Dr. Xu received her M.D. from Beijing University School of Medicine and her Ph.D.
in Neuroscience from The National University of Singapore. She had postdoctoral training
at Georgia State University (2002-2004) and Emory University School of Medicine (2005-2010).
She was awarded NRSA fellowship by National Institute of Neurological Disorders and
Stroke in 2006. She also received merit award from Emory University and research funding
from private agencies. Dr. Xu taught gross anatomy at Emory University School of Medicine
for 2 years before she joined Department of Bio-Medical Sciences, PCOM as Assistant
Professor in September 2010.
The ultimate goal of my laboratory is to improve functional recovery from axon degeneration
in neurodegenerative diseases and following the brain, spinal cord and peripheral
nerve injuries. We are currently studying the roles of localized mRNAs and their binding
proteins in axon regeneration. We utilize multidisciplinary approaches, including
primary neuronal culture, rodent microsurgery, viral vectors, fluorescently tagged
proteins, molecular and biochemical methods. Understanding mechanisms underlying axon
regeneration will help to develop therapeutic approaches for functional recovery.
Tadesse, T.T. †, Cheng Q. †, Xu, M. †, Young, L.J., Baro, D.J., and Pallas, S.L. 2013. Regulation of Ephrin-A gradients
in compressed retinocollicular maps. Dev. Neurobiol. 73: 274-296. † Equal Contribution.
Wilhelm, J.C., Xu, M., Cucoranu, D., Chmielewski S., Holmes T., Lau K., Bassell, G.J., English, A. 2012.
Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by
exercise to facilitate nerve regeneration. J. Neurosci. 32: 5002-5009.
Donnelly, C.J.†, Willis, D.E.†, Xu, M. †, Tep, C., Kendall, M., Jang, C., Yoo, S., Schanen, N.C., Kirn-Safran, C.B. 2, van
Minnen, J., English, A, Yoon, S.O., Bassell, G.J., and Twiss, J.L. 2011. Limited availability
of ZBP1 restricts axonal mRNA localization and nerve regeneration capability. EMBO J. 30, 4665-4677. † Equal Contribution.
Willis, D.E.†, Xu, M. †, Donnelly, C.J.†, Tep, C., Kendall, M., Erenstheyn, M., English, A, Schanen, N.C.,
Kirn-Safran, C.B. 2, Yoon, S.O., Bassell, G.J., and Twiss, J.L. 2011. Axonal localization
of transgene mRNA in mature PNS and CNS neurons. J. Neurosci. 31:14481-14487. † Equal Contribution.
Sasaki, Y., Welshhans, K., Wen, Z., Yao, J., Xu, M., Zheng J.Q., and Bassell, G.J. 2010. Phosphorylation of zipcode binding protein is
required for BDNF signaling of local β-actin synthesis and growth cone turning. J. Neurosci. 30: 9349-9358.
Muddashetty, R. †, Kelic S. †, Gross C., Xu, M., and Bassell, G.J. 2007. Dysregulated mGluR-dependent translation of AMPA receptor
and PSD-95 mRNAs in a mouse model of Fragile X syndrome. J. Neurosci. 27, 5338-5348. † Equal Contribution
Carson, J.P., Ju, T., Lu, H.C., Thaller, C., Xu, M., Pallas, S.L., Crair, M.C., Warren, J., Chiu, W., and Eichele, G. 2005. A digital
atlas to characterize the mouse brain transcriptome. PLoS Comput. Biol. 1, e41 (Front cover feature).
Xu, M., Ng, Y.K., Yip, G.W., and Gan, L. 2005. Distinct roles of oxidative stress and anti-oxidants
in nucleus dorsalis and red nucleus following spinal cord hemisection. Brain Res. 1055, 137-142.
Xu, M., Ng, Y.K., and Wong, P. 2002. Localization of neuronal nitric oxide synthase in the
central nervous system. Method Enzymol. 359, 424-432.
Xu, M., Ng, Y.K., and Leong, S.K. 2000. Distinct subcellular localization and mRNA expression
of neuronal nitric oxide synthase in the nucleus dorsalis and red nucleus and their
correlation with inducible transcription factors after spinal cord hemisection. Nitric Oxide: Biology and Chemistry4, 483-495 (Front cover feature).
Xu, M., Ng, Y.K., and Leong, S.K. 2000. Neuroprotective and neurodestructive functions of
nitric oxide after spinal cord hemisection. Exp. Neurol. 161, 472-480.
Xu, M., Ng, Y.K., and Leong, S.K. 1998. Induction of microglial reaction and expression
of nitric oxide synthase in the nucleus dorsalis and red nucleus following lower thoracic
spinal cord hemisection. Brain Res. 808, 23-30.