CHRISTOPHER S. ADAMS, PHD
Department of Bio-Medical Sciences - Philadelphia
Professor of Anatomy


Christopher S. Adams, PhD

Contact

Email: christopherad@pcom.edu
Office: 215-871-6534

Dr. Adams is a professor of anatomy with the Department of Bio-Medical Sciences.

  • Education

    Post-Doc, Biochemistry, University of Pennsylvania, 1998-2001
    Post-Doc, Biochemistry, Laboratory of Biological Chemistry, NIA, NIH, 1996-1998
    PhD, Biomedical Science, Kent State University, 1996
    MA, Anthropology, Kent State University, 1991
    BS, Biology, Antioch College, 1987

  • Awards

    1996-1998 Intramural Research Training Award Fellowship, National Institute on Aging, NIH

    1997 Glenn Foundation Award presented at the 1997 ASCB Annual Meeting, Washington DC, December 15, 1997.

    2001-2004 Individual National Research Service Award, NIDCR, NIH.

    2001 New Investigator Award, 7th International Conference on the Chemistry and Biology of Mineralized Tissues, November 8, 2001

    2001 - present Member of American Society for Bone and Mineral Research

    2004 - 2005 Member of American Society for Biochemistry and Molecular Biology

    2009 - present Member of the Orthopaedic Research Society

    2012 – present Member of the American Association of Anatomists

  • Publications

    Selected publications:

    Published papers (peer-reviewed)

    Adams, CS, Antoci, V Jr, Harrison, G, Patal, P, Freeman, TA, Shapiro, IM, Parvizi, J, Hickock, NJ, Radin, S, Ducheyne, P: Controlled Release of Vancomycin from Thin Sol-Gel Films on Implant Surfaces Successfully Inhibits Osteomyelitis. Journal of Orthopaedic Research, 27:701-709, 2009.

    Gilbert, JR, Adams, CS, Shapiro, IM, Hickok, NJ: A Novel Short Hairpin RNA (shRNA) Expression System Promotes SOX9-Dependent Gene Silencing. Plasmid. 62(1):50-55, 2009.

    Ketonis, C, Aiyer, A, Adams, CS, Shapiro, IM, Hickok, NJ, Parvizi, J.: Bacterial Colonization of Bone Allografts: Establishment and Effects of Antibiotics. Current Orthopaedics and Related Research, 468:2113-2121, 2010.

    Ketonis, C, Aiyer, A, Adams, CS, Barr, S, Shapiro, IM, Parvizi, J, Hickok, NJ: Antibiotic modification of native grafts: Improving upon Nature's scaffolds. Tissue Engineering, 16(6): 2041-2049, 2010.

    Zahm, A, Bucaro MA, Ayyaswamy, PS, Srinivas, V, Shapiro, IM, Adams, CS, Mukundakrishnan, K: Numerical Modeling of Oxygen Distributions in Cortical and Cancellous Bone: Oxygen Availability Governs Osteonal and Trabecular Dimensions. American Journal of Physiology 299:C922-C929, 2010.

    Ketonis, C, Barr, S, Shapiro, IM, Parvizi, J, Adams, CS, Hickok, NJ: Anti-bacterial Activity of Bone Allografts: Comparison of a New Vancomycin-tethered Allograft with Allograft loaded with adsorbed Vancomycin. Bone, 48:631-638, 2011.

    Ketonis, C., Barr, S., Adams, CS, Shapiro, IM, Parvizi, J., Hickok, NJ: Vancomycin bonded to bone grafts prevents bacterial colonization. Antimicrobials and Chemotherapeutics, 55(2):487-494, 2011.

    Zahm, A., Adams, C.S., Shapiro, I.M., Srinivas, V.: Osteocytic Differentiation from the osteoblastic state is marked by an increase in autophagy. Cells Tissue Organs, 194(2-4):274-278, 2011.

