QIAN CHEN, PHD
Department of Bio-Medical Sciences - Philadelphia
Research Assistant Professor of Microbiology and Immunology


Qian Chen, PhD

Contact

Email: qianch@pcom.edu
Office: 215-871-6153
Research Page

Affiliations

Division of Research

Dr. Chen is highly committed in using her medical knowledge and clinical/research experience to educate PCOM students. Since 2008, she has taught in pharmacology courses for the DO and Biomedical Sciences programs at PCOM, and since 2013 she has given biochemistry lectures to Biomedical Sciences students. Her teaching philosophy is student-centered and aims to provide students with accurate knowledge while nurturing them to develop critical thinking skills. She favors classroom dynamics that permit dialogue and foster student input, and she uses standardized practice questions in lecture to develop student problem-solving skills and to receive instantaneous feedback. Teaching also provides her the excellent opportunity to communicate with medical and graduate students, and to foster research work directed at meeting clinical needs. Additionally, she takes advantage of faculty strategic training lectures provided by PCOM to improve teaching skills by adapting to modern medical educational needs.

Dr. Chen has served as thesis advisor or committee member for several Biomedical Sciences master's students, and she also provides research training to DO and graduate work-study students in the lab. Moreover, she has established research collaborations with internal and external senior researchers, such as Dr. Greene, Dr. Barsotti, Dr. Young, and Dr. Hatcher at PCOM, and Dr. Weis at Texas Tech University. The collaborations have led to journal paper publications, abstract/poster presentations at national scientific meetings, and grant submissions.

  • Education

    M.D./Ph.D. Xi’an Jiao Tong University, School of Medicine, P.R. China, 2001
    MS, Xi’an Medical University, P.R. China, 1998
    BS, Xi’an Medical University, P.R. China, 1995

  • Courses

    2008-present Pharmacology lectures for Biomedical Sciences program; Co-coordinator for Pharmacology for Biomedical Sciences

    2010-present Pharmacology lectures for D.O. program

    2013-present Biochemistry lectures for Biomedical Sciences program

  • Research

    For the past decade, Dr. Chen's research has been conducted in topics related to the cardiovascular system. Currently, she is interested in finding the key mechanisms involved in various cardiovascular diseases, such as myocardial infarction, stroke and diabetes. Vascular endothelial dysfunction and inflammation are two critical events initiating the pathogenesis of these diseases, and in her lab multiple animal models and biochemical techniques are combined to evaluate blood vessel biochemical properties (e.g., blood nitric oxide and hydrogen peroxide) in real-time, organ blood perfusion, and inflammation (i.e., leukocyte-endothelial interactions). Her research will clarify the roles of endothelial nitric oxide synthase, NADPH oxidase, damaged mitochondria, and key enzyme regulations and signaling pathways, which will provide new treatment strategies for cardiovascular diseases.

    Research Keywords

    Vascular endothelial dysfunction
    Leukocyte-endothelial interactions
    Hyperglycemia
    Myocardial ischemia/reperfusion injury
    Inflammation
    Oxidative stress
    Endothelial nitric oxide synthase
    Hydrogen peroxide
    Nitric oxide

  • Publications

    Selected Publications

    1) Nina Blakeman, Qian Chen, Jasmine Tolson, Brian Rueter, Brian Diaz, Brendan Casey, Lindon H. Young, Margaret T. Weis. Triacsin C, a Fatty Acyl CoA Synthetase Inhibitor, Improves Cardiac Performance Following Global Ischemia. Am. J. Biomed. Sci., 4(3), 249-261, 2012.
    2) Kerry-Anne A. Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S. Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Iyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng and Lindon H. Young. The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). Naunyn-Schmiedeberg’s Arch of Pharmacol 385(1):27-38, 2012.
    3) Matthew Montgomery, Jovan Adams, Jane Teng, Biruk Tekelehaymanot, Regina Ondrasik, Issachar Devine, Kerry-Anne Perkins, Qian Chen, Robert Barsotti, and Lindon H. Young. Myristoylated protein kinase C epsilon peptide inhibitor exerts cardioprotective effects in rat and porcine myocardial ischemia/reperfusion: A translational research study. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 178-179, 2013.
    4) Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.
    5) Alexandra C. Lopez, Qian Chen, Brittany L. Deiling, Edward S. Iames, Robert Barsotti, and Lindon H. Young. The Effects of Modulating Endothelial Nitric Oxide Synthase (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 58-59, 2013.
    6) Galbreath T., Chen Q., Ondrasik R., Bertolet M., Barsotti R., Young L.. Effects of Mitochondrial-Targeted Antioxidants on Real-time Nitric Oxide and Hydrogen Peroxide Release in Hind Limb Ischemia and Reperfusion (I/R). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 46-47, 2013.
    7) Issachar Devine, Qian Chen, Regina Ondrasik, William Chau, Katelyn Navitsky, On Say Lau, Christopher W. Parker, Kyle D. Bartol, Brendan Casey, Robert Barsotti, Lindon H. Young. Cardioprotective Effects of Cell Permeable NADPH oxidase inhibitors in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 42-43, 2013.
    8) Matthew L. Bertolet, Michael Minni, Tyler Galbreath, Robert Barsotti, Lindon H. Young, and Qian Chen. Effects of Selective NADPH Oxidase Inhibitors on Real-Time Blood Nitric Oxideand Hydrogen Peroxide Release in Acute Hyperglycemia. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 34-35, 2013.
    9) Hung T. Pham, Robert Barsotti, Amber N. Koon, Brian Rueter, Lindon H. Young, and Qian Chen. The Role of NADPH Oxidase on L-NAME-induced Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 66-67, 2013.
    10) Regina Ondrasik, Qian Chen, Katelyn Navitsky, William Chau, Issachar Devine, On S. Lau,Tyler Galbreath, Robert Barsotti, and Lindon H. Young. Cardioprotective Effects of Mitochondrial-Targeted Antioxidants in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 64-65, 2013.
    11) Allan M. Prior, Man Zhang, Nina Blakeman, Palika Datta, Hung Pham, Qian Chen, Lindon H. Young, Margaret T. Weis, Duy H. Hua. Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury. Bioorganic & Medicinal Chemistry Letters 24 (4):1057-1061, 2014.
    12) Qian Chen, Hung Pham, Manoj Jivani, Jovan Adams, Michael Dawley, Michael Hart, Simon Okewole, Lindon Young. Protein Kinase C delta peptide activator exerts anti-inflammation and cardio-protective effects. Medical Research Archives issue 2: 1-22, 2015
    13) Rui Gao, Wanquan Wu, Junxi Xiang, Yi Lv, Xinglong Zheng, Qian Chen, Haohua Wang, Bo Wang, Zhengwen Liu, Feng Ma. Hepatocyte culture in autologous decellularized spleen matrix. Organogenesis 11(1):16-29, 2015

  • Memberships

    2005-2014 Neuroscience Society, Regular Member
    2007-present Sigma Xi Society, Regular Member
    2011-present American Peptide Society, Regular Member
    2013-present American Heart Association, Regular Member

  • Grants

    Center for Chronic Disorders of Aging (CCDA) at PCOM (07/01/2013-06/30/2014)
    Title: The role of mitochondria in acute hyperglycemia: activation of vascular NADPH oxidase and eNOS uncoupling
    Role on Project: PI

    Pennsylvania State Tobacco Grant (grant #4100057680) 01/01/2012-12/31/2015
    Title: “Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues”
    Role on Project: Co-investigator

     

  • Other

    Volunteer and Leadership Activities
    • Reviewer: Evidence-Based Complementary and Alternative Medicine