First select the set to limit by clicking in the Select button for the set. In this case we want to limit set #6. Then scroll down the page to find the other limits to apply.

Select	#	Search History	Results
	1	exp anemia, sickle cell/	9836
	2	exp penicillins/	43275
	3	1 and 2	98
	4	(prevent$ or prophyla$).tw.	359624
	5	3 and 4	45
	6	limit 5 to (human and english language)	45

Limit to:

Human	English Language	Review Articles
Abstracts	Full Text Available	Latest Update
Animal	Male	Female
AIM Journals	Evidence Based Medicine Reviews	All EBMR Article Reviews
Topic Reviews <Cochrane>	Article Reviews <Best Evidence>	Article Reviews <DARE>

Publication Year -19601961196219631964196519661967196819691970197119721973197419751976197719781979198019811982198319841985198619871988198919901991199219931994199519961997199819992000--20001999199819971996199519941993199219911990198919881987198619851984198319821981198019791978197719761975197419731972197119701969196819671966196519641963196219611960

Languages -AfrikaansAlbanianArabicArmenianAzerbaijaniBelorussianBengaliBulgarianBurmeseCatalanChineseCroatianCzechDanishDutchEnglishEsperantoEstonianFinnishFlemishFrenchGaelic, ScotsGeorgianGermanGreekHausaHebrewHindiHungarianIcelandicIndonesianInterlinguaItalianJapaneseKirghizKoreanLatinLatvianLithuanianMacedonianMalayMarathiMasaiMultilingualNorwegianPersianPolishPortuguesePushtoRumanianRussianSerbianSerboCroatian, CyrillicSerboCroatian, RomanSlovakSloveneSpanishSwahiliSwedishTagalogTamilTeluguThaiTurkishUkrainianUrduVietnameseWelsh	Age Groups -Newborn Infant <birth to 1 month>Infant <1 to 23 months>Preschool Child <2 to 5 years>Child <6 to 12 years>Adolescence <13 to 18 years>Adult <19 to 44 years>Middle Age <45 to 64 years>Aged <65 and Over>Aged, <80 and Over>
Scroll down the list of Publication Types to select  Clinical Trial  (this term will automatically include the phases, randomized and controlled trials). Click on Limit Search at the bottom or top of the page.
Publication Types -AddressesBibliographyBiographyClassical ArticleClinical ConferenceClinical TrialClinical Trial, Phase IClinical Trial, Phase IIClinical Trial, Phase IIIClinical Trial, Phase IVCommentCongressesConsensus Development ConferenceConsensus Development Conference, NIHControlled Clinical TrialCorrected and Republished ArticleDictionaryDirectoryDuplicate PublicationEditorialFestschriftGuidelineHistorical ArticleInterviewJournal ArticleLecturesLegal CasesLetterMeta AnalysisMonographMulticenter StudyNewsOverallPeriodical IndexPractice GuidelinePublished ErratumRandomized Controlled TrialRetracted PublicationRetraction of PublicationReviewReview LiteratureReview of Reported CasesReview, AcademicReview, MulticaseReview, TutorialTechnical ReportTwin Study	Animal Types -CatsCattleChick EmbryoDogsGoatsGuinea PigsHamstersHorsesMiceRabbitsRatsSheepSwine
Journal Subsets -AIM JournalsCancer JournalsNursing JournalsDental Journals