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Chen, Qian

Qian Chen, PhD

Qian Chen, PhD

Research Assistant Professor of Pathology, Microbiology, Immunology & Forensic Medicine
Department of Bio-Medical Sciences

Contact
Ph: 215-871-6153
FX: 215-871-6869
E-mail: qianch@pcom.edu

Education

PhD, MD, Xi’an Jiao Tong University, School of Medicine, P.R. China, 2001
MS, Xi’an Medical University, P.R. China, 1998
BS, Xi’an Medical University, P.R. China, 1995

Narrative

Dr. Chen is highly committed in using her medical knowledge and clinical/research experience to educate PCOM students. Since 2008, she has taught in pharmacology courses for the DO and Biomedical Sciences programs at PCOM, and since 2013 she has given biochemistry lectures to Biomedical Sciences students. Her teaching philosophy is student-centered and aims to provide students with accurate knowledge while nurturing them to develop critical thinking skills. She favors classroom dynamics that permit dialogue and foster student input, and she uses standardized practice questions in lecture to develop student problem-solving skills and to receive instantaneous feedback. Teaching also provides her the excellent opportunity to communicate with medical and graduate students, and to foster research work directed at meeting clinical needs. Additionally, she takes advantage of faculty strategic training lectures provided by PCOM to improve teaching skills by adapting to modern medical educational needs.

For the past decade, Dr. Chen's research has been conducted in topics related to the cardiovascular system. Currently, she is interested in finding the key mechanisms involved in various cardiovascular diseases, such as myocardial infarction, stroke and diabetes. Vascular endothelial dysfunction and inflammation are two critical events initiating the pathogenesis of these diseases, and in her lab multiple animal models and biochemical techniques are combined to evaluate blood vessel biochemical properties (e.g., blood nitric oxide and hydrogen peroxide) in real-time, organ blood perfusion, and inflammation (i.e., leukocyte-endothelial interactions). Her research will clarify the roles of endothelial nitric oxide synthase, NADPH oxidase, damaged mitochondria, and key enzyme regulations and signaling pathways, which will provide new treatment strategies for cardiovascular diseases.

Dr. CHen has served as thesis advisor or committee member for several Biomedical Sciences master's students, and she also provides research training to DO and graduate work-study students in the lab. Moreover, she has established research collaborations with internal and external senior researchers, such as Dr. Greene, Dr. Barsotti, Dr. Young, and Dr. Hatcher at PCOM, and Dr. Weis at Texas Tech University. The collaborations have led to journal paper publications, abstract/poster presentations at national scientific meetings, and grant submissions.

Selected Publications

Qian Chen, Elizabeth Eun Jung Kim, Katrina Elio, Christopher Zambrano, Samuel Krass, Jane Chun-wen Teng, Helen Kay, Kerry-Anne Perkins, Sailesh Pershad, Sloane McGraw, Jeffrey Emrich, Jovan S Adams and Lindon Young. The role of tetrahydorbiopterin and dihydrobiopterin in ischemia/reperfusion injury when given at reperfusion. Advances in Pharmacological Sciences, 2010: 963914, 2010.

Qian Chen, Brian Rueter, Samuel Krass, Christopher Zambrano, Shawn Thomas, Catherine Prince, Brandon Bell, Vincent Chai, Jeffery Emrich and Lindon Young. The potential clinical application of protein kinase C beta II peptide inhibitor and Gö 6983 in vascular endothelial dysfunction. Current Topics in Pharmacology, 14:11-24, 2010.

Qian Chen, Edward Iames, Daniel Torino, Kerry-Anne Perkins, Brian Rueter, Catherine Prince, and Lindon Howard Young. The effects of Gö 6983 and selective protein kinase C beta II peptide inhibitor on local hyperglycemia-induced leukocyte-endothelial interactions. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 282-283, 2011.

Maria A. Kern, Lindon H. Young, Edward S. Iames, and Qian Chen. The effects of protein kinase C epsilon peptide regulation on endothelial nitric oxide synthase (eNOS) uncoupling on leukocyte-endothelial interactions in rat mesenteric postcapillary venules. Proceedings of the 22nd American Peptide Symposium, Michal Lebl (Editor), American Peptide Society, 286-287, 2011.

