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Young, Lindon

Lindon H. Young, PhD

Lindon H. Young, PhD

Professor of Pathology, Microbiology, Immunology & Forensic Medicine
Department of Bio-Medical Sciences

Contact
Ph: 215-871-6832
FX: 215-871-6869
E-mail: Lindonyo@pcom.edu

Education

PhD, Pharmacology, Philadelphia College of Pharmacy and Science, 1998
BA, Biology/Psychology, Immaculata College, 1986
AS, Hotel/Food Service Management, Pennsylvania State University, 1980

Narrative

Lindon H. Young is the director of the Pharmacology course in the Biomedical Sciences MS program and teaches in selected courses in the DO program at PCOM. Dr. Young specializes in the area of cardiovascular pharmacology and has mentored over 63 MS and DO/PhD students and four PCOM residents from 2002 to present on various research projects that range from cellular based assays to human studies. Dr. Young’s training has helped our students accomplish educational and research objectives, and continues to strive to improve the quality of teaching and mentorship to our Biomedical Sciences and DO students to pass standardized tests (e.g. Medical board exams) by having an integrative session that requires class participation via the use of the “clicker” system. Such a system enables us to immediately evaluate the classroom’s understanding of the pharmacology material. This system has proven to be effective and the classroom appears to enjoy the presentation of the material. Dr. Young has also mentored PCOM residents that have been hired as Clinical Research Associates in our myocardial I/R drug development program.

Dr. Young is a Research Investigator at PCOM who has conducted research related to myocardial ischemia-reperfusion (I/R) injury and to evaluate mechanisms related to oxidative stress that initiate I/R injury. Such research would have clinical value to heart attack and coronary bypass patients where limited pharmacological intervention is available. He received his postdoctoral training in the laboratories of Drs Margaret Weis and Allan Lefer where he conducted research related to myocardial I/R injury.

Thereafter, Dr. Young started his academic research career at PCOM in 2002. The first study was conducted using a broad-spectrum protein kinase C (PKC) inhibitor, Gö6983, which was shown to increase vascular nitric oxide (NO) release and inhibit leukocyte surperoxide (SO release). This tool served as an effective prognostic indicator for the general role of PKC regulation in I/R injury. Then he started to use selective PKC isoform inhibitors and activators that differentially regulate eNOS and NADPH oxidase activities as they relate to myocardial I/R. Subsequently, the remarkable results of PKC epsilon peptide inhibitor have led me to further explore the role of eNOS uncoupling as a key mechanism in myocardial I/R injury that transcends both rat and porcine species. PCOM has also been awarded US and worldwide patents regarding the PKC isoform peptide modulators such as PKC epsilon inhibitor. Dr. Young has collaborated with many other investigators both intra and extramurally on a wide array of research projects that range from evaluating the role of genetic markers in myocardial developmental biology to OMT-based research in patients.

Honors/Awards

2013-2014 Professor of the Year Award presented by the PCOM DO Class of 2017.

P.C.O.M. has been granted U.S. (PKC beta II peptide inhibitor, filing date: 09/28/2007; patent awarded: 08/25/2011) and European (PKC epsilon peptide inhibitor, filing date: 12/11/2006; patent awarded: 05/10/2012) patents pertaining to the development of a preservation/perfusion solution that can be used in patients with acute coronary syndromes that include but are not limited to myocardial infarction, angina, coronary bypass/angioplasty and organ transplantation. –role on patents: Inventor

1999-2001 National Heart, Lung & Blood Institute Training Grant HL-07599NHH, National Service Research Award

Selected Publications

Allan M. Prior, Man Zhang, Nina Blakeman, Palika Datta, Hung Pham, Qian Chen, Lindon H. Young, Margaret T. Weis, Duy H. Hua. Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury. Bioorganic & Medicinal Chemistry Letters 24 (4):1057-1061, 2014.

