RANGAIAH SHASHIDHARAMURTHY, PHD
Department of Pharmaceutical Sciences
Assistant Professor


Rangaiah Shashidharamurthy

Contact

Email: rangaiahsh@pcom.edu
Office: 678-407-7373

Affiliations

Adjunct Faculty at Department of Pathology, Emory University, Atlanta, GA. USA.

Dr. Shashidharamurthy's initial interest in teaching started during his training towards obtaining a PhD degree. Upon entering the Ph.D program, the most influential of his mentors were those who successfully achieved a career by combining teaching with research. As a graduate student, Dr. Shashidharamurthy learned to appreciate the aspects of teaching and research that an academic career could provide. In addition to teaching, he has also been involved in mentoring and supervising many work-study students, research assistants and postdoctoral fellows.

  • Education

    PhD, Department of Biochemistry, University of Mysore, India, 2004
    MS, Department of Biochemistry, University of Mysore, India, 1996
    BS, University of Mysore, India, 1994

  • Courses

    At PCOM-SOP, Dr. Shashidharamurthy involved in teaching the following courses to PharmD students.

    PHAR 224G Immunology and Microbiology (coordinator)
    PHAR 150G Biochemistry
    PHAR 351G Toxicology
    PHAR 312G Integrated Therapeutics

  • Research

    One of the major focuses of Dr. Shashidharamurthy's research is to delineate the molecular mechanism(s) lipocalin-2 (Lcn2) during various autoimmune/inflammatory disorders such as arthritis and lupus. This may eventually lead to development of novel therapeutic approaches. More recently his research has shown that Lcn2 plays a protective role during the pathogenesis of immune-complex mediated arthritis (Arthritis Rheum. 2013;65:1064-73). The preliminary data suggests that Lcn2 knockout mice are defective in the production of anti-inflammatory cytokines and T reg expansion during arthritis condition. These results demonstrate that Lcn2 is a host-protective factor against systemic autoimmune disease. Apart from this project, our laboratory is also focused on: The individual role of FcGamma receptor and complement proteins during the pathogenesis of immune-complex (IC) mediated vasculitis (funded by American Heart Association), Attenuation of IC-mediated inflammation by prostaglandin E2 receptor antagonists and Synergistic effect of IC’s and TLR ligands during IC-mediated inflammatory disorders.

  • Awards

    Early career Faculty Award from American Association of Immunologist (2013 - 2015)

    American Association of Immunologist Trainee Awards. 2011 (two awards for two different presentations)

    Scientist Development grant program Award from America Heart Association. 2011

  • Publications

    1. Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RA, Choudhury BP, Stowell SR, Lee JH, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R. Antibody effector functions mediated by Fc𝛾Rs are compromised during chronic LCMV infection. Immunity, 2015;42,367-78.

    2. Russell A, Mula VR, Siddiqui S, Shashidharamurthy R*. Pathological overview of rheumatoid arthritis. JSNMA. 2014; 11(Nov): 10-11.

    3. Mula VR, Russell A, Siddiqui S, Shashidharamurthy R*. An overview on pathogenic mechanisms of autoimmune arthritis. (Under Review BMC Immunology)

    4. Mula VR, Machiah D, Dalta R, Wang X, Sharma AC, Selvaraj P, Shashidharamurthy R*. Immune-complex induced, nitric-oxide mediated vascular damage is prevented by decoys Fcgamma receptors. (Under Review Scientific Reports)

    5. Mula RV and Shashidharamurthy R*. Multifaceted role of TNF- during Rheumatoid arthritis. Adv Biosci Biotech. 2013;4:937-940. invited article

    6. Shashidharamurthy R*, Machiah D, Aitken JD, Putty K, Srinivasan G, Chassaing B, Parkos CA, Selvaraj P, Matam VK. Differential role of lipocalin-2 during immune-complex mediated acute and chronic inflammation. Arthritis Rheum. 2013;65:1064-73. (*corresponding author)

    7. Ganesh T, Jiang J, Shashidharamurthy R, Dingledine R. Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS Med Chem Lett. 2013;4:616-621.