Lindon H. Young, Qian Chen, Margaret T. Weis. Direct measurement of hydrogen peroxide (H2O2) or nitric oxide (NO) release: A powerful tool to assess real-time free radical production in biological models. American Journal of Biomedical Sciences 3(1):40-49, 2011.

Kerry-Anne A. Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S. Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Iyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng and Lindon H. Young. The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). Naunyn-Schmiedeberg’s Archives of Pharmacology 385(1):27-38, 2012.

Nina Blakeman, Qian Chen, Jasmine Tolson, Brian Rueter , Brian Diaz, Brendan Casey, Lindon H. Young, Margaret T. Weis. Triacsin C, a Fatty Acyl CoA Synthetase Inhibitor, Improves Cardiac Performance Following Global Ischemia. Am. J. Biomed. Sci., 4(3), 249-261, 2012.

Hung T. Pham, Robert Barsotti, Amber N. Koon, Brian Rueter, Lindon H. Young, and Qian Chen. The Role of NADPH Oxidase on L-NAME-induced Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 66-67, 2013.

Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.

Allan M. Prior, Man Zhang, Nina Blakeman, Palika Datta, Hung Pham, Qian Chen, Lindon H. Young, Margaret T. Weis, Duy H. Hua. Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury. Bioorganic & Medicinal Chemistry Letters 24 (4):1057-1061, 2014.

Selected Presentations

Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.

Alexandra C. Lopez, Qian Chen, Brittany L. Deiling, Edward S. Iames, Robert Barsotti, and Lindon H. Young. The Effects of Modulating Endothelial Nitric Oxide Synthase (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 58-59, 2013.

Galbreath T., Chen Q., Ondrasik R., Bertolet M., Barsotti R., Young L.. Effects of Mitochondrial-Targeted Antioxidants on Real-time Nitric Oxide and Hydrogen Peroxide Release in Hind Limb Ischemia and Reperfusion (I/R). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 46-47, 2013.

Issachar Devine, Qian Chen, Regina Ondrasik, William Chau, Katelyn Navitsky, On Say Lau, Christopher W. Parker, Kyle D. Bartol, Brendan Casey, Robert Barsotti, Lindon H. Young. Cardioprotective Effects of Cell Permeable NADPH oxidase inhibitors in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 42-43, 2013.

Matthew L. Bertolet, Michael Minni, Tyler Galbreath, Robert Barsotti, Lindon H. Young, and Qian Chen. Effects of Selective NADPH Oxidase Inhibitors on Real-Time Blood Nitric Oxideand Hydrogen Peroxide Release in Acute Hyperglycemia. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 34-35, 2013.

Hung T. Pham, Robert Barsotti, Amber N. Koon, Brian Rueter, Lindon H. Young, and Qian Chen. The Role of NADPH Oxidase on L-NAME-induced Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 66-67, 2013.

Regina Ondrasik, Qian Chen, Katelyn Navitsky, William Chau, Issachar Devine, On S. Lau,Tyler Galbreath, Robert Barsotti, and Lindon H. Young. Cardioprotective Effects of Mitochondrial-Targeted Antioxidants in Myocardial Ischemia/Reperfusion (I/R) Injury. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 64-65, 2013.

Acute hyperglycemia–induced oxidative stress and vascular endothelial dysfunction: roles of endothelial nitric oxide synthase and NADPH oxidase. M. Bertolet, M. Minni, T. Galbreath, M. Lepera, S. Patel, R. Selko, R. Barsotti, L. Young, and Q. Chen. Federation of American Societies for Experimental Biology, 28, 2014.

Volunteer & Leadership

Reviewer: Evidence-Based Complementary and Alternative Medicine

Grants

Center for Chronic Disorders of Aging (CCDA) at PCOM (07/01/2013-06/30/2014)
Title: The role of mitochondria in acute hyperglycemia: activation of vascular NADPH oxidase and eNOS uncoupling
Role on Project: PI

Pennsylvania State Tobacco Grant (grant #4100057680) 01/01/2012-12/31/2015
Title: “Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues”
Role on Project: Co-investigator

Research Keywords

  • Myocardial ischemia/reperfusion injury
  • Endothelial nitric oxide synthase
  • Hydrogen peroxide
  • Nitric oxide
  • Vascular endothelial dysfunction
  • Leukocyte-endothelial interactions
  • Hyperglycemia
  • Inflammation
  • Oxidative stress
Last Updated: 3/16/15