Matthew Montgomery, Jovan Adams, Jane Teng, Biruk Tekelehaymanot, Regina Ondrasik, Issachar Devine, Kerry-Anne Perkins, Qian Chen, Robert Barsotti, and Lindon H. Young. Myristoylated protein kinase C epsilon peptide inhibitor exerts cardioprotective effects in rat and porcine myocardial ischemia/reperfusion: A translational research study. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 178-179, 2013.

Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.

Alexandra C. Lopez, Qian Chen, Brittany L. Deiling, Edward S. Iames, Robert Barsotti, and Lindon H. Young. The Effects of Modulating Endothelial Nitric Oxide Synthase (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 58-59, 2013.

T. Galbreath, Q. Chen, R. Ondrasik, M. Bertolet, R. Barsotti, L. Young. Effects of Mitochondrial-Targeted Antioxidants on Real-time Nitric Oxide and Hydrogen Peroxide Release in Hind Limb Ischemia and Reperfusion (I/R). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 46-47, 2013.

Issachar Devine, Qian Chen, Regina Ondrasik, William Chau, Katelyn Navitsky, On Say Lau, Christopher W. Parker, Kyle D. Bartol, Brendan Casey, Robert Barsotti, Lindon H. Young. Cardioprotective Effects of Cell Permeable NADPH oxidase inhibitors in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 42-43, 2013.

Matthew L. Bertolet, Michael Minni, Tyler Galbreath, Robert Barsotti, Lindon H. Young, and Qian Chen. Effects of Selective NADPH Oxidase Inhibitors on Real-Time Blood Nitric Oxideand Hydrogen Peroxide Release in Acute Hyperglycemia. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 34-35, 2013.

Hung T. Pham, Robert Barsotti, Amber N. Koon, Brian Rueter, Lindon H. Young, and Qian Chen. The Role of NADPH Oxidase on L-NAME-induced Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 66-67, 2013.

Regina Ondrasik, Qian Chen, Katelyn Navitsky, William Chau, Issachar Devine, On S. Lau,Tyler Galbreath, Robert Barsotti, and Lindon H. Young. Cardioprotective Effects of Mitochondrial-Targeted Antioxidants in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 64-65, 2013.

Nina Blakeman, Qian Chen, Jasmine Tolson, Brian Rueter , Brian Diaz, Brendan Casey, Lindon H. Young, Margaret T. Weis. Triacsin C, a Fatty Acyl CoA Synthetase Inhibitor, Improves Cardiac Performance Following Global Ischemia. Am. J. Biomed. Sci., 4(3), 249-261, 2012.

Kerry-Anne A. Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S. Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Iyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng and Lindon H. Young. The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). Naunyn-Schmiedeberg’s Arch of Pharmacol 385(1):27-38, 2012.

Qian Chen, Edward Iames, Daniel Torino, Kerry-Anne Perkins, Brian Rueter, Catherine Prince, and Lindon Howard Young. The effects of Gö 6983 and selective protein kinase C beta II peptide inhibitor on local hyperglycemia-induced leukocyte-endothelial interactions. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 282-283, 2011.

Edward S. Iames, Kerry-Anne Perkins, Qian Chen, and Lindon Young. The role of protein kinase C epsilon in the regulation of endothelial nitric oxide synthase during oxidative stress caused by extracorporeal shock wave lithotripsy. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 278-279, 2011.

Kerry-Anne Perkins, Kyle Bartol, Qian Chen, Erin Feinstein, and Lindon Young. Myristoylation of protein kinase C beta II/zeta peptide inhibitors, or caveolin-1 peptide facilitates rapid attenuation of phorbol 12-myristate 13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) activated leukocyte superoxide release. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 288-289, 2011.

Maria A. Kern, Lindon H. Young, Edward S. Iames, and Qian Chen. The effects of protein kinase C epsilon peptide regulation on endothelial nitric oxide synthase (eNOS) uncoupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 286-287, 2011.

