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  Academic Programs


Brian Balin, Ph.D. Publications

Peer-Reviewed Publications
Appelt, D.M., Roupas, M., Hammond, C.J., Little, C.S., and Balin, B.J.: Apoptotic effects of
    Chlamydophila pneumoniae following infection of neuronal cells. (Submitted BMC
), 2007.
Way, D., Albert, E., Hammond, C., Bell, M., Balin, B., Appelt, D. Caspase activity is inhibited
    in neuronal cells infected with Chlamydia pneumoniae: implications for apoptosis in
    Alzheimer's disease. In Alzheimer's disease: New Advances, Medimond Internatl
, 295-99, 2006.
Hammond, C., Little, C.S., Longo, N., Procacci, C., Appelt, D., Balin, B. Antibiotic alters
    inflammation in the mouse brain during persistent Chlamydia pneumoniae infection. In
    Alzheimer's disease: New Advances, Medimond Internatl Proceedings
    537-540, 2006.
Balin, B., Hammond, C., Taylor, A., Tuitt, K., Abraham, J., Appelt, D. Immunodetection of
    Chlamydophila (Chlamydia) pneumoniae in the Alzheimer brain. In Alzheimer's
    disease: New Advances, Medimond Internatl Proceedings
, 301-5, 2006.
Narins, S.C., Park, E.H., Ramakrishnan, R., Garcia, F.U., Diven, J.N., Balin, B.J., Hammond,
    C.J., Sodam, B.R., Smith, P.R., Abedin, M.Z. Functional characterization of Na(+)/(H+)
    exchangers in primary cultures of prairie dog gallbladder. J. Membr. Biol. 197:
    123-134, 2004.
Abrams, J.T., Balin, B.J., and Vonderheid, E.C.: Association between Sezary T Cell
    Activating Factor, Chlamydia pneumoniae, and Cutaneous T Cell Lymphoma. New York
    Acad Sci 941:
69-85, 2001.
Katsetos, C.D., Valle, L.D., Geddes, J.F., Assimakopoulou, M., Legido, A., Boyd, J.C., Balin,
, Parikh, N.A., Maraziotis, T., de Chadarevian, J-P., Varakis, J.N., Matsas, R.,
    Frankfurter, A., Herman, M.M., and Khalili, K.: Aberrant localization of the neuronal class
    III beta-tubulin in astrocytomas. Arch Pathol Lab Med 125(5):613-624, 2001.
Abrams, J.T., Vonderheid, E.C., Kolby, S.J., Appelt, D.M., Arking, E.J., and Balin, B.J.:
    Sezary T Cell Activating Factor is a Chlamydia pneumoniae associated protein. Clin.
    Diag. Lab. Immuno. 6 (6):
895-905, 1999.
Gerard H.C., Wang G.F., Balin, B.J., Schumacher H.R., and Hudson A.P.: Frequency of
    apolipoprotein E (APOE) allele types in patients with Chlamydia-associated arthritis and
    other arthritides. Microbial Pathogenesis 26:35-43, 1999.
Reed, L.A., Schmidt, M.L., Wszolek, Z.K., Balin, B.J., Sootorniyomkij, V., Lee, V.M.-Y.,
    Trojanowski, J.Q., and Schelper, R.L.: The Neuropathology of Chromosome 17-linked
    Autosomal Dominant Parkinsonism-Dementia (Pallido-ponto-nigral degeneration). J.
    Neuropath. & Exper. Neurol. 57:
588-601, 1998.                                          
Lieberman, A.P., Trojanowski, J.Q., Lee, V.M.-Y., Balin, B.J., Ding, X.-S., and Grossman, M.:
    Cognitive, Neuroimaging, and Pathological studies of Pick's Disease. Ann. Neurol. 43:
    259-265, 1998.
Katsetos, C.D., Herman, M.M., Balin, B.J., Arking, E.J., Vinores, S.A., Karkavelas, G. and
    Frankfurter, A.: Divergent neuronal and glial differentiation of the PC12 rat pheo-
    chromocytoma cell line maintained in a gelfoam matrix system: An immunoperoxidase
    and immunoblot study with antibodies to neuronal cytoskeletal proteins, synaptophysin,
    GFAP and S100 protein. Anat. Record 250:351-365, 1998.
