Susan T. Hingley, PhD
Professor of Pathology, Microbiology, Immunology & Forensic Medicine
Department of Bio-Medical Sciences
Postdoctoral fellowship, Microbiology, Hahnemann University School of Medicine
Postdoctoral fellowship, Virology, University of Pennsylvania School of Medicine
PhD, Microbiology, Temple University School of Medicine, 1987
Dr. Hingley is a Professor with the Department of Biomedical Sciences. She teaches
basic science lectures in Virology, Microbiology and Mycology for the DO program and
the Masters in Biomedical Sciences Program. Dr. Hingley is co-course director for
the Reproductive Genitourinary and Obstetrics/Gynecologic Sciences (RGU/OB-GYN) course
in the DO program. In addition, Dr. Hingley has developed case scenario exercises
to supplement Microbiology lecture material for the DO program. This material is delivered
via small group discussion or using either an audience response system or as a jeopardy
Dr. Hingley is involved in two distinct research projects. The first project investigates
entry of mouse hepatitis virus (MHV) into host cells. The primary strain of MHV used
in these studies has tropism for the central nervous system and is typically studied
as an animal model for demyelinating diseases such as Multiple Sclerosis. Her work
focuses on the role of the viral fusion glycoprotein in mediating viral entry.
The second research project is a collaborative study with Drs. Appelt, Little and
Balin that examines a possible role for infectious agents in triggering Alzheimer's
Disease. Dr. Hingley’s primary involvement is in a project that investigates the effect
on autophagy of infection with Chlamydia pneumoniae or Herpes simplex virus. In addition, Dr. Hingley is interested the ability of one
pathogen to enhance or inhibit infectivity of the second pathogen in cells co-infected
with both Chlamydia pneumoniae and Herpes simplex virus. Dr. Hingley also participates in an investigation that
uses an animal model to assess the ability of Chlamydia pneumoniae to spread and cause Alzheimer’s disease-like pathology in the brains of infected
Balin, B.J., Hammond, C.J., Little, C.S., Appelt, D.M., Hingley, S.T.: Evidence for an Infectious Etiology in Alzheimer’s disease. In: Advanced Understanding
of Neurodegenerative Diseases, Raymond Chuen-Chung Chang (Ed.), ISBN: 978-953-307-529-7,
Intech, Rijeka, Croatia, 2011.
Das Sarma, J., L. C. Kenyon, S. T. Hingley, and K. S.Shindler . 2009. Mechanisms of primary axonal damage in a viral model of
multiple sclerosis. J. Neurosci. 29:10272-10280
Shindler, K. S., L. C. Kenyon, M. Dutt, S. T. Hingley, and J. D. Sarma. 2008. Experimental optic neuritis induced by a demyelinating strain
of mouse hepatitis virus. J. Virol. 82:8882-8886.
Qiu, Z., S. T. Hingley, G. Simmons, C. Yu, J. Das Sarma, P. Bates, and S. R. Weiss. 2006. Endosomal Proteolysis
by Cathepsins Is Necessary for Murine Coronavirus Mouse Hepatitis Virus Type 2 Spike-Mediated
Entry. J. Virol. 80:5768-5776.
Navas-Martin, S., S. Hingley, and S. R. Weiss. 2005. Murine coronavirus evolution in vivo: Functional compensation
of a detrimental amino acid substitution in the receptor binding domain of the spike
glycoprotein. J. Virol. 79:7629-7640.
Hingley, S. T., I. Leparc-Goffart, S. H. Seo, J. C. Tsai, and S. R. Weiss. 2002. The virulence of
mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage
and cell-to-cell fusion. J Neurovirol. 8:400-10.
Das Sarma, J., L. Fu, S.T. Hingley, E. Lavi. 2001. Mouse hepatitis virus type-2 infection in mice: an experimental model
system of acute meningitis and hepatitis. Exp. Mol. Pathol. 1:1-12.
Das Sarma, J., L. Fu, S.T. Hingley, M.M. Lai, E. Lavi. 2001. Sequence analysis of the S gene of recombinant MHV-2/A59
coronaviruses reveals three candidate mutations associated with demyelination and
hepatitis. J Neurovirol. 5:432-436.