Kyle Bartol, Kerry-Anne Perkins, Qian Chen, Lindon Young. Effects of a selective protein kinase C beta II peptide inhibitor on real-time blood nitric oxide and hydrogen peroxide release in femoral artery/vein ischemia and reperfusion. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 284-285, 2011.

Michael Minni, Qian Chen, Kyle Bartol, Edward Iames, Maria Kern, Kerry-Anne Perkins, Brian Rueter, Lindon Howard Young. Effects of protein kinase C selective beta II peptide inhibitor on real-time blood nitric oxide and hydrogen peroxide release under acute hyperglycemia. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 280-281, 2011.

Chen Q, Rueter B, Krass S, Zambrano C, Thomas S, Prince C, Bell B, Chai V, Emrich J, Young L. The potential clinical application of protein kinase C beta II peptide inhibitor and Gö 6983 in vascular endothelial dysfunction. Current Topics in Pharmacol 14:11-24, 2010

Guo D, Young L, Wu Y, Belardinelli L, Kowey PR, Yan GX. Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias. Am J Physiol Heart Circ Physiol 298: H1375-1381, 2010

Chen Q, Kim EJ, Elio K, Zambrano C, Krass S, Teng J, Kay H, Perkins KA, Pershad S, McGraw S, Emrich J, Adams JS, Young L. The role of tetrahydorbiopterin and dihydrobiopterin in ischemia/reperfusion injury when given at reperfusion. Adv in Pharmacol Sci 2010: 963914, 2010.

Guo D, Young L, Patel C, Jiao Z, Wu Y, Liu T, Kowey PR, Yan GX. Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit. Am J Physiol Heart Circ Physiol 295: H97-109, 2008

Teng JC, Kay H, Chen Q, Adams J, Zambrano C, Krass S, Grilli C, Guglielmello G, Bell A, Young LH. Mechanisms related to cardioprotective effects of protein Kinase C epsilon peptide activator (PKC Ɛ+) and inhibitor (PKC Ɛ-) in rat ischemia/reperfusion injury. Naunyn-Schmiedeberg’s Archives of Pharmacology 378(1):1-15 2008.

Young LH, Phillipson A, Omiyi D, Atkinson N, Jivani M, Adams J, Peterman EE, Taormina PII, Brue RJ and Harvey M. Protein kinase C (PKC) isoform peptide activator/inhibitors exert cardioprotective effects in polymorphonuclear leukocyte (PMN)-induced ischemia/reperfusion (I/R) injury. Understanding Biology Using Peptides, Proceedings of the 19th American Peptide Symposium SE Blondelle, Editor 457-458 (2006).

Young LH, Balin BJ and Weis MT. Gö 6983: A fast acting Protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev 23: 262-279, 2005.

Omiyi D, Brue R, Taormina P, Harvey M, Atkinson NK and Young, LH. Protein kinase C beta II (PKC-βII) peptide inhibitor exerts cardioprotection in polymorphonuclear leukocyte (PMNs) induced ischemia/reperfusion (I/R) injury. J Pharmacol Exp Thera 314: 542-551, 2005.

Phillipson A, Peterman EE, Taormina II P, Harvey M, Brue RJ, Atkinson N, Omiyi D, Chukwu U and Young LH. Protein kinase C zeta inhibition exerts cardioprotective effects in ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 289: H898-H907, 2005.

Weis MT, Crumley JL, Young LH and Stallone JN. Inhibiting long chain fatty acyl Co A synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardiovasc Res 63: 338-46, 2004.

Peterman EE, Taormina II P, Harvey M and Young LH. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43: 645-656, 2004.

Ikeda, Y., Young, L.H. and Lefer, A.M. Rosuvastain, a new HMG-CoA reductase inhibitor, protects the ischemic reperfused myocardium in normochoesterolemic rats. Journal of Cardiovascular Pharmacology 41: 649-655, 2003.

Young, L.H., Berchute, A. and Weis, M.T. Mg2+ efflux from the isolated perfused rabbit heart is mediated by two states of the β1 -adrenergic receptor. Naunyn-Schmiedeberg’s Archives of Pharmacology 366: 431-439, 2002.