    8. Bozeman EN, Cimino-Mathews A, Machiah DK, Patel JM, Krishnamoorthy A, Tien L, Shashidharamurthy R, Selvaraj P. Expression of membrane anchored cytokines and B7-1 alters tumor microenvironment and induces protective antitumor immunity in a murine breast cancer model. Vaccine. 2013;31:2449-56.

    9. Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R, Borregaard N, Jones DP, Gewirtz AT, Vijay-Kumar M. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol. 2012;15:189:1911-9.

    10. Bozeman EN, Srivatsan S, Mohammadi H, Shashidharamurthy R, Daniels D, Selvaraj P. Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induces protective immunity in mice. Exp Oncol. 2012;34:340-7.

    11. Shashidharamurthy R*, Bozeman E, Selvaraj P. Administration of plasmid DNA encoding human FcRs blocks the immune-complex mediated inflammation in vivo in reverse passive Arthus reaction model. Gene Ther. 2012;19:877-85.

    12. D'Souza B, Bhowmik T, Shashidharamurthy R, Oettinger C, Selvaraj P, D'Souza M.Oral microparticulate vaccine for melanoma using M-cell targeting. J Drug Target. 2012 Feb;20(2):166-73

    13. Shashidharamurthy R*, Bozeman E, Patel J, Selvaraj P. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach as an alternative for cancer vaccine development. Med Res Rev. 2012 Nov;32:1197-219.

    14. Bhowmik T, D’Souza B, Shashidharamurthy R, Oettinger C, Selvaraj P and D’Souza MJ. A novel microparticulate vaccine for melanoma cancer using transdermal delivery. J. Microencap, 2011;28:294-300.

    15. Goins C.L, Chappell C.P, Shashidaramurthy R, Selvaraj P and Jacob J. Immune complex mediated enhancement of secondary antibody responses. J Immunol. 2010;184:6293-6298.

    16. Bozeman E, Shashidharamurthy R, Paulos S.A, Palaniappan R, D’Souza M, Selvaraj P. Cancer vaccine development: Designing tumor cells for greater immunogenicity. Frontiers In Bioscience, 2010; 15: 309-320.

    17. Shashidharamurthy R, Ravichandran P, Amono A, Zhang F, Ezekwudo D, Amano A, Zhu C, Selvaraj P. Dynamics of the interaction of human IgG subtype immune-complexes with cells expressing R and H allelic forms of a low affinity Fc gamma receptor CD32A. J Immunol. 2009; 183: 8216-8224.

    18. Bozeman E, Jennifer H, Shashidharamurthy R, Selvaraj P. Commentaries on role of PD1 molecules in bacterial and viral infections. Immunotherapy. 2009; 1: 525-527. (all authors contributed equally)

    19. Bumgarner GW, Shashidharamurthy R, Nagarajan S, D’Souza MJ, and Selvaraj P. Surface engineering of microparticles using a novel protein transfer technique: Potential applications in vaccine adjuvant development and targeted drug delivery. J. Control release. 2009;137:90-97.

    20. Ezekwudo D, Shashidharamurthy R, Devineni D, Palaniappan R, Selvaraj P. Down regulation of anti-apoptotic protein and induction of cell death in radioresistant human prostate adenocarcinoma cell line (PC-3) by methyl jasmonate. Cancer Lett. 2008: 270:277-285.

    21. Selvaraj P, Yerra A, Tien L and Shashidharamurthy R. Custom designing therapeutic cancer vaccines: Delivery of immunostimulatory molecule adjuvants by protein transfer. Hum Vaccin. 2008; 4: 384 – 388.

    22. Shashidharamurthy R, Hennigar RA, Fuchs S, Palaniswami P, Sherman M, Selvaraj P. Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fc receptors and can be effectively blocked by decoy Fc receptors. Blood. 2008; 111:894-904.

    23. Shashidharamurthy R, Amano A, Ezekwudo D, Selvaraj P. Analysis of competitive interaction of H and R allelic forms of CD32A with rabbit IgG immune-complex. Proc. Intl. Cong. Immunol. 2007, p513-522.

    24. Wang YC, Sashidharamurthy R, Nagarajan S, Selvaraj P. B7-1-HSA (CD80-CD24), a recombinant hybrid costimulatory molecule retains ligand binding and costimulatory functions. Immunol Lett. 2006; 105. 185-92.

