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Zhang, Dianzheng

Zhang, Dianzheng

Dianzheng Zhang, PhD

Associate Professor of Biochemistry and Molecular Biology
Department of Bio-Medical Sciences

Contact
Ph: 215-871-6588
FX: 215-871-6865
E-mail: dianzhengzh@pcom.edu

Education

PhD, Nutritional Science, The University of Arizona, Tucson, 2001
MS, Biochemistry, Hunan Medical University, Changsha, P. R. China, 1987
BS, Chemistry, Qufu Teaching University Qufu, Shandong, P. R. China

Narrative

Dr. Zhang teaches the following courses: Introduction to Medical Biochemistry and Molecular Biology, Medical Biochemistry and Molecular Biology, and Cellular and Molecular Basis of Medicine (CMBM). Dr. Zhang’s courses cover the following content areas: hormonal regulation of metabolisms, ATP and energy generation, dietary carbohydrate metabolism, dietary proteins, fatty acid synthesis, and lipoproteins.

Dr. Zhang’s general interest is the nutrient control of gene expression in health and disease. Particularly, he is interested in the regulation of gene expression by micronutrients, such as vitamins and minerals, as well as phytochemicals. As living organisms, we continuously exchange chemical components with the environment; the exchange nutrients are implicated in the regulation of gene expression and cell fates, which ultimately confer life or death. With increasing knowledge of the importance of nutrition in our aging population, medicine is shifting its focus from treatment of acute diseases, to the prevention of cancer and chronic diseases. It has been estimated that thirty to fifty percent of all chronic diseases are preventable by attention to dietary factors. Present research projects in his laboratory are focused on, but not limited to, the (1) molecular mechanisms of chemo-preventive effects of different phytochemicals, especially resveratrol, in prostate cancer development, (2) mechanisms of resveratrol effects on tensin expression and prostate cancer, and (3) the underlying molecular mechanisms of TMPRSS fusion with ETS transcriptional factors (ERG in particular) in cancer prevention and gene therapy.

Honors/Awards

2008 Visiting Professor: Changsha Medical College, Hunan Province, PRC

2007 Visiting Professor: Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

2006 Young Researcher Scholarship for AICR/WCRF International Research Conference on Food, Nutrition and Cancer (2006, Washington, D.C.) American Institute of Cancer Research and World cancer Research Fund International

2005 Outstanding Performance and Excellence in Scientific Presentation The 2005 Texas Chapter Annual Symposium

2003 Award for Excellent Presentation of Research Society of Chinese Biochemists in America, Texas Chapter

1990 Advanced Research Award Hunan province, P. R. China

1989 Excellent Teaching Award Hunan Medical University, P. R. China

Selected Publications

Zhifeng Ning, Jinfeng Gan, Chaoying Chen, Dianzheng Zhang, Hao Zhang (2014) Molecular functions and significance of the MTA family in hormone-independent cancer. Cancer and Metastasis Review 2014 Oct 24. [Epub ahead of print]
 
Xiaoshen Sun, Zainul S. Hasanali, Allshine Chen, Dianzheng Zhang, Xin Liu, Hong-Gang Wang, David J. Feith, Thomas P. Loughran Jr and Kailin Xu (2014) Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia. British Journal of Hematology 2014 Oct 4. doi: 10.1111/bjh.13143. [Epub ahead of print]
 
Wei Zhao, Cunjie Chang, Yangyan Cui, Xiaozhi Zhao, Jun Yang, Lan Shen, Ji Zhou, Zhibo Hou, Zhen Zhang, Changxiao Ye, Donald Hasenmayer, Robert Perkins, Xiaojing Huang, Xin Yao, Like Yu, Ruimin Huang, Dianzheng Zhang, Hongqian Guo, Jun Yan (2014) Steroid Receptor Coactivator-3 Regulates Glucose Metabolism in Bladder Cancer Cells through Coactivation of Hypoxia Inducible-Factor 1α. Journal of Biological Chemistry 2014 Apr 18; 289 (16):11219-29 (ePub ahead) 

