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Bell, Marcus

Marcus Bell, PhD Marcus Bell, PhD

Director, Graduate Program in Biomedical Sciences
Professor of Neuroscience, Physiology & Pharmacology
Department of Bio-Medical Sciences

 

Contact
Ph: 215-871-6834
FX: 215-871-6889
E-mail: marcusbe@pcom.edu

Education

Postdoctoral Fellowship, Thomas Jefferson University
PhD, Biophysics, University of Pennsylvania
BS, Electrical Engineering, University of Pennsylvania

Narrative

Dr. Bell educates on topics of muscle physiology and neuroscience within several courses in the Doctor of Osteopathic Medicine program and the Graduate Program in Biomedical Sciences. In these courses his goal is to break down difficult physical and biochemical concepts into paradigms that can be comprehended and remembered intuitively for future understanding the function of the body its response to disease and to osteopathic and pharmacological interventions. To help foster comprehensive educational approaches through deliberate, innovative curriculum design and delivery, as well as through supporting our students at all levels by means of appropriate resources, Dr. Bell serves on numerous committees involving student academic matters from admission through graduation. Dr. Bell also directs the Journal Club course for the Biomedical Sciences Research Concentration.

Dr. Bell's basic science research has been concentrated in two areas. 1) In his work with other researchers on the regulatory systems of cardiac and skeletal muscle, he hopes to elucidate the mechanism by which changes in intracellular calcium are translated into the varying rate and strength of the muscular contraction. The technique of time-resolved polarized fluorescence is used to measure motions of the regulatory proteins as calcium binds to activate the system. The rate and extent of regulatory protein movement is compared to the rate and extent of force generation. By combining results from fluorescent probes attached to several sites in the system, a broader understanding of the mechanism may be achieved. 2) In his collaborations with researchers focused on Alzheimer's Disease, Dr. Bell investigates the root causes of neuropathological cascades characteristic of the disease. Of particular interest are the roles of infections agents, such as C. pneumoniae, in evading the immune response even as they induce host cells to secrete compounds, such as abnormal amyloid beta protein, that ultimately lead to the death of neighboring cells in the brain.

Dr. Bell also collaborates in research focused on medical education, and is a member of the International Association of Medical Science Educators (IAMSE).

Selected Publications

Bell, M.G., Dale, R.E., Van der Heide, U.A. and Goldman, Y.E. 2002. Polarized fluorescence depletion reports orientation distribution and rotational dynamics of muscle cross-bridges. Biophys. J. 83(2):1050-1073.

Martin, H., Bell, M.G., Ellis-Davies, G.C. and Barsotti R.J. 2004. Activation kinetics of skinned cardiac muscle by laser photolysis of nitrophenyl-EGTA. Biophys. J. 86(2):978-990.

Bell, M.G., Lankford, E.B., Gonye, G.E., Ellis-Davies, G.C., Martyn, D.A., Regnier, M. and R.J. Barsotti. 2006. Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin c in skinned guinea pig trabeculae. Biophys J. 90(2):531-543.

Appelt, D.M., Roupas, M.R., Way, D.S., Bell, M.G., Albert, E.V., Hammond, C.J. Balin, B.J. 2008. Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae. BMC Neuroscience 2008, 9:13. (Earned journal’s “highly accessed” rating.)

Selected Presentations

Bell, M.G., Barkalow, K., Hamasaki, T. and Satir, P. 1991. Photolysis of caged ATP initiates dynein-mediated translocation of microtubules. Biophys. J., 59:567a.

Bell, M.G., Matta, J.J., Thomas, D.D. and Goldman, Y.E. 1993. Changes in cross-bridge kinetics induced by SH-1 modification in rabbit psoas fibers. Biophys. J., 64:252a.

Bell, M.G., Matta, J.J., Thomas, D.D. and Goldman, Y.E. 1995. Changes in cross-bridge kinetics induced by SH-1 modification in rabbit psoas fibers. Biophys. J., 68:360s.

Bell, M.G., Dale, R.E., Van der Heide, U.A. and Goldman, Y.E. 2000. Polarized fluorescence depletion reports orientation distribution and rotational dynamics of muscle cross-bridges. Biophys. J., 78(4):326s.

Martin, H., Hager, R., Bell, M.G. and Barsotti, R.J. 2001. Temperature sensitivity of phosphate-induced tension transients in skinned cardiac muscle. Biophys. J., 80:586a.

Bell, M.G., Martin, H., Ellis-Davies, G.C.R., Martyn, D.A., Regnier, M. and Barsotti, R.J. 2002. Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C. Biophys. J., 82:170a.

Martin, H., Bell, M.G., Hager, R. and Barsotti, R.J. 2003. Effects of Ca2+ and temperature on the force-generating transition in cardiac muscle studied by photolysis of caged-phosphate. Biophys. J. 84:3488.

Way, D.S., Albert, E.V., Hammond, C.J., Bell, M.G, Balin, B.J. and Appelt, D.M: 2006. Caspase activity is inhibited in neuronal cells infected with Chlamydia pneumoniae: Implications for apoptosis in Alzheimer’s Disease. 10th ICAD conference, Madrid, Spain.

Elizabeth K. Ruszak, Keren C. McCarthy, Marcus G. Bell, Brian J. Balin, Denah M. Appelt, 2008. Chlamydophila (Chlamydia) pneumoniae promotes AB 1-42 amyloid processing in Neuronal Cells: A Pathogenic Trigger for Alzheimer’s Disease. AOA Convention.