Ikeda, Y., Young, L.H. and Lefer, A.M. Attenuation of neutrophil mediated myocardial ischemia reperfusion injury by a calpain inhibitor. American Journal of Physiology 282: H1421-H1426, 2002.

Ikeda, Y., Young, L.H., Vournakis, J.N. and Lefer, A.M. Vascular effects of poly N acetyl glucosamine in isolated rat aortic rings. Journal of Surgical Research 102: 215-220, 2002.

Young, L.H., Ikeda, Y. and Lefer, A.M. Caveolin-1 exerts cardioprotective effects in myocardial ischemia/reperfusion via a nitric oxide mechanism. American Journal of Physiology 280: H2489-H2495, 2001.

Young, L.H., Ikeda, Y. and Lefer, A.M. PKC inhibition exerts cardioprotective effects in myocardial ischemia/reperfusion injury via inhibition of superoxide release. Methods and Findings in Experimental and Clinical Pharmacology 23: 107-114, 2001.

Ikeda, Y., Young, L.H., Ross, C.R. and Lefer, A.M. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia/reperfusion. Cardiovascular Research 49: 69-77, 2001.

Young, L.H., Ikeda, Y., Scalia, R. and Lefer, A.M. C-peptide exerts cardioprotective effects in myocardial ischemia/reperfusion. American Journal of Physiology 279: H1 453-459, 2000.

Young, L.H., Ikeda, Y., Scalia, R. and Lefer, A.M. Wortmannin, a potent anti-neutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion. Journal of Experimental Pharmacology and Therapeutics 295: 37-43, 2000.

Ikeda, Y., Young, L.H., Scalia, R. and Lefer, A.M. Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-NO mediated mechanism. Methods and Findings in Experimental and Clinical Pharmacology 22: 563-571, 2000.

Yang, X., Young, L.H. and Voigt, J.M. Expression of a vitamin D-regulated gene (VDUP-1) in untreated rat mammary tissue and MNU-treated rat mammary tumors. Breast Cancer Research and Treatment, 48: 33-44, 1998.

Young, L.H., Yang, X., and Voigt, J.M. Alteration of gene expression in rat mammary tumors induced by N-methyl-N-nitrosourea. Molecular Carcinogenesis, 15: 251-260, 1996.

Cohen, J.A., Baggott, L.A., Romano C., Arai M., Southerling, T.E., Young, L.H., Kozak, C.A., Molinoff, P.B., and Greene, M.I. Characterization of a mouse beta 1-adrenergic receptor genomic clone. DNA and Cell Biology, 12: 537-547, 1993.

Cohen, J.A., Arai, M., Prak, E.L., Brooks, S.A., Young, L.H. and Prystowsky, M.B. Characterization of a novel mRNA expressed by neurons in mature brain. Journal of Neuroscience Research, 31: 273-284, 1992.

Dousset V., Grossman, R.I., Ramer, K.N., Schall, M.D., Young, L.H., Gonzalez-Scarano F., Lavi, E., and Cohen, J.A. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology, 182: 483-491, 1992.

Selected Presentations

Lindon H. Young, Christopher W. Parker, Robert Barsotti, Kyle D. Bartol, Tsion Habamu, Jasmine Tolson, Deima Koko, Brian Diaz, Brendan Casey, Regina Ondrasik, Qian Chen , Justin Miller, Amanda Miller, Jaclyn Milici. Apocynin exerts dose-dependent cardioprotective effects by attenuating reactive oxygen species (ROS) in ischemia/reperfusion (I/R). Federation of American Societies for Experimental Biology, 27: 1191.1, 2013.

Brittany L. Deiling, Edward S. Iames, Kerry-Anne Perkins, Qian Chen, Lindon H. Young. Tetrahydrobiopterin attenuates extracorporeal shock wave lithrotripsy-induced blood nitric oxide level reduction in the renal vein. Federation of American Societies for Experimental Biology, 26: 1137.5, 2012.