Appelt, D.M. and Balin, B.J.: The association of tissue transglutaminase with human
    recombinant tau results in the formation of insoluble filamentous structures. Brain
    Res. 745:
21-31, 1997.
Mawal-Dewan, M., Schmidt, M.L., Balin, B.J., Perl D.P., Lee, M.-Y.L. and Trojanowski, J.Q.:
    Identification of phosphorylated sites in PHF-tau from patients with Guam Amyotrophic
    lateral sclerosis/Parkinsonism-Dementia Complex. J. Neuropathol. Exper. Neurol. 55:
    1051-1059, 1996.
Appelt, D.M., Kopen, G.C., Boyne, L.J. and Balin, B.J.: Localization of transglutaminase in
    hippocampal neurons: Implications for Alzheimer Disease. J. Histochem. Cytochem.
1421-1427, 1996.
Balin, B.J. and Miller, M. E.: Assembly of the 66kDa neurofilament protein in vitro and its
    association with NF-L, NF-M and NF-H purified from bovine spinal cord. J. Neurosci. Res.
79-88, 1995.
Appelt, D.M. and Balin, B.J.: Analysis of paired helical filaments found in Alzheimer's Disease
    using freeze-drying/rotary shadowing. J. Struct. Biol. 111: 85-95,1993.
Mulligan, L., Balin, B.J., Lee, V.M.-Y., Ip, W.: Antibody labeling of bovine neurofilaments:
    Implications on the structure of neurofilament sidearms. J. Struct. Biol. 106:145-160,
Balin, B.J. and Lee, V.M.-Y.: Individual neurofilament subunits reassembled in vitro exhibit
    unique biochemical, morphological and immunological properties. Brain Res. 556:
    196-208, 1991.
Balin, B.J., Clark, E.A., Trojanowski, J.Q. and Lee, V.M-Y.: Neurofilament reassembly In
Biochemical, Morphological and Immunoelectron microscopic studies employing
    monoclonal antibodies to defined epitopes. Brain Res. 556: 181-195, 1991.
Lee, V.M.-Y., Balin, B.J., Otvos Jr., L., Hollosi, M. and Trojanowski, J.Q.: A68: A major
    subunit of paired helical filaments and derivatized forms of normal Tau. Science 251:
    675-678, 1991.
Broadwell, R.D., Balin, B.J., Salcman, M.: Transcytotic pathway for blood-borne protein
    through the blood-brain barrier. Proc. Natl. Acad. Sci. USA 85: 632-636, 1988.
Balin, B.J. and Broadwell, R.D.: Transcytosis of protein through the mammalian cerebral
    epithelium and endothelium. I. Choroid plexus and the blood-cerebrospinal fluid barrier.
    J. Neurocytol. 17: 1-18, 1988.
Broadwell, R.D., Charlton, H.M., Balin, B.J. and Salcman, M: Angioarchitecture of the CNS,
    Pituitary Gland, and Intracerebral Grafts Revealed with Peroxidase Cytochemistry. J.
    Comp Neurol. 260:
47-62, 1987.
Broadwell, R.D., Balin, B.J. and Salcman, M.: Polarity of the blood-brain barrier to the
    endocytosis of exogenous protein. Wiss. K.Marx-U. Math.-Naturwis. 36:171-175,
Balin, B.J., Broadwell, R.D. and Salcman,M.: Tubular profiles do not form transendo-thelial
    channels through the blood-brain barrier. J. Neurocytol. 16: 721-735, 1987.
Balin, B.J. and Broadwell, R.D.: Lectin-labeled membrane is transferred to the Golgi
    Complex in mouse pituitary cells in vivo. J. Histochem. Cytochem. 35: 489-498,
Balin, B.J., Broadwell, R.D., Salcman, M. and El-Kalliny, M.: Avenues for entry of
    peripherally administered protein to the central nervous system in mouse, rat and
    squirrel monkey. J. Comp. Neurol. 251(2): 260-280, 1986.