Weihua Lan, Dianzheng Zhang, Jun Jiang (2013) The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells Medical Hypotheses Sep 8. doi:pii: S0306-9877(13)00439-8 10.1016/j.mehy.2013.09.005. [Epub ahead of print]

Xin-xing Wan, Hanchun Chen, Md. Asaduzzaman Khan, Ai-hua Xu, Fu-lan Yang, Yun-yi Zhang and Dianzheng Zhang (2013) ISG15 Inhibits IFN-α Resistant Liver Cancer Cell Growth BioMed Research International (in print)

Md. Asaduzzaman Khan, Han-chun Chen, Dianzheng Zhang, Junjiang Fu (2013) Twist: a molecular target in cancer therapeutics Tumor Biology 34 (5): 2497-2506

Fang-dan Ouyang, Fu-lan Yang, Han-chun Chen, Md. Asaduzzaman Khan, Feng-mao Huang, Xin-xing Wan, Ai-hua Xu, Xing Huang, Mei-juan Zhou, Qian Fang, Dian-zheng Zhang (2013) Polymorphisms of DNA repair genes XPD, XRCC1 and OGG1, and lung adenocarcinoma susceptibility in Chinese population Tumor Biology 34 (5):2843-8

Tang Q, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D, Dianzheng Zhang, Zhang H. (2013) Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma Cancer Letters 336 (2): 325-37

Md. Asaduzzaman Khan, Han-chun Chen, Xin-xing Wan, Mousumi Tania, Ai-hua Xu,Fang-zhi Chen, and Dian-zheng Zhang (2013) Regulatory Effects of Resveratrol on Antioxidant Enzymes: A Mechanism of Growth Inhibition and Apoptosis Induction in Cancer Cells. Molecules and Cells 35(4): 355

Feng-mao Huang, Han-chun Chen, Md. Asaduzzaman Khan, Fu-lan Yang, Xin-xing Wan, Ai-hua Xu, Fang-dan Ou-yang, Dian-zheng Zhang (2013) CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China Medical Oncology 30 (2): 521

Jia Liu, Han-chun Chen, Zhou-zhou Rao, Md. Asaduzzaman Khan, Xin-xing Wan, Ai-hua Xu, Nuo Zhang and Dian-zheng Zhang (2011) Identification of heptapeptides interacting with IFN-a-sensitive CML cells Expert Opinion on Investigational Drugs 20 (12): 1583-1589

Han-chun Chen & Hui-juan Chen & Md. Asaduzzaman Khan & Zhou-zhou Rao & Xin-xing Wan & Bo Tan and Dianzheng Zhang (2011) Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China Tumor Biology 32 (2): 367-73

Luo YP, Chen HC, Khan MA, Chen FZ, Wan XX, Tan B, Ou-Yang FD, and Zhang DZ (2011) Genetic Polymorphisms of Metabolic Enzymes- CYP1A1, CYP2D6, GSTM1, and GSTT1, and Gastric Carcinoma Susceptibility. Tumor Biology 32 (1): 215-22

Md Asaduzzaman Khan, Han-chun Chen, Mousumi Tania, and Dian-zheng Zhang (2011) Anticancer Activities of Nigella Sativa (Black Cumin). African Journal of Traditional, Complementary and Alternative medicines (AJTCAM) 8(5S): 226–232

Xin-Xing Wan, Dianzheng Zhang, and Han-Chun Chen (2010) The functions of ISG15 Ubiquitin-like Modifier and its Modifier Enzymes. Chinese Journal of Biochemistry and Molecular Biology 26 (4): 295-300

Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, and Han-chun Chen (2010) Antixodant Enzymes and Cancer. Chinese Journal of Cancer Research 22 (2):87-92

Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, and Han-chun Chen (2010) Cordyceps Mushroom: A Potent Anticancer Nutraceutical. The Open Nutraceuticals Journal 3: 179-183

Wen-feng Shi, Melanie Leong, Ellen Cho, Joseph Farrell, Han-chun Chen, Jun Tian and Dianzheng Zhang (2009) Repressive Effects of Resveratrol on Androgen Receptor Transcriptional Activity. Plos ONE 4 (10), e7398: 1-10

Melanie Leong, Wen-feng Shi, Jun Tian, Ellen Cho, Abbas Raza, Saquib A. Siddiqi, Abdulhafez Selim, Han-chun Chen, and Dianzheng Zhang (2009) Overexpression of truncated ERG from TMPRSS2-ERG fusion and Prostate Cancer Development. Pathology and Lab Medicine International 1:13-21

Jun Tian, Wen-Feng Shi, Lu-Wei Zhang, Nan Lu, Xian-Quan Cui, Wan-Hua Xian, Huai-Bin Sun, En-Gang Li, Li-Na Geng, Dianzheng Zhang, and Xiong Zou (2009) HLA Class-I (ABC) Up-Regulation on Peripheral Blood CD3+/CD8+ T-Lymphocyte Surface Is A Potential Predictor for Acute Rejection In Renal Transplant. Transplantation 88 (12): 1393–1397

Zhang, D., Cho, E. and Wong, J. (2007) A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis. Cell Research 17 (9): 804-14

Li, J., Zhang, D., Fu, J., Huang, Z. and Wong, J. (2007) Structural and functional analysis of androgen receptor in chromatin. Molecular Endocrinology

Klose RJ, Yamane K, Bae Y, Zhang, D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. (2006) The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442 (7100): 312-6

Geiser D.L., Zhang, D., Winzerling, J. J. (2006) Secreted ferritin: Mosquito defense against iron overload? Insect Biochemistry and Molecular Biology 36 (3): 177-187

Zhang, D., Yoon, H. and Wong, J. (2005) JMJD2A is a novel N-CoR interacting protein and is involved in repression of the human transcription factor Achaete Scute-Like Homologue-2 (ASCL2/HASH2). Molecular and Cellular Biology 25 (15): 6404-6414

Thompson, P. R., Wang, D., Wang, L., Fulco, M., Pediconi, N., Zhang, D., An, W., Ge Q., Roeder, R.G., Wong, J., Levrero M., Sartorelli V., Cotter R. J., Cole P.A. (2004) Regulation of the p300 HAT domain via a novel activation loop. Nature Structural and Molecular Biology 11(4): 308-415

Mayo, J., Kohlhepp, E., Zhang, D., and Winzerling, J. (2004) Effects of Sham air and cigarette smoke on A549 lung cells implications for iron-mediated oxidative damage. American Journal of Physiology: Lung Cellular and Molecular Physiology 284(4): L866-876

Zhang, D., Dimopoulos, G., Wolf, A., Minana, B., Kafatos, F., and Winzerling, J. (2002) Cloning and molecular characterization of two mosquito iron regulatory protein 1 genes. Insect Biochemistry and Molecular Biology 32 (5): 579-589

Gailer, J., George, G., Pickering, I., Prince R., Kohlhepp, P., Zhang, D., F. Walker, A. and Winzerling, J. (2001) Human cytosolic iron regulatory protein 1 contains a linear iron-sulfur cluster. Journal of American Chemical Society 123 (41): 10121-10122

Zhang, D., Albert, D., Kohlhepp P., Pham, D. Q-D., and Winzerling, J. J. (2001) Repression of Manduca sexta ferritin synthesis by IRP1/IRE interaction. Insect Molecular Biology 10(6): 531-539

Zhang, D., Ferris, C., Gailer, J., Kohlhepp, P., and Winzerling, J. (2001) Manduca sexta IRP1: Molecular characterization and in vivo response to iron. Insect Biochemistry and Molecular Biology 32 (1): 85-96

