Department of Bio-Medical Sciences - Georgia
Associate Professor of Biochemistry

Francis E. Jenney Jr., PhD


Office: 678-225-7562
Research Page

I teach Biochemistry, Molecular Biology, and Genetics in both the Masters and the DO Programs. In order to understand human biology ‘mind, body, and spirit’, it is critical to understand the molecular mechanisms which are the foundation. In order to incorporate scientific thinking and evidence-based medicine, I include recent scientific literature in all of our discussions. I cover topics such as basic metabolism, the human Microbiota, nutritional biochemistry, and the genetics of various diseases such as cardiac diseases, neurological disorders, and cancer.

The research in my lab involves the study of metalloproteins from hyperthermophiles. These proteins are highly stable and hold great promise for both medical and commercial processes. We are in particular looking at utilizing these proteins as potential treatments for cancer and ischemia/reperfusion injury, as well as the potential role of hydrogenases in biofuel production.

At home Dr. Jenney enjoys gardening and learning how to relax from his dog Clarence, aka “Mr. Fabulous”.

  • Education

    PhD, University of Pennsylvania, Philadelphia, PA

  • Publications

    Selected Publications

    Kamali, S., H. Wang, D. Mitra, H. Ogata, W. Lubitz*, B.C. Manor, T.B. Rauchfuss, D. Byrne, V. Bonnefoy, F.E. Jenney Jr., M.W.W. Adams, Y. Yoda, E. Alp, J. Zhao, and S.P. Cramer. 2013. Active Site Fe-CN and Fe-CO Vibrations in [NiFe] Hydrogenase – Observation by Nuclear Resonance Vibrational Spectroscopy. Angewandte Chem. Int. Ed. Engl. 52:724-728.

    Chandrayan, S.K., P.M. McTernan, R.C. Hopkins, J. Sun, F.E. Jenney, Jr., and M.W.W. Adams. 2012. Engineering hyperthermophilic archaeon Pyrococcus furiosus to overproduce its cytoplasmic [NiFe]-hydrogenase. J. Biol. Chem. 287:3257-3264.

    Hopkins, R.C., J. Sun, F.E. Jenney, Jr., S.K. Chandrayan, P.M. McTernan, and M.W.W. Adams. 2011. Homologous expression of a subcomplex of Pyrococcus furiosus hydrogenase that interacts with pyruvate ferredoxin oxidoreductase. PLoS ONE. 6:e26569.

    Lipscomb, G.L., K. Stirrett, G.J. Schut, F. Yang, F.E. Jenney, Jr., R.A Scott, M.W.W. Adams, and J. Westpheling. 2011. Natural competence in the hyperthermophilic archaeon Pyrococcus furiosus facilitates genetic manipulation: construction of multiple markerless deletions of genes encoding the two cytoplasmic hydrogenases. Appl. Environ. Microbiol. 77(7):2232-2238.

    Cvetkovic, A., A.L. Menon, M.P. Thorgersen, J.W. Scott, F.L. Poole, II, F.E. Jenney, Jr., W.A. Lancaster, J.L. Praissman, S. Shanmukh, B.J. Vaccaro, S.A. Trauger, E. Kalisiak, J.V. Apon, G. Siuzdak, S.M. Yannone, J.A. Tainer, and M.W.W. Adams. 2010. The Metalloproteomes of Microorganisms are Largely Uncharacterized. Nature. 466:779-782.

    Sun, J., R.C. Hopkins, F.E. Jenney, Jr., P. McTernan, and M.W.W. Adams. 2010. Heterologous expression and maturation of an NADP-dependent [NiFe]-Hydrogenase: A Key Enzyme in Biofuel Production. PLoS One. 5:e10526.

    Hura, G.L., A.L. Menon, M. Hammel, R. Rambo, F.L. Poole II, S. Tsutakawa, F.E. Jenney, Jr., S. Classen, K.A. Frankel, R.C. Hopkins, S.J. Yang, J.W. Scott, B. Dillard, M.W.W. Adams, and J.A. Tainer. 2009. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS). Nature Methods. 6:606-612.

    Menon, A.L., F.L. Poole, II, A. Cvetkovic, S.A. Trauger, E. Kalisiak, J.W. Scott, S. Shanmukh, J. Praissman, F.E. Jenney, Jr., W.R. Wikoff, J.V. Apon, G. Siuzdak, and M.W.W. Adams. 2009. Novel Multiprotein Complexes Identified in the Hyperthermophilic Archaeon Pyrococcus furiosus by Non-denaturing Fractionation of the Native Proteome. Molec. Cell. Proteomics. 8:735-751.

    Chou, C.-J., F.E. Jenney, Jr., M.W.W. Adams, and R.M. Kelly. 2008. Hydrogenesis in hyperthermophilic microorganisms: Implications for biofuels. Metabolic Engineer. 10:393-404.

    Jenney, Jr., Francis E. and M.W.W. Adams. (2008) Hydrogenases of the model hyperthermophiles. Annals NY Acad. Sci. 1125:252-266.