Broadwell, R.D. and Balin, B.J.: Endocytic and exocytic pathways of the neuronal secretory
    process and trans-synaptic transfer of wheat germ agglutinin-horseradish peroxidase
    in vivo. J. Comp. Neurol. 242: 632-650, 1985.
Broadwell, R.D., Cataldo, A.M. and Balin, B.J.: Further studies of the secretory process in
    hypothalamo-neurohypophysial neurons. An analysis using immunochemistry, wheat
    germ agglutinin-peroxidase and native peroxidase. J. Comp. Neurol. 228:155-167,
Broadwell, R.D., Balin, B.J., Salcman, M. and Kaplan, R.S.: A brain-blood barrier? Yes and
    no. Proc. Natl. Acad. Sci. USA 80: 7352-7356, 1983.
Publications: Chapters and Reviews
Broadwell, R.D., Balin, B.J. and Cataldo, A.M.: Fine structure and cytochemistry of the
    median eminence. In: Gross, P.M., (ed.): Circumventricular Organs and Body
Boca Raton, Fla.: CRC Press, 1987.
Balin, B.J., Loewy, A.R. and Appelt, D.M.: Analysis of Transglutaminase-catalyzed Isopeptide
    Bonds in Paired Helical Filaments and Neurofibrillary Tangles From Alzheimer's Disease.
    In: Amyloid and other protein deposition: methods and models. (Methods in
    Enzymology 309
:172-186, 1999; Academic Press, Orlando, Fl; edited by Ronald
    Wetzel, Ph.D.).
Balin, B.J. and Binstock, R.H.: Perspectives on Changes in the Human Brain as a Function of
    Aging. The Gerontologist 39: 745-749, 1999; Comparative book review.
Balin, B.J. and Appelt, D.M.: Transglutaminase-catalyzed Formation of Alzheimer-like
    Insoluble Complexes From Recombinant Tau. In:Alzheimer's Disease: Methods and
    Protocols. (In Methods in Molecular Medicine, pp 395-403, The Humana Press, Inc.,
    Totowa, NJ; edited by Dr. Nigel M. Hooper, 2000).
Hudson, A.P., Gerard, H.C., Whittum-Hudson, J.A., Appelt, D.M., Balin, B.J.: Chlamydia
, APOE genotype, and Alzheimer's Disease. In: Chlamydia pneumoniae
    and Chronic Diseases
, pp 121-136, 2000; Springer-Verlag, Berlin, Germany; edited by
    Johanna L'Age-Stehr).
Balin, B.J., Appelt, D.M.: The Role of Infection in Alzheimer's Disease. Journal of the
    American Osteopathic Association 101 (12 Suppl PT 1):
S1-S6, 2001.
Balin, B.J., Appelt, D.M., Whittum-Hudson, J.A., Hudson, A.P.: Infectious Agents and
    Alzheimer's Disease. Recent Research Developments in Molecular and Cellular
    Biochemistry 1:
187-202, 2003.
Balin, B.J., Hammond, C.J., Little, C.S, MacIntyre, A., Appelt, D.M.: Chlamydia pneumoniae
    in the Pathogenesis of Alzheimer's disease. In:Chlamydia pneumoniae Infection and
Kluwer Academic/Plenum Publishers, New York, New York; Edited by Drs. M.
    Bendinelli, Y. Yamamoto, and H. Friedman, 2004, pp. 211-226.
Young, L.H., Balin, B.J., and Weis, M.T.: Go 6983: A fast acting protein kinase C inhibitor
    that attenuates myocardial ischemia/reperfusion injury. Cardiovascular Drug Reviews
255-272, 2005.
Balin, B.J., Appelt, D.M., Little, C.S., Hammond, C.J., Whittum-Hudson, J.A., Hudson, A.P.:
    Chlamydophila (Chlamydia) pneumoniae in Alzheimer's disease. In: Microbial
    Infections of the Neurologic System.
Springer Publishers; Edited by Andreas Seyfang,
    H. Friedman, and M. Bendinelli, (in press), 2007.