Navas, S., S.H. Seo, M.M.Chua, J.D. Sarma, E. Lavi, S.T. Hingley and S.R Weiss. 2001. Murine coronavirus spike protein determines the ability of the
virus to replicate in the liver and cause hepatitis. J Virol. 75(5):2452-7.
Leparc-Goffart, I., S.T. Hingley, M-M. Chua, J. Phillips, E. Lavi and S.R. Weiss. 1998. Targeted recombination within
the spike gene of murine coronavirus MHV-A59: Q159L is a determinant of hepatotropism.
J. Virol. 72:9628-99636.
Hingley, S.T., I. Leparc-Goffart and S.R. Weiss. 1998. The spike protein of murine coronavirus
MHV-A59 is not cleaved in primary glial cells and primary hepatocytes. J. Virol. 72:1606-1609.
Denah M. Appelt, Christopher A. Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana
D. Zoga, Susan T. Hingley, Marcus G. Bell, Brian J. Balin. 2013. Changes in calcium-related gene expression
consistent with Alzheimer’s disease are initiated by infection of neuronal cells with
Chlamydia pneumoniae. Presented at the International Conference on Alzheimer’s Disease
Christopher A. Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana D. Zoga, Susan T. Hingley, Brian J. Balin, Denah M. Appelt, Marcus G. Bell. 2013. Chlamydia pneumoniae infection of neuronal cells induces changes in calcium-associated gene expression
consistent with Alzheimer’s disease. Presented at the Chlamydia Basic Science Research Meeting
Denah Appelt, Ian Kohler, Annette Slutter, Juliana Zoga, Susan T. Hingley, Brian Balin. 2012. Autophagy and apoptotic genes implicated in Alzheimer’s disease
are modulated following infection of neuronal cells with Chlamydia pneumoniae. Presented at the International Conference on Alzheimer’s Disease
Ian Kohler, Annette Slutter, Juliana Zoga, Susan T Hingley, Brain Balin, Denah Appelt. 2012. Genetic dysfunction related to Alzheimer’s disease
is found in neuronal cells after short-term and long-term Chlamydia pneumoniae infection. Presented at the Society for Neuroscience
Marcus Bell, Keith Williams, Juliana Zoga, Susan Hingley, Brian Balin, Denah Appelt. 2012. Alzheimer’s disease-like changes in calcium associated
gene expression and protein regulation following C. pneumoniae infection of neuronal cells and monocytes. Presented at the Society for Neuroscience
Morgan M. Devins, Fiora D. Zoga, Brian J.Balin, Denah M. Appelt, Susan T. Hingley. 2011 Infection of neuronal cells by Chlamydia pneumoniae and Herpes simplex virus type 1 alters expression of genes associated with Alzheimer’s
disease. Presented at the Society for Neuroscience
K. Cade, J. Romer, S. Hingley, 2011. Entry mechanisms of mouse hepatitis virus is more dependent on clathrin- than
caveolin-mediated pathways. Presented at the XIIth International Nidovirus Symposium
K. Kralik, D. Tabello, J. Das Sarma, S. Hingley. 2008. Entry of murine coronavirus MHV-A59 involves both clathrin-dependent and caveolin-dependent
pathways. Presented at the XIth International Nidovirus Symposium
K. Kralik, L. Triplett, J. Das Sarma, S. Hingley. 2007. The entry pathway used by murine coronavirus MHV-A59 is dependent on host
cell type. Presented at American Society for Virology 26th Annual Meeting
L. R. Triplett, K. S. Kralik, B. J. Balin, S. T. Hingley, D. M. Appelt. 2007. Analysis of Aβ 1-42 amyloid in neuronal cells infected with
Herpes Simplex Virus 1 and Chlamydophila (Chlamydia) pneumoniae. Presented at Federation for American Societies
for Experimental Biology Annual Meeting
2007-2008 – CCDA Pilot Research Project: Development of a real-time PCR assay for
the investigation of viral entry mechanisms
2008-2011 – Health Research Formula Fund: Entry Mechanisms of Mouse Hepatitis Virus,
an animal model for multiple sclerosis
2010-2011 – CCDA Pilot Research Project: Changes in expression of genes associated
with Alzheimer’s disease and β-amyloid processing due to infection of neuronal cells
by Chlamydia pneumoniae and/or herpes simplex virus type 1
- Alzheimer’s Disease
- Infectious Diseases/Agents
- Neurodegenerative Diseases