Dr. Appelt is a professor of Neuroscience in the department of Bio-Medical Sciences. She has served as the director for Basic and Clinical Neuroscience course in the DO curriculum and the director of the Neuroscience course in the Biomedical master program. Dr. Appelt lectures on neuroanatomy and participates in neuroanatomy labs in the DO SPOM course, Physician Assistant Studies, and Psychology program. In addition, Dr. Appelt is the director for the dual degree DO/PhD. program in Cellular and Molecular Biology designed to develop physician-scientist.
Post-Doctoral Fellowship, Hahnemann University
PhD, Drexel University College of Medicine
BS, Juniata College
Dr. Appelt has done extensive research in the field of aging and is recognized for her work on Alzheimer’s disease. Dr. Appelt is the director of PCOM’s Biological Imaging Facility and is investigating pathogen involvement as a trigger for developing Alzheimer’s disease. She is particular interesting in understanding the effects Chlamydia pneumoniae and HSV exert on the central nervous system that result in the neuropathology observed in Alzheimer’s disease. Her laboratory uses high resolution electron microscopy, confocal microscopy and epifluorescent microscopy to study cellular structures.
American Society for Cell Biology-Glenn Foundation Award for Outstanding Research
in Aging (1996)
Professor of the Year 2008 – Philadelphia College of Osteopathic Medicine
Kappa Sigma Phi Award for Osteopathic education (2003)
Lindback Distinguished Teaching Award (2013)
Balin, B.J., Appelt, D.M., Little, C.S., Hammond, C.J., Whittum-Hudson, J.A., Hudson, A.P.: Chlamydophila (Chlamydia) pneumoniae in Alzheimer’s disease. In: Microbial Infections of the Neurologic System. Springer Publishers; Edited by Andreas Seyfang, H. Friedman, and M. Bendinelli, 2007.
Brian J. Balin, C. Scott Little, Christine J. Hammond, Denah M. Appelt, Judith A. Whittum-Hudson, Hervé C. Gérard, and Alan P. Hudson,. Chlamydophila pneumoniae and the etiology of late-onset alzheimer's disease. J Alzheimers Dis. 2008; 13(4):371-380. PMID: 18487846
Appelt,D, Roupas,M, Way,D, Bell,MG, Albert,E Christine J. Hammond, and Brian J. Balin: Inhibition of Apoptosis in Neuronal cells Infected with Chlamydophila (Chlamydia) pneumoniae (BMC Neurosci. 2008 Jan 24;9(1):13)
Brian J. Balin, C. Scott Little, Christine J. Hammond, Denah M. Appelt, Judith A. Whittum-Hudson, Hervé C. Gérard, and Alan P. Hudson, Chlamydophila pneumoniae and the etiology of late-onset Alzheimer’s disease, J. of Alzheimer Disease13,371-380 2008
Galluzzi KE, Appelt DM, Balin BJ. Modern care for patients with Alzheimer disease: rationale for early intervention. J Am Osteopath Assoc. 2010 Sep;110(9 Suppl 8):S37-42.PMID: 20926742
Balin, B.J., Hammond, C.J., Little, C.S., Appelt, D.M., Hingley, S.T.: Evidence for an Infectious Etiology in Alzheimer’s disease. In: Advanced Understanding of Neurodegenerative Diseases, Raymond Chuen-Chung Chang (Ed.), ISBN: 978-953-307-529-7, Intech, Rijeka, Croatia, 2011
Thacker, J.D., Balin, B.J., Appelt, D.M., Sassi-Gaha, S., Purohit, M., Rest, R.F., Artlett, C.M.: Host-response to injury and infection and development of a first-in-class, broad-spectrum, anti-infective drug. Antimicrobial Agents and Chemo., epub Jan. 30, 2012.
1997-The Ultrastructural Analysis of Paired Helical Filaments found in Alzheimer’s Disease: Pathology Dept., Univ. of Pennsylvania
1997-The Involvement of Transglutaminase and Isopeptidase in Alzheimer’s Disease: Cephalon
1997-An Interplay of a Novel Isopeptidase and Transglutaminase in Deposits of Amyloid and Tangles Found in Alzheimers Disease: Wyeth Ayerst
1998-Emerging Pathogens Associated With Alzheimer’s disease: Eli Lilly
2001-Pathogen Entry through the Blood Brain Barrier: Consequences of Chlamydia Pneumonia Infection in Human Monocytes and Brain Endothelial Cells-AOA
2002- Induction of Alzheimer's Disease-like Pathology in the Brains of Young, Non-Transgenic, BALB/c Mice Following Infection with Chlamydia pneumoniae: A Model for Late Onset/Sporadic Alzheimer's Disease: Society for Neurosciences
2003-Chlamydia pneumoniae Infection: A Trigger for Alzheimer’s disease: Lankenau Institute for Medical Research
2005-Neuropathological entities of Alzheimer's Disease are triggered following infection of neuronal cells with Chlamydophila (Chlamydia) pneumoniae" Drexel University Medical School
2008- Think Tank on Dementia: Eastern Pennsylvania Geriatrics Society
2008- Current Hypotheses of Alzheimer’s Disease: Should We Be Looking Outside The Box?: AOA
2009-The Pathogen Hypothesis in Alzheimer’s Disease: MidWestern Osteopathic School
CCDA (7/1/2013 -6/30/2014) Co-PI: Bactericidal Implant Surfaces
Rose and Adolf Levis Foundation (1/01/2003-present) Co-PI; Chlamydia pneumoniae’s role in the pathogenesis of sporadic Alzheimer’s disease
CCDA (7/1/2012 -6/30/2013) Co-PI; Infection with Chlamydia Pneumoniae alters calcium-associated gene regulations and processes in neuronal cells and monocytes: Implications for Alzheimer’s disease
CCDA (7/1/2012 -6/30/2013) Co-PI; Detection of Chlamydia pneumoniae in blood samples: A diagnostic screen for Alzheimer’s disease
CCDA (9/1/2011 -6/30/2012) PI; Analysis by Real-Time PCR of Autophagy and Apoptosis in Neuronal Cells Infected with Chlamydia Pneumoniae
Health Research Formula Fund :(1/01/ 2009- 12/31/2013) PI; Dissecting the apoptosis pathway affected by C. pneumoniae in Alzheimer's disease
CCDA (9/1/2008 -6/30/2009) PI; Chlamydophila (Chlamydia) pneumoniae (Cpn) promotes Aβ 1-42 amyloid processing in Neuronal Cells: A Pathogenic Trigger for Alzheimer’s disease
CCDA (10/1/2007 -9/30/2008) PI; Effects on the apoptotic markers following a Chlamydial infection in neurons and astrocytes: Implications for Alzheimer’s disease
Alzheimer Association 7/01/04 to 6/30/07) Co-investigator; Chlamydia pneumoniae infection of Mice triggers Alzheimer-like pathology
NIH R01ES006478-09A2 (7/2003-2008) Collaborator; Mechanisms of Cadmium Toxicity in Epithelial Cells NIH/NIAID - R01- AI44055-01A1 (06/01/99 - 05/31/04). Co-investigator; Chlamydia pneumoniae: a pathogen in Alzheimer’s disease?
NIH/R15: (5/01/01-06/30/03) Co-investigator; Immunosenescence and Chlamydia Pneumoniae” Foundation for Research into the Diseases of Aging (6/01/99-7/01/2003) Co-investigator; Investigation of Chlamydia pneumoniae in Diseases of the Aging
National Foundation for Infectious Diseases(6/01/99-7/01/2000)PI; Pathologic manifestations induced by Chlamydia Pneumonia infected glial cells in AD