Kyle D. Bartol, Tsion Habtamu, Jasmine Tolson, Deima Koko, Brian Diaz, Ryan Murphy, Qian Chen and Lindon H. Young. Apocynin exerts cardioprotection in ischemia-reperfusion by inhibiting superoxide release from NADPH oxidase. Federation of American Societies for Experimental Biology, 26: 1136.16, 2012.

Margaret T. Weis, Jasmine Tolson, Qian Chen and Lindon H. Young. Triacsin C, a fatty acyl CoA synthetase inhibitor, improves cardiac performance following global ischemia. Federation of American Societies for Experimental Biology, 26: 1136.18, 2012.

Christopher W. Parker, Kyle D. Bartol, Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Effects of NADPH oxidase inhibitor apocynin on real-time blood hydrogen peroxide release in femoral artery/vein ischemia and reperfusion. Federation of American Societies for Experimental Biology, 26: 678.8, 2012.

Amber Koon, Maria Kern, Lindon H. Young, Brian Rueter, Edward Iames and Qian Chen. The effects of modulating eNOS activity and coupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Federation of American Societies for Experimental Biology, 26: 680.12, 2012.

Maria A. Kern, Lindon H. Young, Brian Rueter, Edward S. Iames, Qian Chen. The role of endothelial nitric oxide synthase (eNOS) uncoupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Federation of American Societies for Experimental Biology, 25: 638.4, 2011.

Kyle D. Bartol, Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Effects of protein knase C broad spectrum inhibitor Gö 6983 on real-time blood nitric oxide and hydrogen peroxide release in femoral artery/vein ischemia and reperfusion. Federation of American Societies for Experimental Biology, 25: 639.4, 2011.

Edward S. Iames Kerry-Anne Perkins, Qian Chen and Lindon H. Young. Real-time measurement of free radicals in renal veins from exposure to extracorporeal shock wave lithotripsy treatment. Federation of American Societies for Experimental Biology, 25: 667.10, 2011.

Michael Minni, Qian Chen, Kyle Bartol, Kerry-Anne Perkins, Brian Rueter and Lindon H. Young. The real-time measurements of blood nitric oxide and hydrogen peroxide levels under acute hyperglycemia. Federation of American Societies for Experimental Biology, 25: 821.21, 2011.

Nina Blakeman, Qian Chen, Lindon Young and Margaret Weis. Evidence that fatty acyl CoA synthetase is a mediator of ischemia/reperfusion injury in the rat. Federation of American Societies for Experimental Biology, 25: 821.32, 2011.

Kerry-Anne A. Perkins, Christopher Zambrano, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan Adams, Lindon Howard Young. The roles of protein kinase C (PKC) epsilon and tetrahydrobiopterin (BH4)/dihydrobiopterin (BH2) related to endothelial nitric oxide synthase (eNOS) coupling/uncoupling in ischemia/reperfusion (I/R). Federation of American Societies for Experimental Biology, 24: 591.12, 2010.

Qian Chen, Edward S. Iames , Daniel Torino, Kerry-Anne A. Perkins, Brian Rueter, Catherine Prince, Lindon H. Young. Inhibtion of protein kinase C beta II attenuates local hyperglycemia-induced leukocyte-endothelial interactions. Federation of American Societies for Experimental Biology, 24: 590.12, 2010.

Young LH, Hodge LM, Huff J, Schander A, Downey F, Williams Jr. A, Jasti D, Linda Howard L, Kuchera ML. The Effects of Lymphatic Pump on Nitric Oxide (NO) Release by Real-time Measurement in Lymphatic Thoracic Duct and Venous Blood and Nitrite Release in Venous Blood. 15th FIMM International Scientific Conference Manuelle Medizin 48: 370, 2010.

