Role: Principal Investigator
Award type: Internal funding
Funding Agency: (Chief Scientific officer) CSO-funding
Title: Synergistic effect of immune-complex and TLR ligand during immune-complex mediated
disorders.
Duration: 12/1/2012-12/31/2013
Role: Principal Investigator
Award type: Internal funding
Funding Agency: CSO-funding for MS-Thesis
Title: Attenuation of antibody- mediated inflammation by prostaglandin E2 receptor
antagonists during autoimmune arthritis.
Duration: 08/1/2012-08/31/2014
Role: Co Principle investigator
Award type: Internal funding
Funding Agency: CSO-funding
Title: Attenuation of immune-complex mediated inflammation through inhibition of NFkb
activation by caffeic acid phenethyl ester (CAPE).
Duration: 12/17/2013-11/30/2015
Awards
- Early Career Faculty Award from American Association of Immunologist (2013-2015)
- American Association of Immunologist Trainee Awards. 2011 (two awards for two different
presentations)
- Scientist Development grant program Award from America Heart Association. 2011
Memberships
- American Association of Immunologist. 2005- present
- American College of Clinical Pharmacy (ACCP). 2012- present
- American Association for the Advancement of Science. 2005-2010
Editorial Service
- Biochimie 2004- present
- Comparative Biochemistry and physiology, 2004- present
- Planta Medica, 2006- present
- Nutrition Journal, 2007- present
- Current Medicinal Chemistry, 2008- present
- Immunopharmacology And Immunotoxicology, 2008- present
- Archives of Biochemistry and Biophysics, 2009- present
- Bioorganic & Medicinal Chemistry Letters, 2010- present
- European Journal of Cancer 2013- present
- Clinical and Applied Thrombosis/Hemostasis 2013- present
- Cellular Physiology and Biochemistry, 2014- present
- Plose One, 2015- present
Grant Review Study Section Member
Serving as active committee member on American Heart Association Grant review committee
under Vascular Endothelial Biology and Function - Basic Science and Immunology and
Virology - Basic Science study sections
Invited Speaker at National/International Conferences
Renowned speaker and Chairing the session (Track:5 Allergy) at 4th international conference
on Clinical and Experimental Dermatology too be held at San Antonio, Texas, USA. April
14-16, 2014.