    Books and Chapters

    Adams, C.S., Horton, W.E.: Apoptosis and Bone Disease. In: Programmed Cell Death Volume II: Role in Disease, Pathogenesis and Prevention (M.Matson, S. Estus, V. Rannekar, Eds.): 277-313, 2001.

    Adams, C.S, Mansfield, K.D., Rajpurohit, R., Tachibana, H., Teixeira, C.M., Shapiro, I.M.: Components of Extracellular Matrix Regulate Chondrocyte Apoptosis. In: Growth Plate 2001: Proceedings of the First International Conference on the Growth Plate (Shapiro, I.M., Boyan, B.D., Anderson, H.C., eds.): 63-76, Amsterdam: IOS Press, 2002.

    Shapiro, I.M., Adams, C.S., Freeman, T., and Srinivas, V.: The fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Research Part C: Embryo Today: Reviews. 75(4): 330-339, 2005.

    Shapiro, IM, Adams, CS, Srinivas, V, and Freeman, TA.: Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface. In: Bone and Osteoarthritis (Topics in Bone Biology Vol 4)(F. Bronner and M.C. Farach-Carson, eds.) Springer-Verlag: London pp. 109-129, 2007.

    Hickok, NJ, Ketonis, C, Adams, CS: Tethered Antibiotics. In: Comprehensive Biomaterials, Vol. 4 Surface Engineering (Ducheyne, P, Healy, K.E., Hutmacher, D.W., Grainger, D.W., Kirkpatrick, C.J., eds.), 4: 281-294, 2011.

    Adams, CS, Biomaterials. In: Total Hip Arthroplasy: The Essentials (Parvizi, J, ed.) 2013.

  • Grants

    Completed

    05/01/02 - 04/30/04 NIH/NIDCR Regulation of Apoptosis in Osteoblast-like Cells (PI: Adams), Role: PI

    12/01/03 - 11/30/07 USA Med Research Acq Activity Orthopaedic Implants Engineered to Prevent Post-Operative Infection of Open Fractures (PI: Shapiro), Role: Co-I.

    03/01/94 - 03/31/07 NIH/NIDCR Bone Growth in Dental, Cranial and Skeletal Tissues (PI: Shapiro), Role: Co-I.

    12/01/04 - 11/30/09 NIH Oxygen Sensing and Growth Plate Chondrocyte Maturation (PI: Srinivas), Role: Co-I.

    01/01/05 - 12/31/09 NIH Smart Substrates for a New Generation of Implants (PI: Shapiro), Role: Co-I

    01/01/05 - 12/31/06 Commonwealth of Pennsylvania Designing a new generation of implants: tethering bioactive molecules to prosthetic devices (PI: Adams), Role: PI

    07/01/10 - 06/31/11 CCDA Effect of Liposuction Technique on the viability and differentiation of adipose derived Stem cells (PI: Adams), Role: PI

    07/01/11 - 06/31/12 CCDA Effect of Liposuction Technique on the viability and differentiation of adipose derived Stem cells (PI: D’Angelo), Role: Co-I

    07/01/11 - 06/30/12 CCDA The Role of Osteoblast Maturation in the Regulation of Calcium and Phosphate Ion Pair-Induced Apoptosis (PI: Adams) Role: PI.

    09/17/09 – 08/31/12 NIH/NIDCR A New Allograft that promotes Long-Term, Infection-Free Skeletal Repair (MPI:Hickok and Adams) Role: MPI.

    07/01/12 - 06/30/13 CCDA The Role of Osteoblast Maturation in the Regulation of Calcium and Phosphate Ion Pair-Induced Apoptosis (PI: Adams) Role: PI.

    Current

    08/10/09 – 07/31/14 NIH/NICHD Creating an Infection-free Intraosseus Transcutaneous Amputation Prosthesis (MPI:Hickok and Adams) Role: MPI.

    07/01/13 - 06/30/14 CCDA Bactericidal Implant Surfaces (PI: Adams) Role: PI.