Chen Q., Rueter B., Young L.H.. The attenuation of leukocyte-endothelial interactions by a unique broad-spectrum protein kinase C inhibitor (Gö 6983) in rat mesenteric postcapillary venules. Federation of American Societies for Experimental Biology, 23: 762.7, 2009.

Rueter B., Chen Q., Young L.H.. Inhibition of protein kinase C beta II attenuates leukocyte-endothelial interactions during acute endothelial dysfunction. Federation of American Societies for Experimental Biology, 23: 762.9, 2009.

Zambrano C., Krass S., Chen Q., Perkins K-A., Rueter B.M., Young L.H.. Real time measurement of hydrogen peroxide (H2O2) or nitric oxide (NO) in femoral ischemia/reperfusion (I/R): Effects of protein kinase C (PKC) epsilon activator (Ɛ+) or inhibitor (Ɛ-) combined with tetrahydrobiopterin (BH4) or dihydrobiopterin (BH2). Federation of American Societies for Experimental Biology, 23: 617.19, 2009.

Perkins K-A., Pershad S., Chen Q., McGraw S., Adams J., Young L.H.. Mechanisms related to endothelial nitric oxide synthase (eNOS) uncoupling in myocardial ischemia/reperfusion (MI/R). Federation of American Societies for Experimental Biology, 23: 793.13, 2009.

Chen Q, Kay H, Teng J, Burkhart S, Zambrano C, Krass S, Adams J, Grilli C, Guglielmello G, Brue R, Young LH. The mechanisms related to the cardioprotective effects of protein kinase C epsilon (PKC Ɛ-) peptide inhibitor in ischemia/reperfusion (I/R) injury when given at reperfusion. Federation of American Societies for Experimental Biology,22: 730.27, 2008.

Zambrano C., Krass S., Chen Q., Young LH. Real time measurement of hydrogen peroxide (H2O2) and nitric oxide (NO) release in femoral vein ischemia and reperfusion (I/R): The effects of tetrahydrobiopterin (BH4) dihydrobiopterin (BH2) and the effects of Protein Kinase C (PKC) epsilon activation (Ɛ+)/epsilon inhibition (Ɛ-). Federation of American Societies for Experimental Biology, 22: 730.1, 2008.

Pershad S.R., Chen Q., McGraw S., Adams J., Burkhart S., Young LH.. The combination of protein kinase C epsilon activator (PKC Ɛ+) and tetrahydrobiopterin (BH4) exerts cardioprotective effects in ischemia/reperfusion injury when given during reperfusion. Federation of American Societies for Experimental Biology, 22: 730.22, 2008.

Krass S., Zambrano C., Thomas S., Chen Q., Young LH. Real time measurement of hydrogen peroxide (H2O2) and nitric oxide (NO) release in the renal vein: The effects of Protein Kinase C beta II inhibitor (PKC β-) on rat kidneys exposed to extracorporeal shock wave lithotripsy (ESWL). Federation of American Societies for Experimental Biology, 22: 1160.8, 2008.

Thomas S., Ginsberg PC., Young LH., Krass S., Zambrano C. Administration of protein kinase C beta II inhibitor during extracorporeal shock wave lithotripsy reduces free radical production. Journal of Urology, 179(4), supplement, page 498, 2008.

Chen Q.,Wood JJ. and Young, L.H. The Effects of Tetrahydrobiopterin (BH4) and Dihydrobiopterin (BH2) on Nitric Oxide (NO) and Hydrogen Peroxide (H2O2) Release during Femoral Vein Ischemia/Reperfusion (I/R) by Real-time Measurement. Annual AOA Research Conference, 107(8):B16, 2007.

Kay, H., Teng, J.C., Adams, J.S., Atkinson, N., Grilli, C., Guglielmello, G., Brue. R., Bell, A., Dawley, M., Omiyi, D., Taormina II, P., Chen Q., and Young, L.H. Protein kinase C (PKC) isoform peptide activators (+)/inhibitors (-) attenuates polymorphonuclear leukocyte (PMN)-induced myocardial ischemia/reperfusion (MI/R) injury. Annual AOA Research Conference, 107(8):B11, 2007.