    Jenney, Jr., F.E. and M.W.W. Adams. 2007. The impact of extremophiles on structural genomics (and vice versa). Extremophiles. 12:39-50.

    Poole, F.L. II, B.A. Gerwe, R.C. Hopkins, G.J. Schut, M.V. Weinberg, F.E. Jenney, Jr., M.W.W. Adams. 2005. Defining genes in the genome of the hyperthermophilic archaeon Pyrococcus furiosus: implications for all microbial genomes. J. Bacteriol. 187:7325-7332.

    Sugar, F.J., F.E. Jenney, Jr., F.L. Poole II, P.S. Brereton, M. Izumi, C. Shah, M.W.W. Adams. 2005. Comparison of small-and large-scale expression of selected Pyrococcus furiosus genes as an aid to high-throughput protein production. J. Struct. Funct. Genomics. 6:149-158.

    Jenney, Jr., F.E., P.S. Brereton, M. Izumi, F.L. Poole II, C. Shah, F.J. Sugar, H.-L. Lee, and M.W.W. Adams. 2005. High-throughput production of Pyrococcus furiosus proteins: considerations for metalloproteins. J. Synch. Rad. 12:8-12.

    Grunden, A.M., F.E. Jenney, Jr., K. Ma, M. Ji, M.V. Weinberg, M.W.W. Adams. 2005. In vitro reconstitution of an NADPH-dependent superoxide reduction pathway from Pyrococcus furiosus. Appl. Environ. Microbiol. 71:1522-1530.

    Tempel, W., Z.J. Liu, F.D. Schubot, A. Shah, M.V. Weinberg, F.E. Jenney, Jr., W.B. Arendall 3rd, M.W.W. Adams, J.S. Richardson, D.C. Richardson, J.P. Rose, and B.C. Wang. 2004. Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. Proteins 57:878-882.

    Chatake, T., K. Kurihara, I. Tanaka, I. Tsyba, R. Bau, F.E. Jenney, Jr., M.W.W. Adams, and N. Niimura. 2004. A neutron crystallographic analysis of a rubredoxin mutant at 1.6 A resolution. Acta Crystallogr. D Biol. Crystallogr. 60:1364-1373.

    Bergmann U., W. Sturhahn, D.E. Linn Jr., F.E. Jenney, Jr., M.W. Adams, K. Rupnik, B.J. Hales, E.E. Alp, A. Mayse, and S.P. Cramer. 2003. Observation of Fe-H/D modes by nuclear resonant vibrational spectroscopy. J Am Chem Soc. 125:4016-4017.

    Clay M.D., C.A. Cosper, F.E. Jenney, Jr., M.W. Adams, and M.K. Johnson. 2003. Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase. Proc Natl Acad Sci U S A. 100:3796-3801.

    Adams M.W., F.E. Jenney, Jr., M.D. Clay, and M.K. Johnson. 2002. Superoxide reductase: fact or fiction? J Biol Inorg Chem. 7:647-52.

    Jenney, F.E. Jr., and M.W. Adams. 2001. Rubredoxin from Pyrococcus furiosus. Methods Enzymol. 334:45-55.

    Adams M.W., J.F. Holden, A.L. Menon, G.J. Schut, A.M. Grunden, C. Hou, A.M. Hutchins, F.E. Jenney, Jr., C. Kim, K. Ma, G. Pan, R. Roy, R. Sapra, S.V. Story, M.F. Verhagen. 2001. Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol. 183:716-724.

    Jenney, Jr., F.E., M.F.J.M. Verhagen, X. Cui, M.W.W. Adams. 1999. Anaerobic microbes: oxygen detoxification without superoxide dismutase. Science 286:306-309.

    Selected Presentations

    October 25, 2013 “Genetic marker testing – new directions”. Georgia Osteopathic Medical Association, Annual CME Convention, Suwanee, GA.

    June 12, 2010 “What's coming down the tract - the growing roles of diet, flora, and genetics in treatment of GI diseases”. Georgia Osteopathic Medical Association, Annual CME Convention, Hilton Head, SC.

    July 30, 2007 “Multiple NiFe-Hydrogenases in the Hyperthermophile Pyrococcus furiosus”. Society for Industrial Microbiology, Annual Meeting, Denver, CO.

    July 10, 2007 “The Pathway and Enzymology of Hydrogen Production by Thermotoga maritima”. Thermotoga Workshop 2007, California Institute for Telecommunications and Information Technology (Calit2), San Diego, CA.

    January 12, 2005 "Development of high-throughput methods for expression screening and protein purification using the model organism Pyrococcus furiosus". Protein Process Development meeting, Cambridge Healthtech Institute, San Diego, CA

    June 29, 2003 "HTP - multifaceted expression and protein purification system using Pyrococcus furiosus". Second BioXAS Study Weekend: Genomics and BioXAS, Orsay, France

  • Other

    Volunteer and Leadership Activities

    Advisor for GA PCOM Green Team and Alpha Epsilon Lambda Graduate Honor Society