    25. Shashidharamurthy R, Koteiche HA, Dong J, McHaourab HS. Mechanism of chaperone function in small heat shock proteins: dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme. J Biol Chem. 2005; 280. 5281-9.

    26. Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor. J Immunol. 2003; 17. 4539-51.

    27. Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. J Immunol. 2003; 170. 5133-42.

    28. Shashidharamurthy R, Mahadeshwaraswamy Y.H, Ragupathi L, Vishwanath B.S, Kemparaju K. Systemic pathological effects induced by cobra (Naja naja) venom from geographically distinct origins of Indian peninsula. Exp Toxicol Pathol. 2010; 62. 587–592.

    29. Shashidharamurthy R, Kemparaju K. Region-specific neutralization of Indian cobra (Naja naja) venom by polyclonal antibody raised against the eastern regional venom: A comparative study of the venoms from three different geographical distributions. Int Immunopharmacol. 2007; 7. 61-69.

    30. Shashidharamurthy R, Kemparaju K. A neurotoxic phospholipase A2 variant: isolation and characterization from eastern regional Indian cobra (Naja naja) venom. Toxicon. 2006; 47. 727-33.

    31. Girish KS, Shashidharamurthy R, Nagaraju S, Gowda TV, Kemparaju K. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie. 2004; 86. 193-202.

    32. Shashidharamurthy R, Jagadeesha DK, Girish KS, Kemparaju K. Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution. Mol Cell Biochem. 2002; 229. 93-101.

    33. Jagadeesha DK, Shashidharamurthy R, Girish KS, Kemparaju K. A non-toxic anticoagulant metalloprotease: purification and characterization from Indian cobra (Naja naja naja) venom. Toxicon. 2002; 40. 667-75.

  • Memberships

    American Association of Immunologist. 2005- present
    American College of Clinical Pharmacy (ACCP). 2012- present
    American Association for the Advancement of Science. 2005-2010

  • Other

    Grant Support

    Role: Principal Investigator
    Award type: Scientist Development Grant Program
    Funding source: American Heart Association
    Title: Blocking of immune-complex mediated vasculitis using recombinant Fc receptors.
    Duration: 1/1/2011-12/31/2015

    Role: Principal Investigator
    Award type: Internal funding
    Funding Agency: (Chief Scientific officer) CSO-funding
    Title: Synergistic effect of immune-complex and TLR ligand during immune-complex mediated disorders.
    Duration: 12/1/2012-12/31/2013

    Role: Principal Investigator
    Award type: Internal funding
    Funding Agency: CSO-funding for MS-Thesis
    Title: Attenuation of antibody- mediated inflammation by prostaglandin E2 receptor atagonists during autoimmune arthritis.
    Duration: 08/1/2012-08/31/2014

    Role: Co Principle investigator
    Award type: Internal funding
    Funding Agency: CSO-funding
    Title: Attenuation of immune-complex mediated inflammation through inhibition of NFkb activation by caffeic acid phenetchyl ester (CAPE).
    Duration: 12/17/2013-11/30/2015

    Editorial Service

    a. Biochimie 2004- Present
    b. Comparative Biochemistry and physiology, 2004- present
    c. Planta Medica, 2006- present
    d. Nutrition Journal, 2007- present
    e. Current Medicinal Chemistry, 2008-present
    f. Immunopharmacology And Immunotoxicology, 2008-present
    g. Archives of Biochemistry and Biophysics, 2009-present
    h. Bioorganic & Medicinal Chemistry Letters, 2010-present
    i. European Journal of Cancer 2013-Present
    j. Clinical and Applied Thrombosis/Hemostasis 2013-present
    k. Cellular Physiology and Biochemistry, 2014-present
    l. Plose One, 2015-present

    Grant Review Study section member

    Serving as active committee member on American Heart Association Grant review committee under Vascular Endothelial Biology and Function - Basic Science and Immunology and Virology - Basic Science study sections

    Invited Speaker at national/international conferences

    Renowned speaker and Chairing the session (Track:5 Allergy) at 4th international conference on Clinical and Experimental Dermatology too be held at San Antonio, Texas, USA. April 14-16, 2014.