Kim, E.J., Elio, K., Chen, Q., Kay, H., Adams, J.S., Young, L.H. Tetrahydrobiopterine (BH4) exerts cardioprotective effects in ischemia/reperfusion injury when given at reperfusion. Federation of American Societies for Experimental Biology, 21: 869.16, 2007.

Elio, K., Kim, E.J., Chen, Q., Kay, H., Adams, J.S., Young, L.H. Tetrahydrobiopterine (BH4) attenuates neutrophil adhesion/transmigration in myocardial ischemia/reperfusion injury. Federation of American Societies for Experimental Biology, 21: 869.17, 2007.

Kay HY, Teng J, Adams J, Grilli C, Guglielmello G, Brue RJ, Chen Q, Bell A, and Young LH. Protein kinase C epsilon (PKC Ɛ-) peptide inhibitor exerts cardioprotective effects in ischemia/reperfusion injury when given at reperfusion. Federation of American Societies for Experimental Biology, 20 (5): #213.1, 2006.

Teng J, Adams J, Kay HY, Grilli C, Guglielmello G, Brue RJ, Chen Q, Bell A, and Young LH. Protein kinase C epsilon (PKC Ɛ+) peptide activator exerts cardioprotective effects in ischemia/reperfusion injury when given prior to ischemia. Federation of American Societies for Experimental Biology, 20 (5): #735.15, 2006.

Young LH, Phillipson A, Omiyi D, Atkinson N, Jivani M, Adams J, Peterman EE, Taormina PII, Brue RJ and Harvey M. Protein kinase C (PKC) isoform peptide activator/inhibitors exert cardioprotective effects in polymorphonuclear leukocyte (PMN)-induced ischemia/reperfusion (I/R) injury. Peptide Science, 80 (4): #P243, 2005.

Adams JS, Jivani MA, Dawley M, Hart M, Okewole S and Young LH. Protein kinase C delta (PKC δ-) peptide inhibitor exerts cardioprotective effects in ischemia/reperfusion (I/R) injury. Federation of American Societies for Experimental Biology, 19 (6): #276, 2005.

Jivani MA, Adams JS, Dawley M, Hart M, Okewole S and Young LH. Protein kinase C delta (PKC δ+) peptide activator exerts cardioprotective effects in ischemia/reperfusion (I/R) injury. Federation of American Societies for Experimental Biology, 19 (6): #281.1, 2005.

Atkinson, NK, Taormina, P, Omiyi D and Young LH. Protein kinase C beta II and zeta (PKC-βII and PKC-ζ) peptide inhibitors exert cardioprotection in polymorphonuclear leukocyte (PMNs) induced ischemia/reperfusion (I/R) injury. Federation of American Societies for Experimental Biology, 18 (5): #831.15, 2004.

Omiyi D, Brue R, Taormina P, Harvey M, Atkinson NK and Young, LH. Protein kinase C beta II (PKC-βII) peptide inhibitor exerts cardioprotection in polymorphonuclear leukocyte (PMNs) induced ischemia/reperfusion (I/R) injury. Federation of American Societies for Experimental Biology, 18 (5): #831.16, 2004.

Phillipson, A., Peterman, E.E., Taormina, P., Harvey, M. and Young, L.H. Inhibition of protein kinase C zeta inhibits superoxide release from phorbol 12-myristate-13-acetate stimulated polymorphonuclear neutrophils (PMNs). Federation of American Societies for Experimental Biology, Late Breaking Abstracts: #LB059, 2003.

Peterman, E.E., Taormina, P. and Young, L.H. Gö 6983 exerts cardioprotection in ischemia/reperfusion (I/R) by inhibiting superoxide release from polymorphonuclear neutrophils (PMNs). Federation of American Societies for Experimental Biology, 17 (4): #4541, 2003.