Zhang, D., (2001) Cloning, over-expression and characterization of iron regulatory protein 1 from insects. Ph.D. Dissertation. the University of Arizona

Pham, D. Q-P., Zhang, D., Hufnagel, David H., Winzerling, J. (1996) Manduca sexta hemolymph ferritin: cDNA sequence and mRNA expression. Gene, 172: 255-259

Dunkov, B., Zhang, D., Choumorov, K., Winzerling, J. and Law, J. (1995) Purification and characterization of an insect ferritin and cDNA sequence of one sub-unit. Archives of Insect Biochemistry and Physiology 29: 293-307

Regan, J., Bailey, T., Donello, J., Pierce, K., Pepperl, D., Zhang, D., Kedzie, K., Fairbarirn, C., Bogerdus, A., Woodward, D. and Gil, D. (1994) Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini. British Journal of Pharmacology 112: 377-385

Zhang, D. and Lu, Y. (1988) The first instance of variation of human erythrocyte membrane glycophorin in Chinese population. Chinese Journal of Hematology 10 (1):15-18

Zhang, D. and Lu, Y. (1988) Glycoprotein variations of human red blood cell membrane. Guo Wai Yi Xue 9 (1): 56-59

Selected Presentations

Combating prostate cancer by targeting androgen receptor with phytochemical resveratrol. BIT’s 3rd Annual World Cancer Congress-2010-Breast Cancer Congress (Fighting Breast Cancer at Molecular Level), Shanghai, P. R. China

Resveratrol, Health and Longevity (2009) Global Health Awareness Month Seminar Series, Philadelphia College of Osteopathic Medicine, Philadelphia, PA

Medical education in the United States of America (2008) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

Establishing, testing and modifying research hypothesis (2008) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

Medical education in the United States of America (2008) Changsha Medical College, Hunan Province, PRC

Molecular biological methodology in studying transcriptional regulation (2007) Department of Biochemistry, College of Medicine, Central South University, Hunan Province, PRC

Hormone receptor-targeted cancer therapy (2006) Department of Pharmaceutical Sciences, Pharmacology & Toxicology, University of the Sciences in Philadelphia, Philadelphia, PA

Transcriptional co-repressor N-CoR and erythrocyte terminal differentiation (2005) Department of Immunology, University of Texas, Houston, MD Anderson Cancer Center, Houston, TX

JMJD2A Mediated N-CoR/HDAC3 Dependent Transcriptional Repression (2005) Department of Biochemistry/Molecular Biology, Philadelphia College of Osteopathic Medicine, Philadelphia, PA

IRP/IRE Interaction and Iron Homeostasis in Insects (2002). Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Comparison of Iron Homeostasis between Insects and Mammals (2002). Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

 

Iron Regulatory Protein 1 and Iron Homeostasis in Insects (2001). Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA

Iron Homeostasis in Mammals and in Insects (2001). Department of Cancer Biology and Biochemistry, Wake Forest University of Medical Center, Winston-Salem, NC

Grants

Resveratrol, Aging and Prostate Cancer. $5000 (2006); The Center for Chronic Disorders of Aging (CCDA), Philadelphia College of Osteopathic Medicine

Effects of Resveratrol in Aging and Prostate Cancer, $15,859; 01/01/2007-21/31/2010, 2006 Formula Grant, Pennsylvania Department of Health, Bureau of Health Statistics and Research

Chromosomal Translocation-Induced Overexpression of ERG and Prostate Tumorigenesis, $15,000; 07/2008-06/2010, Christian R. Mary F. Lindback Foundation

Modification of Resveratrol and Identification of More Potent Prostate Cancer Prevention Reagents: $300,000; 6/1/2010-5/31/2013 SynStar Inc.

Research Keywords

  • Prostate cancer
  • Nutrition
  • Resveratrol
  • Androgen receptor
Last Updated: 3/19/15