DESUO WANG, PHD, MD
Department of Pharmaceutical Sciences
Associate Professor


Desuo Wang, PhD, MD

Contact

Email: desuowa@pcom.edu
Office: 678-407-7344
Research Page

Dr. Desuo Wang has more than 14 years experience teaching in PharmD programs. He coordinated and taught Introduction to Pharmacology and Pharmacology I and II as well as courses for the graduate program in the College of Pharmacy at the University of South Carolina. At PCOM’s School of Pharmacy, he coordinates and teaches Anatomy, Anatomy Lab and Integrated Therapeutics III and has participated in teaching Physiology and Pathophysiology I, Integrated Therapeutics I and APPE research rotation.

Dr. Wang practices Tai Ji regularly. He can play some ping-pong and just started to learn how to hit golf balls.

  • Education

    PhD (Pharmacology), College of Medicine, University of Florida, 1995
    MS (Neuroscience), Shanxi Medical University, Taiyuan, China, 1985
    BS (Medicine), Shanxi Medical University, Taiyuan, China, 1982

  • Research

    Dr. Wang is interested in research and development of new drugs that may affect the cardiovascular system, metabolism homeostasis and central nervous responses. Previously, Dr. Wang’s research had been funded by NIEHS/NIH, NIH, and drug company CV Therapeutics, Inc (California). At PCOM, Dr. Wang’s research project has been funded by intramural research programs such as the CCDA center and the CSO office.

  • Awards

    Researcher of the Year, College of Pharmacy (USC), 2005
    NIH Merit Award, for helping to publish CEHP journal by NIEHS/NIH, 2001
    Transition to Independent Position Award, NIEHS/NIH, 2000
    2000 Fare Award, National Institute of Health, 1999
    Research Fellowship, American Heart Association (FL Affiliate), 1995
    Outstanding Student of University of Florida, 1994
    Procter & Gamble Professional Opportunity Award, Am. Physiol. Society, 1993
    Elite Young Researcher Award, Chinese Physiological Society, 1988

  • Publications

    Selected Publications

    Wang D and Belardinelli L: Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes. Am. J. Physiol., 1994; 267: H2420 29

    Wang D, Shryock JC, and Belardinelli L: Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells. Circ. Res., 1996; 78: 697 706

    Wang D, Martens JR, Posner P, Sumners C, and Gelband CH: Angiotensin II regulation of intracellular culcium in astroglia cultured from rat hypothalamus and brainstem. J. Neurochem., 1996; 67:996 1004

    Wang D and Armstrong DL: Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea pig atrial myocytes. J. Physiol. 2000; 529 Pt 3:699-705

    Desuo Wang, Ting Wang: A novel approach to using PDE4 inhibitor for antihypertensive therapy. Current Opinion in Investigational Drugs. 2005, 6(3):283-288

    Desuo Wang and Xiangli Cui. Evaluation of PDE4 inhibition for COPD. Int J Chron Obstruct Pulmon Dis. 2006 ;1 (4):373-9

    Binfeng Xia, Ting Wang, Laura M. Fox, Desuo Wang. HPLC/MS/MS analysis of 3-carbamyl-4-methylpyrrole analog MNP001, a highly potent antihypertensive agent, in rat plasma. Journal of chromatography B. 2009, 877(20-21), 1867-1872.

    Binfeng Xia, Desuo Wang, Laura M. Fox. Preclinical Pharmacokinetics and Metabolism of MNP001, A Piperidine Analog of 3-Carbamyl Compounds. Biopharmaceutics & Drug Disposition 2011, 32(1): 25-37

    Kirsten Hoyer, Yejia Song, James Balschi, Joanne S. Ingwall, Desuo Wang, Luiz Belardinelli, John C. Shryock. Blocking the late sodium current reduces intracellular sodium accumulation and metabolic, mechanical, and electrical dysfunction during sodium pump inhibition The Journal of Pharmacology and Experimental Therapeutics (JPET). 2011, 337: 513-527

    Selected Presentations

    Desuo Wang. Ambient Particulate Matters: Poison Cardiac Ion Channels.
    http://www.epa.gov/ncer/publications/workshop/9-28-2004/abstract/wang.html

    Ting Wang, Walt Sowell, and Desuo Wang. Structure-Activity relationship of Substituted 3-Carbamyl-4-Methylpyrroles As Potential Antihypertensive Agents. Experimental Biology 2011 (April 9-13, 2011. Washington DC; Abstract # 6557)

  • Memberships

    PCOM Committee Service:
    Faculty Search Committee
    Admissions Committee
    Promotion and Tenure Committee (Chair)
    IACUC committee

  • Grants

    NIEHS/NIH
    Funding period: 2001-2004
    Project title: Effects of Dioxins (TCDD) on Cardiac ion Channels.
    Principal Investigator: Desuo Wang
    Budget: $324,000

    NIEHS/NIH
    Funding period: 2005-2007
    Project title: Ambient particulate matters poison cardiac ion channels.
    Principal Investigator: Desuo Wang
    Budget: $430,000

    University of South Carolina
    Cancer Complementary and Alternative Medicine Center at University of South Carolina
    Funding period: 2004-2005
    Co-investigator: Desuo Wang (PI for project#4 with an independent budget of $40,000)
    Budget: $250,000

    CV Therapeutics, Inc (California)
    Funding period: 2008-2009
    Project title: Mechanism of cardiac protective effect of inhibitors of late sodium current.
    Principal Investigator: Desuo Wang
    Budget: $195,000

    CCDA (PCOM)
    Funding period: 2010-2011
    Project title: Dually Targeting L-type Ca2+ Channel and Type 4 Phosphodiesterase for Treatment of Obesity
    Principal Investigator: Desuo Wang
    Budget: $8,000

    CCDA (PCOM)
    Funding period: 2012-2013
    Project title: Angiotensin II and glutamate additively or synergistically disrupt the intracellular Ca2+ homeostasis of astroglia
    Principal Investigator: Desuo Wang
    Budget: $9,600