LORI REDMOND, PHD
Department of Bio-Medical Sciences - Georgia
Associate Professor of Anatomy


Lori Redmond, PhD

Contact

Email: loriha@pcom.edu
Office: 678-225-7462
Research Page

Dr. Redmond has directed and taught in numerous courses including those in neuroscience and pharmacology in graduate and medical programs since her first faculty appointment over 10 years ago.

  • Courses

    Dr. Redmond currently serves as course director for Basic and Clinical Neuroscience, Reproductive and Genitourinary Medicine, Developmental Neuroscience, Microanatomy and Embryology, and Scientific Communication.

    Dr. Redmond participates in teaching in Structural Principles of Osteopathic Medicine, Cellular and Molecular Basis of Medicine, Basic and Clinical Neuroscience, Reproductive and Genitourinary Medicine, Gastroenterology, Developmental Neuroscience, Microanatomy and Embryology, and Scientific Communication.

  • Research

    The incidence of intellectual disability is 1-3% in the human population (NIH/NLM) and the number of autistic individuals is on the rise. A shared pathology in human and mouse models of intellectual disability, neurodegenerative diseases, and other neurological disorders is abnormal cerebral cortical organization and neuronal morphology. The research in Dr. Redmond’s lab examines the roles of proteins and genes in the development and maturation of the cerebral cortex. The role of signaling proteins, such as CaMKIIβ, that translate neuronal activity into changes in neuronal shape and connections is the focus of Dr. Redmond’s research. Genetically modified mice, immunohistochemical, biochemical, and molecular biological approaches are used to elucidate the role of signaling proteins in the development of the central nervous system and differentiation of neurons.

  • Publications

    Selected Publications

    Hardy, LR (2012) Fluorescent recovery after photobleaching (FRAP) with a focus on F-actin. Current Protocols in Neuroscience, Chapter 2: Unit 2.17.

    Nagendran, T and Hardy, LR (2011) Calcium/calmodulin-dependent protein kinase IV mediates distinct features of basal and activity-dependent dendrite complexity. Neuroscience 199:548-562.

    Lin, Y and Redmond, L (2008) CaMKIIβ binding to stable F-actin in vivo regulates F-actin filament stability. Proc Natl Acad Sci USA, 16:15791-15796.

    Ha, S and Redmond, L (2008) ERK mediates activity dependent neuronal complexity via sustained activity and CREB-mediated signaling. Dev. Neurobio. 68:1565-1579.

    Redmond, L, Kashani, AH and Ghosh, A (2002) Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron 34:999-1010.

    Redmond, L, Oh, SR, Hicks, C, Weinmaster, G and Ghosh, A (2000) Nuclear Notch1 signaling and the regulation of dendritic development. Nature Neurosci. 3:30-40.

    Selected Presentations

    Lin, YC, Wallis, K, Yi, X, Zheng J and Hardy, LR (2010) CaMKII in neuronal development. Towards Defining the Pathophysiology of Autistic Behavior, Keystone Symposium, Snowbird, UT.

  • Grants

    PI: Lori R Hardy, PhD
    CCDA Pilot grant
    CaMKIIβ regulation of the actin cytoskeleton
    Direct costs: $9,000
    07/01/12-06/30/13

    PI: Lori R Hardy, PhD
    1 R01 NS046809
    Calcium signaling in neuronal differentiation
    Direct costs: $971,250
    03/01/04 – 08/31/10

    PI: Lori R Hardy, PhD
    IGP PSRP
    CaMKIIβ in neuronal development
    Direct costs: $25,000
    10/01/09 - 09/30/10

    PI: Robert K. Yu
    CoInv: Lori R Hardy, PhD; and several others
    5T32NS045543-04
    Neurodegenerative diseases and neural repair
    Direct costs: Funding for 1 predoctoral and 3 postdoctoral trainees
    01/07/05 – 06/30/10