Denah M. Appelt, Elizabeth K. Ruszak, Marcus G. Bell, Brian J. Balin. 2008. Increased Aβ 1-42 amyloid processing into oligomers in astrocytes and neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae. Society for Neuroscience meeting.

Hoyt, J.A., Kuchera, M.L., Daghigh, F., Bell, M., Schoenfeldt, B., Overberger, R., Bailey, J. 2008. Comparing Changes in Serum Nitric Oxide Levels and Heart Rate After Periodic Acceleration Therapy (PAT) Using an AT101TM Table to Changes Measured After Active Exercise. AOA Annual Convention.

Hoyt, J.A., Kuchera, M.L., Daghigh, F., Bell, M., Schoenfeldt., B., Overberger, R., Bailey, J. 2008. Comparing Changes in Serum Nitric Oxide Levels and Heart Rate After Osteopathic Manipulative Treatment (OMT) Using Dalrymple Pedal Pump to Changes Measured After Active Exercise. AOA Annual Convention.

Keith Williams, Juliana Zoga, Susan Hingley, Brian Balin, Denah Appelt, Marcus Bell. 2012. Infection with Chlamydia Pneumoniae alters calcium-associated gene regulation and processes in neuronal cells and monocytes: Implications for Alzheimer’s Disease. 21st Annual Philadelphia Infection and Immunity Forum.

Marcus Bell, Keith Williams, Juliana Zoga, Susan Hingley, Brian Balin, Denah Appelt. 2012. Alzheimer’s disease-like changes in calcium associated gene expression and protein regulation following C. pneumoniae infection of neuronal cells and monocytes. Society for Neuroscience meeting.

Victoria Lawn, Matthew Jaffa, Catherine Babbitt-Cook, Burton Mark, Jane Dumsha, Marcus Bell, Denah Appelt. 2012. Reducing the Stigma of Mental Illness Among Medical Students. AOA Annual Convention.

Christopher A. Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana D. Zoga, Susan T. Hingley, Brian J. Balin, Denah M. Appelt, Marcus G. Bell Chlamydia pneumoniae infection of neuronal cells induces changes in calcium-associated gene expression consistent with Alzheimer’s disease, CBRS meeting, 2013.

Denah M. Appelt, Christopher A. Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana D. Zoga, Susan T. Hingley, Marcus G. Bell, Brian J. Balin, Changes in calcium-related gene expression consistent with Alzheimer’s disease are initiated by infection of neuronal cells with Chlamydia pneumoniae, AAIC 2013

James M. Brandt, Ahmad B. Cader, Lauren Semler, Christine J. Hammond, Marcus G. Bell, Jenayle L. Smith, Nicol E. Joseph, Morgan Devins, Marisol Velez, Katherine E. Galluzzi, Balin J. Balin, Denah M. Appelt: Electron microscopy studies elucidate morphological forms of Chlamydia pneumoniae in blood samples from patients diagnosed with mild cognitive impairment (MCI) and Alzheimer’s disease (AD); FASEB 2014.

Brian Balin, James Brandt, Christine Hammond, Ahmad Cader, Lauren Semler, Nicol Joseph, Marcus Bell, Merisol Velez, Morgan Devins, Katherine Galluzzi, Denah Appelt: Biomarkers of infection with Chlamydia pneumoniae in the geriatric population: a potential diagnostic screen for cognitive decline? AAIC 2014.

Volunteer & Leadership

Learning Resources Committee, 2014-present

Student Academic Policy & Progress Committee, 2013-present; chair, 2014-present.

DO Student Progress Evaluation Committee, 2013-present.

Biomedical Sciences Student Progress Evaluation Committee, 2012-present.

Program Director, Graduate Program in Biomedical Sciences, 2012-present.

DO Admissions Committee, 2013-present.

Graduate Programs Admissions Committee, 2011-present.

DO Curriculum Committee (non-voting), 2011-present.

Graduate Programs Curriculum Committee, 2011-present.

Director, Biomedical MS Research Concentration, 2009-present.

Biological Imaging Facility, consultant for instrumentation and software, 2001-present.

The President’s Diversity Council, 2013-2014.

Middle States Accreditation, Educational Offerings Self-Study Committee, 2012-2014.

AOA-COCA Accreditation, Student Self-Study Committee, co-chair, 2011-2012.

Institutional Review Board, 2001-2003.

Grants

Center for Chronic Disorders of Aging (PCOM), 2012-2013. Dectection of Chlamydia pneumoniae in blood samples: A diagnostic screen for Alzheimer’s disease. Role: Co-PI.

Center for Chronic Disorders of Aging (PCOM), 2012-2013. Infection with Chlamydia Pneumoniae alters calcium-associated gene regulation and processes in neuronal cells and monocytes: Implications for Alzheimer’s disease. Role: PI.

NIH 5R01HL086838-04, 2008-2012. Determinants of Cardiac Thin Filament Regulation. Co-PI with Robert J. Barsotti, PCOM.

American Heart Grant-In-Aid, 2002-2004, Mechanism of Thin-Filament Based Control of Cardiac Muscle Contraction. Co-authored with Robert J. Barsotti, Thomas Jefferson University.

HHS SBIR Phase II, 1996-1998. Sucking Device for Feeding Of Low-Birthweight Infants. Co-authored with BioFlo, Inc., and KDL Medical Technologies, Inc., Philadelphia.

Research Keywords

  • Muscle
  • Cardiac Function
  • Alzheimer's Disease
  • Infectious Diseases/Agents
  • Medical Education
Last Updated: 3/19/15