Young, L.H., Ikeda, Y. and Lefer, A.M. Caveolin-1 exerts cardioprotective effects in ischemia/reperfusion (I/R) via a nitric oxide mechanism. Experimental Biology 2001, Orlando, FL March 31-April 4, 2001.

Young, L.H., Ikeda, Y., Scalia, R. and Lefer, A.M. Cardioprotective effects of wortmannin via a new cellular mechanism. Circulation 102 (Suppl.): II – 205, 2000.

Young, L.H., Ikeda, Y., Scalia, R. and Lefer. C-Peptide exerts cardioprotective effects in ischemia/reperfusion. Federation of American Societies for Experimental Biology, 14 (4): # 4.4, 2000.

Weis, M.T., Berchute, A. and Young, L.H. β Adrenergic receptor (βAR) subtypes (s) and Mg2+ efflux from the isolated perfused rabbit heart. Federation of American Societies for Experimental Biology, 12 (1): #2390, 1998.

Young, L.H., Yang, X. and Voigt, J.M. In situ hybridization analysis of calcyclin and endogenous retrovirus in N-methyl-N-nitrosourea (MNU) induced rat mammary tumors. Proceedings of the American Association for Cancer Research, 38: #3742, 1997.

Young, L.H. and Voigt, J.M. Calcyclin and endogenous retrovirus expression in N-methyl-N-nitrosourea (MNU) induced rat mammary tumors. Proceedings of the American Association for Cancer Research, 37: 518, 1996.

Young, L.H. and Voigt, J.M. Analysis of gene expression in N-methyl-N-nitrosourea induced rat mammary tumors by subtractive hybridization. Proceedings of the American Association for Cancer Research, 36: 525, 1995.

Volunteer & Leadership

Journal of Renin-Angiotensin-Aldosterone-System (2012-present)

Journal of Cellular Physiology (2007-present)

Journal of Pharmacology and Experimental Therapeutics (2005-present)

Biochemica et Biophysica Acta-Proteins and Proteomics (2004-present)

British Journal of Pharmacology (2004-present)

Grants

Pennsylvania State Tobacco Grant 01/01/2012-12/31/2015
Title: Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues
Role on Project: Principal Investigator

In vivo and ex vivo mechanisms related to eNOS uncoupling during Reperfusion (Funded by the National, Heart, Lung and Blood Institute of the NIH from 4/1/08 – 3/31/11 # 2 R15 HL076235-02): SFS RR4 to the NIH
Role on Project: Principal Investigator

Center for Chronic Disorders of Aging (CCDA) at PCOM Lindon Young, Ph D (PI) 01/01/2009-10/31/2010 Tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2) in leukocyte-endothelium interactions by using intravital microscopy

Center for Chronic Disorders of Aging at PCOM Lindon Young, PhD (PI) 1/1/2008 12/31/2008 Administration of Protein Kinase C Beta II Inhibitor During Extracorporeal Shock Wave Lithotripsy Reduces Free Radical Production
Role on Project: PI

Protein Kinase C isoform inhibition in cardiac ischemia/reperfusion (Funded by the National, Heart, Lung and Blood Institute of the NIH from 3/18/04 – 2/28/07 # 1 R15 HL076235
Role on Project: Principal Investigator at P.C.O.M

Proposed role of endothelial long chain fatty acyl CoA synthetase in the development of post-menopausal hypertension (Funded by Women’s Health Research Institute, Texas Tech University Health Sciences Center (TTUHSC) at Amarillo from 4/2004 – 3/2006)
Role on Project: Co-Principal Investigator with Margaret T. Weis (TTUHSC)

Research Keywords

  • Myocardial ischemia/reperfusion injury
  • Endothelial nitric oxide synthase
  • Hydrogen peroxide
  • Nitric oxide
  • Vascular endothelial dysfunction
  • Leukocyte-endothelial interactions
  • Hyperglycemia
  • Inflammation
  • Oxidative stress
Last Updated: 3/19/15