> navigate:  

Borghaei, Ruth

Ruth Borghaei, PhD

Ruth C. Borghaei, PhD

Professor of Biochemistry and Molecular Biology
Department of Bio-Medical Sciences

Ph: 215-871-6454
FX: 215-871-6865
E-mail: ruthb@pcom.edu


PhD, Microbiology and Immunology, Temple University School of Medicine, 1992
BS, (with highest distinction), Microbiology, University of Maine, 1987


Dr. Ruth Borghaei is a Professor in the Department of Biomedical Sciences. She is Director of the Molecular Basis of Medicine course in the Masters in Biomedical Sciences program and also teaches molecular biology and genetics to those students and to first-year DO students. Dr. Borghaei's research interest is in the homeostatic regulation of gene expression, particularly in response to inflammation.

Dr. Borghaei completed postdoctoral studies at the Institute for Cancer Research of the Fox Chase Cancer Center in Philadelphia. She is a member of the PCOM chapter of Sigma Xi, the American Society for Biochemistry and Molecular Biology and the American Society of Genetics.


Chambers, M, Kirkpatrick, G, Evans, M, Gorski, G, Foster, S and Borghaei, RC (2013) IL-4 inhibition of IL-1 induced Matrix Metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal Kinase (JNK) Exp. Cell Res. 319:1398. NIHMS ID 470770

Borghaei, R.C. and Chambers, M. (2009) Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines. Pathol. Lab. Med. Int. 1:7.

Borghaei, R.C., Gorski, G., Javadi, M. and Chambers, M. (2009) NF-ƙB and ZBP-89 regulate MMP-3 expression via a polymorphic site. Biochem. Biophys. Res. Comm. 382(2009):269. NIHMSID 171948

Stewart, DK, Javadi, M., Chambers, M, Gunsolly, C, Gorski, G and Borghaei, RC (2007) Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARγ activation in human gingival fibroblasts. BMC Molecular Biology 8:12 PMC1810308

Borghaei, R.C., Rawlings, P.L. Jr., Javadi, M. and Woloshin, J. (2004) NF-B binds to a polymorphic repressor element in the MMP-3 promoter. Biochem. Biophys. Res. Comm. 316:182-188. PMC1595538

Jenkins, K, Javadi, M., and Borghaei, R.C. (2004) Interleukin-4 suppresses interleukin-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts. J. Periodontol. 75:267-275. PMC1595536

Daghigh, F., Borghaei, R.C., Thornton, R.D. and Bee. J.H. (2001) Human gingival fibroblasts produce nitric oxide in response to pro-inflammatory cytokines. J. Periodontol. 73:392-400.

Thornton, R.D., Lane, P., Borghaei, R.C., Pease, E.A., Caro, J., and Mochan, E. (2000) Interleukin-1 induces hypoxia inducible factor-1 in human gingival and synovial fibroblasts. Biochem. J. 350:307-312.

Gorski, G.K., Paul, M., SooHoo, H., Borghaei, R.C., Mochan, E., Thornton, R. and Pease, E. (1999) Identification of IL-1 regulated genes in human synovial and gingival fibroblasts by differential display. Inflamm Res. 48:S122-123

Borghaei, R.C., Sullivan, C. and Mochan, E. (1999) Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3). J. Biol. Chem. 274:2126-2131. PMC1595537

Borghaei, R.C., Sinai, R.S., Mochan, E. and Pease, E.A. (1998) Mitogen-inducible nuclear orphan receptor (MINOR) is induced by interleukin 1 in human synovial and gingival fibroblasts. Biochem. Biophys. Res. Comm., 251:334-338.

Fowler, M.J. Jr., Neff, M.S., Borghaei, R.C., Pease, E.A., Mochan, E. and Thornton, R.D. (1998) Induction of bone morphogenetic protien-1 by interleukin 1 in human fibroblasts. Biochem. Biophys. Res. Comm., 248:450-453.

Borghaei, R.C., Rawlings P.L., Jr. and Mochan, E. (1998) Interleukin 4 suppression of interleukin 1 induced transcription of collagenase (MMP-1) and stromelysin (MMP-3) in human synovial fibroblasts. Arthritis and Rheum., 41:1398-1406. PMC1602062

Ni, X., Borghaei, H., Borghaei, R.C., Thornton, R.D., Pease, E. and Mochan, E. (1997) DGLA discoordinately supresses IL-1 induced metalloproteinase mRNA levels in human synovial fibroblasts. Inflamm. Res. 46: S124-126.

Borghaei, H, Borghaei, R.C., Ni, X., Pease, E., Thornton, R. and Mochan, E. (1997) Inhibition of IL-1 induced Collagenase expression by dihomo-Ɣ-linolenic acid (DGLA) may be mediated by inhibition of NFƙB binding. Inflamm Res. 46:S177-178.

Soprano, D.R., Chen, L.X., Wu, S., Donigan, A.M., Borghaei, R.C. and Soprano, K.J. (1996) Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition. Oncogene 12:577-584

Carter, R., Yumet, G., Pena, A. Soprano, D.R. and Soprano, K.J. (1994) Transcriptional regulation of c-jun expression during late G1/S in normal human cells is lost in human tumor cells. Oncogene 9:2675-2682.

Volunteer & Leadership

Participated in ASBMB-UAN Leaders Biochemistry Concept Inventory Workshop, by invitation, 2012

Peer reviewer of manuscripts: Archives Oral Biology, GENE, International Journal of Cancer, Journal of Cellular Physiology, Journal of Periodontology, Life Sciences

Peer reviewer of grants: Internal science review advisor, PCOM; Health Research Board of Ireland; Clinical Research Training Fellowships; NIH Special Emphasis Panel, ZRG1 GGG-F (90), November 2007; NIH Special Emphasis Panel, ZRG1 MOSS-E(02)M, March 2007

Writer of questions for NBOME Complex I – 2003 to 2008

Previous Grant Funding

7/1/10 to 6/30/11 CCDA, PCOM Principal Investigator
Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells.

9/1/04 to 8/31/10 NIH R15 DE16277 Principal Investigator
Transcriptional regulation of matrix metalloproteinase 3
[Research Supplement to Promote Diversity in Health-related Research, 2005-2006]

8/1/97 to 5/31/03 NIH R29 DE12096-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
[Supplement for Underrepresented Minorities, 2000-2001]

9/15/95 to 7/14/97 NIH RO3 DE11577-01 Principal Investigator
IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts

Research Keywords

  • Inflammation
  • Gene Regulation
  • Molecular Biology
  • Matrix Metalloproteinases
  • Periodontitis
Last Updated: 2/24/15